Interleukin Related
IL
Interleukins are a group of cytokines (secreted proteins and signaling molecules) that were first seen to be expressed by white blood cells (leukocytes). The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T and B lymphocytes, and hematopoietic cells. Interleukin receptors on astrocytes in the hippocampus are also known to be involved in the development of spatial memories in mice.
Interleukin Related Isoform Specific Products
-
Interleukin Related
(949)
View all products
-
IL-1
(483)
View all products
-
IL-2
(116)
View all products
-
IL-3
(8)
View all products
-
IL-4
(89)
View all products
-
IL-5
(34)
View all products
-
IL-6
(506)
View all products
-
IL-8
(103)
View all products
-
IL-10
(95)
View all products
-
IL-12
(39)
View all products
-
IL-13
(56)
View all products
-
IL-15
(10)
View all products
-
IL-17
(107)
View all products
-
IL-23
(38)
View all products
-
IL-7
(15)
View all products
-
IL-33
(5)
View all products
-
IL-22
(11)
View all products
-
IL-18
(23)
View all products
All Product Categories
-
Interleukin Related Inhibitors
(1594)
View all products
-
Interleukin Related Agonists
(15)
View all products
-
Interleukin Related Antagonists
(33)
View all products
-
Interleukin Related Activators
(166)
View all products
-
Interleukin Related Modulators
(101)
View all products
-
Interleukin Related Chemicals
(2)
View all products
-
Interleukin Related Inducers
(62)
View all products
-
Interleukin Related Degraders
(2)
View all products
-
Interleukin Related Controls
(2)
View all products
-
Interleukin Related Ligands
(10)
View all products
-
IL-4 Proteins
(26)
View all products
-
IL-12 Proteins
(39)
View all products
-
IL-17 Proteins
(71)
View all products
-
IL-8/CXCL8 Proteins
(16)
View all products
-
Multi-CSF/IL-3 Proteins
(18)
View all products
-
IL-1 Proteins
(43)
View all products
-
IL-2 Proteins
(22)
View all products
-
IL-5 Proteins
(20)
View all products
-
IL-6 Proteins
(24)
View all products
-
IL-10 Proteins
(16)
View all products
-
IL-13 Proteins
(19)
View all products
-
IL-15 Proteins
(18)
View all products
-
IL-23 Proteins
(22)
View all products
-
Interleukin Related Related Products (2249)
Related Products (2249)
-
Recombinant Proteins (352)
-
Antibodies (36)
-
Interleukin Related Isoform Comparison
-
HPK1-IN-58
0 ImagesCat. No.: HY-172875CAS No.: 3093724-62-7HPK1-IN-58 (Compound 26) is an inhibitor of HPK1 (IC50: 2.6 nM) and SLP76 (IC50: 20 nM). HPK1-IN-58 enhances IL-2 secretion and reverses PGE2-induced immunosuppression. HPK1-IN-58 can be used in anti-tumor immunity research.
-
H-Hyp-Leu-OH
0 ImagesCat. No.: HY-P12327CAS No.: 637030-43-4H-Hyp-Leu-OH is a linear dipeptide of hydroxyproline-leucine with anti-inflammatory and antioxidant activities. H-Hyp-Leu-OH inhibits NO, IL-1β, IL-6, and TNF-α in macrophages, and upregulates IL-10. H-Hyp-Leu-OH extends lifespan, improves exercise capacity, reduces ROS and MDA, and increases SOD, CAT, and GSH-Px. H-Hyp-Leu-OH can be used for epithelial ovarian cancer and antioxidant-related research.
-
R-03201195
0 ImagesCat. No.: HY-18794CAS No.: 249936-55-8R-03201195 is an efficient and selective p38 MAP kinase inhibitor with an IC50 for p38α of 0.7 nM. R-03201195 has inhibitory activity against TNF-α in THP-1 cells and against IL-1β in human whole blood, with IC50 values of 0.25 and 0.57 nM respectively. R-03201195 can be used for inflammatory diseases such as rheumatoid arthritis.
-
Interleukin II (60-70)
0 ImagesCat. No.: HY-P3728CAS No.: 800379-41-3Interleukin II (60-70) is a 60-70 fragment of the cytokine Interleukin II polypeptide.
