PARP
poly ADP ribose polymerase
PARP is a family of proteins involved in a number of cellular processes involving mainly DNA repair and programmed cell death. The PARP family comprises 17 members. They have all very different structures and functions in the cell. PARP1, PARP2, VPARP (PARP4), Tankyrase-1 and -2 (PARP-5a or TNKS, and PARP-5b or TNKS2) have a confirmed PARP activity. Others include PARP3, PARP6, TIPARP (or PARP7), PARP8, PARP9, PARP10, PARP11, PARP12, PARP14, PARP15, and PARP16. PARP is found in the cell’s nucleus. The main role is to detect and signal single-strand DNA breaks (SSB) to the enzymatic machinery involved in the SSB repair.
PARP Isoform Specific Products
-
PARP
(307)
View all products
-
PARP1
(212)
View all products
-
PARP2
(84)
View all products
-
PARP3
(23)
View all products
-
PARP4
(11)
View all products
-
TNKS1/
PARP5A (41)View all products
-
TNKS2/
PARP5B (38)View all products
-
PARP7
(25)
View all products
-
PARP10
(20)
View all products
-
PARP14
(17)
View all products
-
PARP15
(14)
View all products
-
PARP12
(4)
View all products
-
PARP16
(3)
View all products
All Product Categories
-
PARP Inhibitors
(464)
View all products
-
PARP Agonists
(4)
View all products
-
PARP Activators
(111)
View all products
-
PARP Modulators
(13)
View all products
-
PARP Inducers
(20)
View all products
-
PARP Degraders
(25)
View all products
-
PARP Substrate
(1)
View all products
-
PARP Ligands
(4)
View all products
-
PARP Related Products (702)
Related Products (702)
-
Antibodies (11)
-
PARP Isoform Comparison
-
LS-75
0 ImagesLS-75 is a PARP-1 inhibitor with blood-brain permeability and IC50 value of 18 μM. LS-75 has neuroprotective activity.
-
KU-0058684
0 ImagesKU-0058684 is a potent PARP inhibitor, with an IC50 of 3.2 nM for PARP-1. KU-0058684 significantly reduces DNA double strand break (DSB) repair.
-
Rucaparib tartrate
0 ImagesCat. No.: HY-10617CCAS No.: 773059-22-6Synonyms: AG-014699 tartrate; PF-01367338 tartrateRucaparib (AG014699) tartrate is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib tartrate is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib tartrate has the potential for castration-resistant prostate cancer (CRPC) research.
-
Rucaparib camsylate
0 ImagesCat. No.: HY-102003ACAS No.: 1327258-57-0Synonyms: AG014699 camsylate; PF-01367338 camsylateRucaparib (AG014699) camsylate is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib camsylate is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib camsylate has the potential for castration-resistant prostate cancer (CRPC) research.
-
Sorafenib-d4
0 ImagesSynonyms: Bay 43-9006-d4Sorafenib-d4 (Bay 43-9006-d4) is the deuterated-labeled Sorafenib (HY-10201). Sorafenib (Bay 43-9006) is a potent oral active multikinase inhibitor. Sorafenib blocks autophosphorylation and activity of receptor tyrosine kinases (VEGFR-2, VEGFR-3) and RAF family kinases, thereby suppressing the RAF/MEK/ERK and PI3K/Akt pathways, inhibiting STAT3 phosphorylation, and selectively inhibiting the MAPK pathway in cancer cells. Sorafenib induces cell cycle arrest, autophagy, apoptosis, and PARP cleavage, reduces Bcl-2, Bcl-XL, cyclin D1 levels, and activates Bak and Bax. Sorafenib inhibits tumor growth and metastasis in mouse and rat models. Sorafenib can be used for cancer research, such as colon, breast, non-small-cell lung cancer (NSCLC), ovarian, pancreatic, melanoma, colorectal and hepatocellular carcinoma.
-
PARP1-IN-5
0 ImagesCat. No.: HY-132297CAS No.: 2735645-53-9PARP1-IN-5 is a low toxicity, orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 can be used for the research of cancer.
-
Venadaparib hydrochloride
0 ImagesCat. No.: HY-137457ACAS No.: 1681020-60-9Synonyms: IDX-1197 hydrochlorideVenadaparib (IDX-1197) hydrochloride is a potent and selective PARP inhibitor with anticancer activities. Venadaparib hydrochloride can be used for solid tumors research.
