Reverse Transcriptase
Reverse transcriptases (RTs) are enzyme used to generate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. Reverse transcriptases (RTs) use an RNA template and a short primer complementary to the 3' end of the RNA to direct the synthesis of the first strand cDNA.
Nucleoside reverse transcriptase inhibitors (NRTIs) block reverse transcriptase (an HIV enzyme). Non-nucleoside reverse transcriptase inhibitors (NNRTIs) bind to and block HIV reverse transcriptase. HIV uses reverse transcriptase to convert its RNA into DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription prevents HIV from replicating.
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Reverse Transcriptase Related Products (265)
Related Products (265)
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HIV RT-IN-2
0 ImagesCat. No.: HY-185449CAS No.: 1909302-89-1HIV RT-IN-2 is a HIV reverse transcriptase inhibitor with an IC50 value of 1.2 μM for HIV-1 RT RNA-dependent DNA polymerase. HIV RT-IN-2 potently inhibits all three modes of HIV-1 RT-associated RNase H activity (internal, 3'-DNA directed, 5'-RNA directed cleavage) and inhibits HIV-1 replication. HIV RT-IN-2 can be used for the research of HIV-1 infection.
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I-XW-053 sodium
0 ImagesCat. No.: HY-103078ACAS No.: 1644644-89-2I-XW-053 sodium is a specific anti-HIV-1 capsid inhibitor (IC50=164.2 μM). By binding to the CA NTD-NTD hexamerization interface and the R173 region of CTD (Kd=66.3 μM), I-XW-053 sodium disrupts capsid function and reduces polymerization levels. I-XW-053 sodium effectively blocks HIV-1 uncoating, inhibits reverse transcription and early replication, and exhibits broad-spectrum activity against primary HIV-1 isolates in peripheral blood mononuclear cells. I-XW-053 sodium can be widely used in studies related to HIV-1 infection.
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NNRT-IN-16
0 ImagesCat. No.: HY-182916NNRT-IN-16, Rilpivirin (HY-10574) analogue, is a non-nucleoside reverse transcriptase inhibitor (NNRTI). NNRT-IN-16 inhibits recombinant WT HIV-1 RT with an IC50 of 0.07 μM. NNRT-IN-16 exerts antiviral activity against wild-type and drug-resistant HIV-1 mutants, shows attenuated CYP isoenzyme and hERG inhibition, reduced cytotoxicity, and improved metabolic stability in human liver microsomes. NNRT-IN-16 can be used for the research of HIV-1 infection.
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PNU-103657
0 ImagesCat. No.: HY-105372CAS No.: 179556-43-5PNU-103657 (Compound 13) is an orally active reverse transcriptase inhibitor (IC50 = 0.51 μM (WT)). PNU-103657 has antiviral activity. PNU-103657 can be used in research on infections and immune system diseases such as HIV infection.
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DPC-082
0 ImagesCat. No.: HY-167135CAS No.: 214287-98-6DPC-082 is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI) of HIV-1. DPC-082 inhibits wild-type RF virus with an IC90 of 2.0 nM. DPC-082 inhibits various single and many multiple amino acid substituted HIV-1 mutant viruses.
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Lamivudine triphosphate
0 ImagesCat. No.: HY-131603CAS No.: 143188-53-8Synonyms: 3TCTPLamivudine triphosphate (3TCTP) is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate inhibits the reverse transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA.
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Morin 3-O-β-D-glucopyranoside
0 ImagesCat. No.: HY-N10411CAS No.: 1169766-14-6Morin 3-O-β-D-glucopyranoside is a natural flavonoid with antifungal, anticancer and antioxidant activities. Morin 3-O-β-D-glucopyranoside inhibits reverse transcriptase, protein-tyrosine kinase and xanthine oxidase, and also shows anti-HIV, antiarteriosclerotic, and superoxide scavenging activities.
