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iMDK quarterhydrate

7 Cited Publications
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Based on 7 publication(s) in Google Scholar

iMDK quarterhydrate is a potent PI3K inhibitor and inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate suppresses non-small cell lung cancer (NSCLC) cooperatively with A MEK inhibitor without harming normal cells and mice.

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  • Reinheit: 99.37%
  • Formel: C21H13FN2O2S.1/4H2O
  • Molecular Weight:380.91
  • Speicherung:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • iMDK quarterhydrate Chemical Structure
    iMDK quarterhydrate Chemical Structure
  • Experimental Validation Results for iMDK quarterhydrate
  • Experimental Validation Results for iMDK quarterhydrate
  • Experimental Validation Results for iMDK quarterhydrate
  • Experimental Validation Results for iMDK quarterhydrate
  • Experimental Validation Results for iMDK quarterhydrate
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In Vivo Efficacy StudyHistological Imaging/StainingRT-PCRCell Proliferation/Viability Assay
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  • In Vivo Efficacy Study
  • Histological Imaging/Staining
  • RT-PCR
  • Cell Proliferation/Viability Assay

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  • iMDK quarterhydrate Chemical Structure
    iMDK quarterhydrate Chemical Structure
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  • 1/16

    iMDK quarterhydrate purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Oct 22;10(1):110. [Abstract]

    Customer Validation
     iMDK (9 mg/kg, intraperitoneally injected, once a day from E7.5 to E12.5.). Placental efficiency as expressed by the ratio of fetal weight to placental weight (n = 24 for control, n = 41 for iMDK).

  • 1/16

    iMDK quarterhydrate purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Oct 22;10(1):110. [Abstract]

    Customer Validation
     iMDK (9 mg/kg, intraperitoneally injected, once a day from E7.5 to E12.5.). Measurements of the labyrinth area and JZ area and the ratio of the labyrinth area to the JZ area (n = 8 control, n = 14 iMDK).

  • 1/16

    iMDK quarterhydrate purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Oct 22;10(1):110. [Abstract]

    Customer Validation
     iMDK (9 mg/kg, intraperitoneally injected, once a day from E7.5 to E12.5.). Representative image of a cross-section through the labyrinth and JZ in a mid-section of a mouse placenta. The blue solid line outlines the labyrinth and JZ that was measured.

  • 1/16

    iMDK quarterhydrate purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Oct 22;10(1):110. [Abstract]

    Customer Validation
     iMDK (9 mg/kg, intraperitoneally injected, once a day from E7.5 to E12.5.). Real-time quantitative polymerase chain reaction (RT-qPCR) analysis of the expression of markers of SynT-I (Mct1) and endothelial cells (Cd31). RT-qPCR data were normalized to the reference gene Hprt.

  • 1/16

    iMDK quarterhydrate purchased from MedChemExpress. Usage Cited in: Cell Discov. 2024 Oct 22;10(1):110. [Abstract]

    Customer Validation
     The CCK-8 assay was used to evaluate the proliferation of endothelial cells treated with iMDK (0.125-1 μM).

  • iMDK quarterhydrate