mGluR
Metabotropic glutamate receptors
mGluR (metabotropic glutamate receptor) is a type of glutamate receptor that are active through an indirect metabotropic process. They are members of thegroup C family of G-protein-coupled receptors, or GPCRs. Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatoryneurotransmitter. The mGluRs perform a variety of functions in the central and peripheral nervous systems: mGluRs are involved in learning, memory, anxiety, and the perception of pain. mGluRs are found in pre- and postsynaptic neurons in synapses of the hippocampus, cerebellum, and the cerebral cortex, as well as other parts of the brain and in peripheral tissues. Eight different types of mGluRs, labeled mGluR1 to mGluR8, are divided into groups I, II, and III. Receptor types are grouped based on receptor structure and physiological activity.
mGluR Isoform Specific Products
All Product Categories
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mGluR Related Products (404)
Related Products (404)
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Antibodies (8)
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mGluR Isoform Comparison
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MTEP hydrochloride (Standard)
0 ImagesMTEP (hydrochloride) (Standard) is the analytical standard of MTEP (hydrochloride). This product is intended for research and analytical applications. MTEP hydrochloride is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP hydrochloride shows antidepressant and anxiolytic-like effects. MTEP hydrochloride can be used for Parkinson's disease research.
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(Rac)-LSN2814617
0 ImagesCat. No.: HY-118256ACAS No.: 1313498-08-6(Rac)-LSN2814617 is a racemate of LSN2814617 (HY-118256).
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LY379268 (Standard)
0 ImagesCat. No.: HY-103558RCAS No.: 191471-52-0LY379268 (Standard) is the analytical standard of LY379268 (HY-103558). This product is intended for research and analytical applications. LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3). LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects.
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Oxomemazine hydrochloride
0 ImagesOxomemazine hydrochloride is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine hydrochloride is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki= 84 nM, M1 receptor) and low (Ki= 1.65 μM, M2 receptor) affinity sites[1]. Oxomemazine hydrochloride an antihistamine and anticholinergic agent used for the study of cough treatment.
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ACPT-II
0 ImagesCat. No.: HY-101387ACAS No.: 195209-04-2ACPT-II is an antagonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects.
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VU0029251
0 ImagesCat. No.: HY-125717CAS No.: 330819-85-7
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Mavoglurant (Standard)
0 ImagesSynonyms: AFQ056 (Standard)Mavoglurant (Standard) is the analytical standard of Mavoglurant. This product is intended for research and analytical applications. Mavoglurant (AFQ056) is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant can be used for the research of Fragile X syndrome (FXS), and L-dopa induced dyskinesias in Parkinson's disease. Mavoglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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PF-06422913
0 ImagesCat. No.: HY-135441CAS No.: 1539296-46-2PF-06422913 is an orally active, potent and selective metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.
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LY2389575 hydrochloride (Standard)
0 ImagesCat. No.: HY-107509RCAS No.: 885104-09-6LY2389575 hydrochloride (Standard) is the analytical standard of LY2389575 (hydrochloride) (HY-107509). This product is intended for research and analytical applications. LY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease.
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Lu AF21934 (Standard)
0 ImagesCat. No.: HY-100366RCAS No.: 1445605-23-1Lu AF21934 (Standard) is the analytical standard of Lu AF21934 (HY-100366). This product is intended for research and analytical applications. Lu AF21934 is a selective and brain-penetrant mGlu4 receptor positive allosteric modulator with an EC50 of 500 nM for mGlu4 receptor.
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Ro 01-6128 (Standard)
0 ImagesCat. No.: HY-107507RCAS No.: 302841-86-7Ro 01-6128 (Standard) is the analytical standard of Ro 01-6128 (HY-107507). This product is intended for research and analytical applications. Ro 01-6128 is a positive allosteric modulator of mGluR1.
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CFMTI (Standard)
0 ImagesCat. No.: HY-100402RCAS No.: 864864-17-5
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Ro 67-7476 (Standard)
0 ImagesCat. No.: HY-100403RCAS No.: 298690-60-5Ro 67-7476 (Standard) is the analytical standard of Ro 67-7476 (HY-100403). This product is intended for research and analytical applications. Ro 67-7476 is a potent positive allosteric modulator of mGluR1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC50 of 60.1 nM. Ro 67-7476 is a potent P-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM).
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Homo-AMPA
0 ImagesCat. No.: HY-189015CAS No.: 179169-88-1Homo-AMPA is a stereospecific mGluR6 agonist (EC50 = 58 μM) and a weak NMDA (HY-17551) receptor antagonist (IC50 = 131 μM), exerting anxiolytic-like effects and modulating pain-responsive neuronal activity through selective activation of mGluR6. Homo-AMPA can serve as a standard agonist for the pharmacological characterization of mGluR6 in related studies.
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Desmethyl-YM-298198
0 ImagesCat. No.: HY-103567ACAS No.: 299901-57-8Desmethyl-YM-298198 is a high-affinity, selective, and noncompetitive mGluR1 antagonist (IC50: 16 nM). Desmethyl-YM-298198 has analgesic effect in Streptozotocin (HY-13753)-induced hyperalgesic mice.
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BMT-145027 (Standard)
0 ImagesCat. No.: HY-100728RCAS No.: 2018282-44-3BMT-145027 (Standard) is the analytical standard of BMT-145027 (HY-100728). This product is intended for research and analytical applications. BMT-145027 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM.
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NPS 2390 (Standard)
0 ImagesCat. No.: HY-11095RCAS No.: 226878-01-9
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A-850002
0 ImagesCat. No.: HY-111256CAS No.: 869802-73-3
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VU0400195
0 ImagesCat. No.: HY-120567CAS No.: 1309434-83-0Synonyms: ML182VU0400195 (ML182) is a oral active and allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4) with the EC50 of 291 nM. VU0400195 can be used for study of antiparkinsonian animal model.
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(E)-PHCCC
0 ImagesCat. No.: HY-111332CAS No.: 177610-87-6(E)-PHCCC is a positive allosteric modulator (PAM) for mGluR4, that enhances the activity of the receptor's endogenous ligand (glutamate), and exhibits activity in the calcium mobilization assay in CHO cells with an EC50 of 3.2 μM.