-
Anti-CD1a Antibody (OKT-6)
0 ImagesCat. No.: HY-P990869Anti-CD1a Antibody (OKT-6) is an anti-human CD1a IgG1 monoclonal antibody. Anti-CD1a Antibody (OKT-6) blocks T cell activation by blocking CD1a function. Anti-CD1a Antibody (OKT-6) can reduce the production of IFN-γ. Anti-CD1a Antibody (OKT-6) can be used for researches on cancer and inflammation such as leukemia. The recommend isotype control of Anti-CD1a Antibody (OKT-6): Mouse IgG1 kappa, Isotype Control (HY-P99977).
-
PHI-501
0 ImagesCat. No.: HY-153858CAS No.: 2470433-36-2PHI-501 is a dual inhibitor targeting RAF/DDR. PHI-501 exhibits significant anti-proliferative effects in melanoma cell lines and significantly inhibits the colony formation of drug-resistant cells. PHI-501 strongly inhibits ERK and AKT phosphorylation. PHI-501 downregulates the gene sets in drug-resistant cells of TNFA-NFKB, IL6-JAK-STAT3, and KRAS signaling pathways as well as the epithelial-mesenchymal transition (EMT) signaling pathways. PHI-501 demonstrates significant anti-tumor effects in the SK-MEL3DR xenograft model. PHI-501 can be used for research on the problem of drug resistance in melanoma.
-
HSP90α-IN-1
0 ImagesCat. No.: HY-173337CAS No.: 184897-90-3HSP90α-IN-1 is a HSP90α inhibitor (IC50 = 111 nM) that exhibits senolytic activity across various cellular senescence models. HSP90α-IN-1 is related to the xanthinic family. HSP90α-IN-1 is involved in research on combating age-related inflammaging and diseases, including cancer, and possibly extend a healthy lifespan.
-
Diacerein (Standard)
0 ImagesSynonyms: Diacerhein(Standard); Diacetylrhein (Standard)Diacerein (Standard) is the analytical standard of Diacerein. This product is intended for research and analytical applications. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.
-
DPP-1-IN-2
0 ImagesCat. No.: HY-181513DPP-1-IN-2 is a DPP-I inhibitor with a human IC50 of 36.8 nM and oral efficacy. DPP-1-IN-2 binds to intracellular DPP-I, increases its thermal stability, and reduces the activity and expression levels of downstream neutrophil serine proteases by inhibiting its enzymatic activity. DPP-1-IN-2 regulates the secretion of inflammatory factors and chemokines to exert anti-inflammatory effects. DPP-1-IN-2 reverses joint inflammation and tissue damage in adjuvant-induced arthritis rat models. DPP-1-IN-2 is applicable to research related to arthritis.
-
IIIM1
0 ImagesCat. No.: HY-P11046CAS No.: 500217-51-6IIIM1 is an orally active anti-inflammatory peptide. IIIM1 ameliorates the symptoms of experimental autoimmune encephalomyelitis (EAE) by stimulating the proliferation of regulatory T cells and inducing them to produce RA1, and regulating the cytokine balance. IIIM1 can be used in the research of multiple sclerosis (MS).
-
PDE/TRPA1/CHIT1-IN-1
0 ImagesCat. No.: HY-179503PDE/TRPA1/CHIT1-IN-1 is a phosphodiesterases (PDEs), TRPA1, and hCHIT1 (KD of 37.7 μM) inhibitor. PDE/TRPA1/CHIT1-IN-1 is a broad-spectrum PDE inhibitor, potently targeting key isoforms including PDE4B, PDE7A, PDE3A, and PDE8A with IC50s of 15.54, 15.15, 8.39 and 16.46 μM. PDE/TRPA1/CHIT1-IN-1 suppresses NLRP3 inflammasome activation and inhibits NF-κB phosphorylation, downregulating the expression of pro-inflammatory genes (TNF-α and IL-6) in vivo. PDE/TRPA1/CHIT1-IN-1 can be used for chronic obstructive pulmonary disease (COPD) and related inflammatory lung disorders research.
-
ADP-β-S
0 ImagesCat. No.: HY-134353CAS No.: 35094-45-2Synonyms: Adenosine 5'-(β-thiodiphosphate)ADP-β-S (Adenosine 5'-(β-thiodiphosphate)) is a non-hydrolyzable ADP analog and a P2Y12 receptor agonist. ADP-β-S activates the P2Y12 receptor in microglia, thereby triggering downstream inflammatory signaling pathways. ADP-β-S activates P2Y purinergic receptors in rat pancreatic β cells and enhances glucose-induced insulin secretion. ADP-β-S can be used in the research of diseases such as inflammation and diabetes.
