Lucidin
Based on 1 publication(s) in Google Scholar
Lucidin (NSC 30546) is a natural component of madder and can induce mutations in bacterial and mammalian cells.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.03%
- CAS. Nr.: 478-08-0
- Formel: C15H10O5
- Molecular Weight:270.24
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Publications Citing Use of MedChemExpress (MCE) Lucidin
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Biologische Aktivität
Lucidin (0-30 μg/mL, 1 h) induces unprogrammed DNA synthesis in rat hepatocytes, induces single-strand DNA breaks and DNA-protein crosslinking in V79 cells, causes DNA damage and mutations[1].
Lucidin (0-30 μg/mL) induces malignant transformation of C3H/M2 mouse fibroblasts and forms transformation foci, exhibits potential carcinogenicity[1].
Lucidin (23 μM, 48 h) inhibits HPV E6, prevents the degradation of p53 protein, increases the protein expression of Bax, and activates caspase 3/7. Lucidin inhibits the cell viability of HeLa and Caski (IC50s are 23 μM and 45 μM), induces apoptosis in HeLa cell[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 478-08-0
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Appearance Solid
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Molecular Weight 270.24
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Formel C15H10O5
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Color Light yellow to yellow
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SMILES
O=C1C2=C(C=CC=C2)C(C3=CC(O)=C(CO)C(O)=C13)=O
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Synonyms
NSC 30546
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
DMSO : 6.67 mg/mL (24.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Westendorf J, et al. The genotoxicity of lucidin, a natural component of Rubia tinctorum L., and lucidinethylether, a component of ethanolic Rubia extracts. Cell Biol Toxicol. 1988 Jun;4(2):225-39. [Content Brief]
[2]. Westendorf J, et al. Carcinogenicity and DNA adduct formation observed in ACI rats after long-term treatment with madder root, Rubia tinctorum L. Carcinogenesis. 1998 Dec;19(12):2163-8. [Content Brief]
[3]. Gomes D, et al., Taxifolin and Lucidin as Potential E6 Protein Inhibitors: p53 Function Re-Establishment and Apoptosis Induction in Cervical Cancer Cells. Cancers (Basel). 2022 Jun 8;14(12):2834. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7004 mL | 18.5021 mL | 37.0041 mL | 92.5104 mL |
| 5 mM | 0.7401 mL | 3.7004 mL | 7.4008 mL | 18.5021 mL | |
| 10 mM | 0.3700 mL | 1.8502 mL | 3.7004 mL | 9.2510 mL | |
| 15 mM | 0.2467 mL | 1.2335 mL | 2.4669 mL | 6.1674 mL | |
| 20 mM | 0.1850 mL | 0.9251 mL | 1.8502 mL | 4.6255 mL |
Lucidin Related Classifications
HY-15733 Related Classifications
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