Art. -Nr.: HY-N0528

Linarin

(Synonyms: Buddleoside; Linarine)

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). Linarin has many activities, such as anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial and antiviral. Linarin can be used to study diseases such as the nervous system, osteoporosis and cancer.

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Reinheit: 98.02%
CAS. Nr.: 480-36-4
Formel: C₂₈H₃₂O₁₄
Molecular Weight:592.55

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Linarin Chemical Structure

CAS. Nr.: 480-36-4

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

AChE

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen :

AChE
BChE

Alle PKA Isoform-spezifische Produkte anzeigen :

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-22	EC₅₀	69.3 μM Compound: 8	Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay Neuroprotective activity against glutamate-induced cell death in mouse HT-22 cells assessed as increase in cell viability after 24 hrs by EZ-Cytox assay	[PMID: 32991171]
RAW264.7	CC₅₀	>100 μM Compound: 25	Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay	[PMID: 33667099]
RAW264.7	IC₅₀	>100 μM Compound: 25	Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay	[PMID: 33667099]
RAW264.7	IC₅₀	10.02 μM Compound: 10	Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method Inhibition of NO production in LPS-stimulated mouse RAW264.7 cells pre-incubated for 2 hrs before LPS stimulation for 24 hrs by Griess assay method	[PMID: 25176187]

In Vitro

Linarin (25-100 μM; 24-72 h) inhibits the growth of human prostate cancer cells (LNCaP and DU145) and induces apoptosis^[1].
Linarin (0.1-10 μM; 6-21 days) activates the BMP-2/RUNX2 pathway through PKA signal transduction, and then induces osteogenic differentiation and mineralization of MC3T3-E1 osteoblasts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

MC3T3-E1 cells
Concentration:

0.1, 1 and 10 μM
Incubation Time:

48 h
Result:

Dose-dependently increased BMP-2 and RUNX2 protein levels.

Western Blot Analysis^[2]

Cell Line:

MC3T3-E1 cells
Concentration:

0.1, 1 and 10 μM
Incubation Time:

6, 12, 24 and 48 h
Result:

Markedly stimulated PKA protein expression in a time- and dose-dependent manner.

In Vivo

Linarin (oral administration; 50-150 mg/kg; 8 weeks) can improve bone loss in ovariectomized mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Ovariectomy treated female C57/BL6 mice^[2]
Dosage:

50 and 150 mg/kg
Administration:

Oral administration (p.o.); 8 weeks
Result:

Dose‑dependently preserved the trabecular bone microarchitecture of ovariectomized mice.
Slightly increased BMD compared to the control OVX group.
Significantly decreased OVX-induced serum ALP and OCN levels.

Chemical Information

CAS. Nr. 480-36-4
Appearance Solid
Molecular Weight 592.55
Formel C₂₈H₃₂O₁₄
Color White to off-white
SMILES

O=C(C=C(C1=CC=C(OC)C=C1)OC2=CC(O[C@@H]([C@@H]([C@@H](O)[C@@H]3O)O)O[C@@H]3CO[C@H](O[C@@H](C)[C@H](O)[C@H]4O)[C@@H]4O)=C5)C2=C5O
Synonyms

Buddleoside; Linarine
Structure Classification
- Flavonoids
- Flavones
Initial Source
- Plants
- Labiatae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (4)

All Cell Proliferation/Viability AssayIFFlow CytometryWBCell Imaging/Staining

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Journal Impact Factor

Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
Ind Crops Prod

2025 Dec 11;239:122458.
Pharmaceuticals (Basel)

Herba Patriniae Component Linarin Induces Cell Cycle Arrest and Senescence in Non-Small-Cell Lung Cancer Associated with Cyclin A2 Downregulation. [Abstract]

2026 Jan 8;19(1):111. PMID: 41599710

Linarin purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2026 Jan 8;19(1):111. [Abstract]

A549 cells were treated with the indicated doses of Linarin for 24 and 48 h to assess cell viability.

Linarin purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2026 Jan 8;19(1):111. [Abstract]

A549 cells were treated with the indicated doses of Linarin (100, 200 μM) for 24 h, followed by EdU experiments to evaluate cell proliferation.

Linarin purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2026 Jan 8;19(1):111. [Abstract]

Flow cytometric analysis of cell cycle in A549 cells treated with the indicated doses of Linarin (100, 200 μM) for 24 h. The percentages of cells in G0/G1, S, and G2/M phases are indicated within each panel.

Linarin purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2026 Jan 8;19(1):111. [Abstract]

Representative Western blot images showing the expression of key cell cycle proteins (CDK1/4, CCNA2/B1 (Cyclin A2/B1), CHEK1/2 (Chk1/2)) in A549 cells treated with Linarin (100, 200 μM).

Linarin purchased from MedChemExpress. Usage Cited in: Pharmaceuticals (Basel). 2026 Jan 8;19(1):111. [Abstract]

SA-β-gal staining of H1299 cells treated with Linarin (100, 200 μM).

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 250 mg/mL (421.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.6876 mL

8.4381 mL

16.8762 mL

5 mM

0.3375 mL

1.6876 mL

3.3752 mL

10 mM

0.1688 mL

0.8438 mL

1.6876 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (3.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (3.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (3.51 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (281 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Singh RP, et al. Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate. Carcinogenesis. 2005 Apr;26(4):845-54. [Content Brief]

[2]. Li J, et al. Linarin promotes osteogenic differentiation by activating the BMP-2/RUNX2 pathway via protein kinase A signaling. Int J Mol Med. 2016 Apr;37(4):901-10. [Content Brief]

[3]. Päivi P. Oinonen,etc. Linarin, a selective acetylcholinesterase inhibitor from Mentha arvensis, Fitoterapia,Volume 77, Issue 6, 2006, Pages 429-434, ISSN 0367-326X [Content Brief]

[4]. Mottaghipisheh J, et al. Linarin, a Glycosylated Flavonoid, with Potential Therapeutic Attributes: A Comprehensive Review. Pharmaceuticals (Basel). 2021 Oct 29;14(11):1104. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.6876 mL	8.4381 mL	16.8762 mL	42.1905 mL
	5 mM	0.3375 mL	1.6876 mL	3.3752 mL	8.4381 mL
	10 mM	0.1688 mL	0.8438 mL	1.6876 mL	4.2191 mL
	15 mM	0.1125 mL	0.5625 mL	1.1251 mL	2.8127 mL
	20 mM	0.0844 mL	0.4219 mL	0.8438 mL	2.1095 mL
	25 mM	0.0675 mL	0.3375 mL	0.6750 mL	1.6876 mL
	30 mM	0.0563 mL	0.2813 mL	0.5625 mL	1.4064 mL
	40 mM	0.0422 mL	0.2110 mL	0.4219 mL	1.0548 mL
	50 mM	0.0338 mL	0.1688 mL	0.3375 mL	0.8438 mL
	60 mM	0.0281 mL	0.1406 mL	0.2813 mL	0.7032 mL
	80 mM	0.0211 mL	0.1055 mL	0.2110 mL	0.5274 mL
	100 mM	0.0169 mL	0.0844 mL	0.1688 mL	0.4219 mL

Keywords

Linarin

4 Cited Publications

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Linarin

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Publications Citing Use of MedChemExpress (MCE) Linarin

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Alle Cholinesterase (ChE) Isoform-spezifische Produkte anzeigen

Alle PKA Isoform-spezifische Produkte anzeigen

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Linarin Related Classifications

HY-N0528 Related Classifications