-
Picfeltarraenin IA (Standard)
0 ImagesCat. No.: HY-N1474RCAS No.: 97230-47-2Picfeltarraenin IA (Standard) is the analytical standard of Picfeltarraenin IA (HY-N1474). This product is intended for research and analytical applications. Picfeltarraenin IA is an Acetylcholinesterase inhibitor. Picfeltarraenin IA can be extracted from the plant Picria fel-terrae Lour. Picfeltarraenin IA reduces the production of IL-8 and PGE2. Picfeltarraenin IA inhibits COX2 via the NF-κB pathway. Picfeltarraenin IA can be used in the research of respiratory system diseases.
-
NPSR1 antagonist-1
0 ImagesCat. No.: HY-175813CAS No.: 3113770-74-1NPSR1 antagonist-1 is a potent and peripherally restricted neuropeptide S receptor 1 (NPSR1) antagonist. NPSR1 antagonist-1 can inhibit IL-6, PTGS2, IL-20, and CXCL8 expression. NPSR1 antagonist-1 can reduce TNF-α cytokine levels. NPSR1 antagonist-1 can be used for the research of inflammation, such as peritonitis.
-
PF-04308515
0 ImagesCat. No.: HY-120510CAS No.: 1206876-95-0Synonyms: PF 4308515PF-04308515 is a glucocorticoid receptor ligand. PF-04308515 inhibits IL-6, IFNγ production. PF-04308515 induces weak PGC1α interaction. PF-04308515 has antiinflammatory activities.
-
GSTO1-IN-6
0 ImagesCat. No.: HY-179635CAS No.: 3114128-67-2GSTO1-IN-6 is an allosteric and covalent GSTO1 inhibitor with an IC50 of 457 nM. GSTO1-IN-6 markedly reduces Lipopolysaccharides (LPS) (HY-D1056)-induced IL-1β (IC50 of 1.9 μM) and IL-18 (IC50 of 10. μM) secretion in human monocyte-derived macrophages. GSTO1-IN-6 covalently modifies GSTO1-Cys32, inducing conformational changes and protein destabilization. GSTO1-IN-6 can be used for the research of inflammatory diseases.
-
IMM20324
0 ImagesCat. No.: HY-P991468IMM20324 is a human monoclonal antibody (mAb) targeting IL38. IMM20324 inhibits the interaction of IL-38 with human IL1RAPL1-Fc and human IL-36R-Fc with IC50 values of 1.267 nM and 1.4667 nM, respectively. IMM20324 has antitumor activity in the B16.F10 syngeneic mouse model. IMM20324 can be used in antitumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).
-
PDE4-IN-18
0 ImagesCat. No.: HY-162797PDE4-IN-18 (compound 1l) is a PDE4 inhibitor (IC50=1.55 μM) with anti-inflammatory activity. PDE4-IN-18 exerts anti-inflammatory effects by reducing excessive immune cell infiltration and intestinal membrane formation, as well as reducing the mRNA expression of pro-inflammatory cytokines (such as TNF-α and IL-6) in synovial tissue. PDE4-IN-18 can be used in the study of rheumatoid arthritis and psoriasis.
-
Magnesium sulfate heptahydrate, for molecular biology
0 ImagesCat. No.: HY-W094477DCAS No.: 10034-99-8Synonyms: Epsom salts, for molecular biologyMagnesium sulfate heptahydrate (for molecular biology) is a molecular biology-grade form of Magnesium sulfate (HY-Y1267). Magnesium sulfate is a calcium antagonist and a potent L-type calcium channel inhibitor, as well as a uterine contraction inhibitor. Magnesium sulfate has anti-inflammatory, anticonvulsant, vasodilatory, and neuroprotective effects. Magnesium sulfate can be used in research on diseases such as preeclampsia/eclampsia.
-
IDO1-IN-34
0 ImagesCat. No.: HY-183317IDO1-IN-34 is a selective IDO1 inhibitor with an IC50 of 0.093 μM. IDO1-IN-34 exhibits cytotoxicity against various cancer cell lines. IDO1-IN-34 inhibits the kynurenine (kynurenine) pathway and activates IL-2. IDO1-IN-34 induces cell apoptosis via the endogenous mitochondrial pathway, while increasing the levels of cytochrome c, caspase-3, caspase-9 and PARP-1. IDO1-IN-34 can be used for research on liver cancer, lung cancer, breast cancer, prostate cancer, colon cancer and leukemia.
