Canthin-6-one
Based on 1 Customer Validation
Canthin-6-one is an indole alkaloid, displays antibacterial and anti-inflammatory activities.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.92%
- CAS. Nr.: 479-43-6
- Formel: C14H8N2O
- Molecular Weight:220.23
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Speicherung:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | ED50 |
3.6 μg/mL
Compound: 5
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Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
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[PMID: 14575431] |
| ADR5000 cell line | IC50 |
10.52 μM
Compound: 25
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Cytotoxicity against human multidrug-resistant CEM/ADR5000 cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay
Cytotoxicity against human multidrug-resistant CEM/ADR5000 cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay
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[PMID: 34332400] |
| C6 | EC50 |
15 μM
Compound: 1
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Antiproliferative activity against rat C6 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
Antiproliferative activity against rat C6 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
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[PMID: 25379743] |
| Calu-3 | CC50 |
>100 μM
Compound: Table 1, R11C2
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Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
Cytotoxicity against human Calu-3 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
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[PMID: 36399766] |
| CCRF-CEM | IC50 |
15.82 μM
Compound: 25
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Cytotoxicity against human drug sensitive CCRF-CEM cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay
Cytotoxicity against human drug sensitive CCRF-CEM cells assessed as fluorescence incubated for 72 hrs by resazurin reduction assay
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[PMID: 34332400] |
| DU-145 | IC50 |
9.43 μg/mL
Compound: 25
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Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human DU-145 cells incubated for 48 hrs by MTT assay
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[PMID: 34332400] |
| HCC1395 | IC50 |
8.12 μg/mL
Compound: 25
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Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay
Antiproliferative activity against human HCC1395 cells incubated for 48 hrs by MTT assay
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[PMID: 34332400] |
| HCT-8 | CC50 |
42.41 μM
Compound: Table 1, R11C2
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Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay
Cytotoxicity against human HCT-8 cells assessed as redcution in cell viability incubated for 96 hrs by PrestoBlue reagent based assay
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[PMID: 36399766] |
| HeLa | EC50 |
15 μM
Compound: 1
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Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
Antiproliferative activity against human HeLa cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
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[PMID: 25379743] |
| HepG2 | CC50 |
85.65 μM
Compound: Table 1, R11C2
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
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[PMID: 36399766] |
| HT-29 | EC50 |
15 μM
Compound: 1
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Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
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[PMID: 25379743] |
| Jurkat | EC50 |
15 μM
Compound: 1
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Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
Antiproliferative activity against human Jurkat cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
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[PMID: 25379743] |
| Keratinocyte | IC50 |
1.11 μg/mL
Compound: 25
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Cytotoxicity against guinea pig ear keratinocytes using [3H]thymidine by liquid scintillation counting analysis
Cytotoxicity against guinea pig ear keratinocytes using [3H]thymidine by liquid scintillation counting analysis
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[PMID: 34332400] |
| MCF7 | ED50 |
7.3 μg/mL
Compound: 5
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Cytotoxicity against human MCF7 cells by SRB assay
Cytotoxicity against human MCF7 cells by SRB assay
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[PMID: 14575431] |
| MRC5 | CC50 |
91.16 μM
Compound: Table 1, R11C2
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
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[PMID: 36399766] |
| NHDF | EC50 |
115 μM
Compound: 1
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Toxicity against human NHDF assessed as reduction in cell viability incubated for 3 days by MTT assay
Toxicity against human NHDF assessed as reduction in cell viability incubated for 3 days by MTT assay
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[PMID: 25379743] |
| NIH3T3 | EC50 |
15 μM
Compound: 1
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Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
Antiproliferative activity against mouse NIH/3T3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
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[PMID: 25379743] |
| PC-3 | EC50 |
15 μM
Compound: 1
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Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
Antiproliferative activity against human PC3 cells assessed as inhibition of cell growth at 10 to 60 uM after 4 days
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[PMID: 25379743] |
| Vero | CC50 |
>100 μM
Compound: Table 1, R11C2
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by PrestoBlue reagent based assay
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[PMID: 36399766] |
Canthin-6-one exhibits antibacterial activity against Mycobacterium sp. and Staphylococcus sp. with MIC of 8-32 µg/mL[1].
Canthin-6-one (0.5-5 µM, 25 h) inhibits LPS (HY-D1056)-induced expression of iNOS, COX-2, MCP-1, TNF-α and IL-6, and inhibits the phosphorylation of IκB and Akt in RAW 264.7 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW 264.7
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Concentration:0.5-5 µM
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Incubation Time:25 h
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Result:Inhibited the expression of iNOS, COX-2, p-IκB and p-Akt.
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Cell Line:RAW 264.7
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Concentration:0.5-5 µM
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Incubation Time:25 h
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Result:Downregulated the expression of iNOS, COX-2, MCP-1, TNF-α and IL-6.
Chemical Information
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CAS. Nr. 479-43-6
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Appearance Solid
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Molecular Weight 220.23
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Formel C14H8N2O
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Color White to light yellow
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SMILES
O=C1N2C3=C(N=CC=C3C4=C2C=CC=C4)C=C1
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Lösungsmittel & Löslichkeit
DMSO : 25 mg/mL (113.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. O'Donnell G, Gibbons S. Antibacterial activity of two canthin-6-one alkaloids from Allium neapolitanum. Phytother Res. 2007;21(7):653-657. [Content Brief]
[2]. Cho SK, et al., Anti-inflammatory Effects of Canthin-6-one Alkaloids from Ailanthus altissima. Planta Med. 2018 May;84(8):527-535. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.5407 mL | 22.7035 mL | 45.4071 mL | 113.5177 mL |
| 5 mM | 0.9081 mL | 4.5407 mL | 9.0814 mL | 22.7035 mL | |
| 10 mM | 0.4541 mL | 2.2704 mL | 4.5407 mL | 11.3518 mL | |
| 15 mM | 0.3027 mL | 1.5136 mL | 3.0271 mL | 7.5678 mL | |
| 20 mM | 0.2270 mL | 1.1352 mL | 2.2704 mL | 5.6759 mL | |
| 25 mM | 0.1816 mL | 0.9081 mL | 1.8163 mL | 4.5407 mL | |
| 30 mM | 0.1514 mL | 0.7568 mL | 1.5136 mL | 3.7839 mL | |
| 40 mM | 0.1135 mL | 0.5676 mL | 1.1352 mL | 2.8379 mL | |
| 50 mM | 0.0908 mL | 0.4541 mL | 0.9081 mL | 2.2704 mL | |
| 60 mM | 0.0757 mL | 0.3784 mL | 0.7568 mL | 1.8920 mL | |
| 80 mM | 0.0568 mL | 0.2838 mL | 0.5676 mL | 1.4190 mL | |
| 100 mM | 0.0454 mL | 0.2270 mL | 0.4541 mL | 1.1352 mL |
Canthin-6-one Related Classifications
HY-N3536 Related Classifications
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