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Fosalvudine tidoxil
0 ImagesCat. No.: HY-14922CAS No.: 763903-67-9
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HIV-IN-15
0 ImagesCat. No.: HY-184924CAS No.: 3102264-65-0HIV-IN-15 is a HIV-infected cell killer, with an EC50 of 20 nM in the HIV-TACK assay. HIV-IN-15 binds to the reverse transcriptase p66 domain of monomeric GAG-POL, accelerates the dimerization process, and selectively kills HIV-infected cells expressing GAG-POL, with no cytotoxicity against HIV-uninfected cells. HIV-IN-15 can be used for research on HIV infection, acquired immunodeficiency syndrome (AIDS), or AIDS-related complex (ARC).
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Niglizin
0 ImagesCat. No.: HY-19493CAS No.: 85734-94-7Niglizin is a noncompetitive inhibitor of reverse transcriptase. Niglizin can effectively suppress the HIV replication and shows synergetic effect companied with Zidovudine (HY-17413). Niglizin can be used for the research of HIV infection.
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Elvucitabine
0 ImagesCat. No.: HY-117582CAS No.: 181785-84-2Elvucitabine is an L-nucleoside analogue. Elvucitabine is a potent nucleoside reverse transcriptase (RT) inhibitor. Elvucitabine can be used in research of viral infection.
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Etravirine-13C3
0 ImagesCat. No.: HY-W777351CAS No.: 1189671-48-4Synonyms: R165335-13C3; TMC125-13C3Etravirine-13C3 (R165335-13C3) is the 13C-labeled Etravirine (HY-90005). Etravirine (R165335; TMC125) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
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Dapivirine-d11
0 ImagesCat. No.: HY-14266SCAS No.: 1329613-10-6Synonyms: TMC120-d11; R147681-d11Dapivirine-d11 is the deuterium labeled Dapivirine. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations.
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HIV-1 inhibitor-50
0 ImagesCat. No.: HY-152160CAS No.: 2834087-69-1
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Peruvianoside II
0 ImagesCat. No.: HY-N16888CAS No.: 450407-31-5Peruvianoside II is a flavanone glucoside compound. Peruvianoside II shows no inhibitory activity against both HIV-1 reverse transcriptase and HIV-1 integrase at concentrations below 100 μM. Peruvianoside II can be extracted from the leaves of Thevetia peruviana.
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Rilpivirine-d6 hydrochloride
0 ImagesCat. No.: HY-10574ASCAS No.: 2714324-67-9Rilpivirine-d6 (hydrochloride) is the deuterium labeled Rilpivirine hydrochloride.
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HI-280
0 ImagesCat. No.: HY-105386CAS No.: 240417-31-6HI-280 is a human immunodeficiency virus type 1 (HIV-1) reverse transcriptase inhibitor. HI-280 can be used for the research of infection.
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Metacavir
0 ImagesCat. No.: HY-116154CAS No.: 120503-45-9Metacavir is an orally active, potent and specific nucleoside reverse transcriptase inhibitor against hepatitis B virus (HBV) with antiviral activity.
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Efavirenz (Standard)
0 ImagesSynonyms: DMP 266 (Standard); EFV (Standard); L-743726 (Standard)Efavirenz (Standard) is the analytical standard of Efavirenz. This product is intended for research and analytical applications. Efavirenz (DMP 266) is a potent inhibitor of the wild-type HIV-1 reverse transcriptase with a Ki of 2.93 nM and exhibits an IC95 of 1.5 nM for the inhibition of HIV-1 replicative spread in cell culture.
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Dapivirine (Standard)
0 ImagesSynonyms: TMC120 (Standard); R147681 (Standard)Dapivirine (Standard) is the analytical standard of Dapivirine. This product is intended for research and analytical applications. Dapivirine (TMC120), the prototype of diarylpyrimidines (DAPY), is an orally active and nonnucleoside reverse transcriptase inhibitor (NRTI). Dapivirine (TMC120) binds directly to HIV-1 reverse transcriptase. Dapivirine (TMC120) regulates autophagy and induced Akt, Bad and SAPK/JNK activations.
