Cat. No.: HY-N0626

Sorbic acid

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Based on 1 Customer Validation

Sorbic acid is an antibacterial preservative effective against most molds, yeasts, and some bacterial species. Sorbic acid inhibits microbial growth. Sorbic acid suppresses the activity of intestinal microorganisms in zebrafish, alters the composition of intestinal flora, and reduces the levels of intestinal immune biomarkers, including IgG, IL-1β, and TNF-α. Sorbic acid can be used in research on the prevention and treatment of mold, yeast, and bacterial infections.

For research use only. We do not sell to patients.

Purity: 99.98%
CAS No.: 110-44-1
Formula: C₆H₈O₂
Molecular Weight:112.13

Storage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Sorbic acid Chemical Structure

CAS No.: 110-44-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

All Antibiotic Isoforms :

In Vitro

Sorbic acid (0.05%-0.1%) extends the shelf life of cottage cheese, inhibits the growth of Penicillium frequentans and other spoilage microorganisms, suppresses spoilage bacteria in cottage cheese as well as molds in unsalted butter and grains, and prolongs the safe storage period of grains^[1].
Sorbic acid (0.02%-0.04%) inhibits the growth of molds in ham and sausage, as well as the growth of Aspergillus versicolor, inhibits the growth of Alternaria solani, Penicillium citrinum and Aspergillus niger, with minimum inhibitory concentrations of 0.02%, 0.08% and 0.08%, respectively^[1].
Sorbic acid (0.05-0.15%) delays or prevents spore germination and growth initiation of Aspergillus parasiticus and Aspergillus flavus strains, slows their hyphal growth, inhibits the growth of Aspergillus sulphureus and Penicillium viridicatum as well as their ability to produce ochratoxin A, and reduces or even blocks the production of aflatoxin B1 by Aspergillus parasiticus and Aspergillus flavus^[1].
Sorbic acid (0.05%) inhibits the growth of Zygosaccharomyces rouxii, Saccharomyces bisporus, Saccharomyces acidifaciens and Saccharomyces pastorianus, and is used in combination with acids^[1].
Incorporation of Sorbic acid (≥15%) into sweet potato starch films significantly inhibits the growth of E. coli, but exerts no inhibitory effect on S. aureus^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Exposure to Sorbic acid (0.1-1 g/L; aqueous exposure; daily water replacement; 14 days) inhibits intestinal microbial activity, alters intestinal flora composition, and reduces the levels of intestinal immune biomarkers, including IgG, IL-1β, and TNF-α^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Danio rerio (4-month-old adults)^[2]
Dosage:

0.1 g/L; 1 g/L
Administration:

aqueous exposure; daily water replacement; 14 days
Result:

Decreased levels of intestinal IgG, IL-1β, and TNF-α.
Altered core gut microbiota development, with Pelomonas becoming the most abundant genus (accounting for 32.77% of gut microbiota), while Reyranella and Sphingomonas decreased, and Rhizobacter increased.
Decreased relative abundance of transcription, energy metabolism, and cancer pathways.
Significantly reduced the gut microbiota activity index (AIM).

Chemical Information

CAS No. 110-44-1
Appearance Solid
Molecular Weight 112.13
Formula C₆H₈O₂
Color White to off-white
SMILES

C/C=C/C=C/C(O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Plants
- other families
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (445.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

8.9182 mL

44.5911 mL

89.1822 mL

5 mM

1.7836 mL

8.9182 mL

17.8364 mL

10 mM

0.8918 mL

4.4591 mL

8.9182 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (22.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (22.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (22.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liewen MB, et al. Growth and Inhibition of Microorganisms in the Presence of Sorbic Acid: A Review. J Food Prot. 1985;48(4):364-375. [Content Brief]

[2]. Peng Q, et al. Potassium sorbate suppresses intestinal microbial activity and triggers immune regulation in zebrafish (Danio rerio). Food Funct. 2019;10(11):7164-7173. [Content Brief]

[3]. Xiao Li Shen, et al. Antimicrobial and physical properties of sweet potato starch films
incorporated with potassium sorbate or chitosan. Food Hydrocolloids, June 2010, 285-290.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	8.9182 mL	44.5911 mL	89.1822 mL	222.9555 mL
	5 mM	1.7836 mL	8.9182 mL	17.8364 mL	44.5911 mL
	10 mM	0.8918 mL	4.4591 mL	8.9182 mL	22.2956 mL
	15 mM	0.5945 mL	2.9727 mL	5.9455 mL	14.8637 mL
	20 mM	0.4459 mL	2.2296 mL	4.4591 mL	11.1478 mL
	25 mM	0.3567 mL	1.7836 mL	3.5673 mL	8.9182 mL
	30 mM	0.2973 mL	1.4864 mL	2.9727 mL	7.4319 mL
	40 mM	0.2230 mL	1.1148 mL	2.2296 mL	5.5739 mL
	50 mM	0.1784 mL	0.8918 mL	1.7836 mL	4.4591 mL
	60 mM	0.1486 mL	0.7432 mL	1.4864 mL	3.7159 mL
	80 mM	0.1115 mL	0.5574 mL	1.1148 mL	2.7869 mL
	100 mM	0.0892 mL	0.4459 mL	0.8918 mL	2.2296 mL

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Sorbic acid

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All Endogenous Metabolite Isoforms

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Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Sorbic acid Related Classifications

HY-N0626 Related Classifications