-
Rucaparib acetate
0 ImagesCat. No.: HY-10617DCAS No.: 773059-23-7Synonyms: AG014699 acetate; PF-01367338 acetateRucaparib (AG014699) acetate is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib acetate is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib acetate has the potential for castration-resistant prostate cancer (CRPC) research.
-
Nesuparib hydrochloride
0 ImagesCat. No.: HY-145584ACAS No.: 2055357-65-6Synonyms: JPI-547/OCN-201 hydrochloride
-
Rucaparib hydrochloride
0 ImagesCat. No.: HY-10617BCAS No.: 773059-19-1Synonyms: AG014699 hydrochloride; PF-01367338 hydrochlorideRucaparib (AG014699) hydrochloride is an orally active, potent inhibitor of PARP proteins (PARP-1, PARP-2 and PARP-3) with a Ki of 1.4 nM for PARP1. Rucaparib hydrochloride is a modest hexose-6-phosphate dehydrogenase (H6PD) inhibitor. Rucaparib hydrochloride has the potential for castration-resistant prostate cancer (CRPC) research.
-
Nudifloramide-d6
0 ImagesCat. No.: HY-113432S1CAS No.: 2012598-72-8Synonyms: 2PY-d6
-
Anticancer agent 71
0 ImagesCat. No.: HY-147906CAS No.: 2453228-45-8Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity.
-
2-Methylquinazolin-4-ol (Standard)
0 Images2-Methylquinazolin-4-ol (Standard) is the analytical standard of 2-Methylquinazolin-4-ol. This product is intended for research and analytical applications. 2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2].
-
PARP/VEGFR3-IN-1
0 ImagesCat. No.: HY-179020PARP/VEGFR3-IN-1 (Compound 18) is a dual PARP-VEGFR3 target inhibitor. Its IC50 values for PARP1, PARP2, and VEGFR3 are 0.0763, 0.0366, and 4.25 nM respectively. PARP/VEGFR3-IN-1 has no inhibitory effect on VEGFR1/2 and shows subtype selectivity. PARP/VEGFR3-IN-1 exhibits significant anti-proliferative activity in various cancer cells (leukemia, lung cancer, and triple-negative breast cancer). PARP/VEGFR3-IN-1 induces DNA damage and cell cycle arrest. PARP/VEGFR3-IN-1 triggers various forms of cell death by inducing apoptosis and autophagy. PARP/VEGFR3-IN-1 can be formulated into nanodelivery systems, significantly enhancing tumor targeting and therapeutic window.
-
AKT-IN-28
0 ImagesCat. No.: HY-174254CAS No.: 3099809-16-9AKT-IN-28 is an Akt allosteric inhibitor, a derivative of Shikonin (HY-N0822). AKT-IN-28 effectively binds to the allosteric site of Akt through hydrophobic and hydrogen interactions with Kd of 2.07 μM. AKT-IN-28 significantly inhibits Akt activity, induces cell apoptosis, arrests cell cycle in G2/M phase, and suppresses proliferation, migration and metabolism of KRAS mutant colorectal cancer cells.
-
PARP7-IN-19
0 ImagesCat. No.: HY-163492CAS No.: 3033778-34-3
-
PARP7-IN-27
0 ImagesCat. No.: HY-189217CAS No.: 3051563-45-9PARP7-IN-27 is a blood-brain barrier-permeable and selective PARP7 inhibitor with an IC50 of 22.8 nM. PARP7-IN-27 alleviates neuroinflammation and astrocyte activation, mitigates autophagy-related alterations, reduces the levels of ischemia-associated pro-inflammatory factors, and maintains the expression of synaptic markers. PARP7-IN-27 can be used in studies related to ischemic stroke.
-
Lerzeparib
0 ImagesCat. No.: HY-156623CAS No.: 2459693-01-5Lerzeparib is an (ADP-ribose) polymerase (PARP) inhibitor, with antineoplastic activity.
-
PARP1-IN-9
0 ImagesCat. No.: HY-149001CAS No.: 2494000-71-2PARP1-IN-9 (Compound 5c) is a PARP1 inhibitor with an IC50 of 30.51 nM. PARP1-IN-9 induces cell apoptosis and shows anticancer activity. PARP1-IN-9 has higher potency than Olaparib (HY-10162) .
