BRD4 degrader-6
BRD4 degrader-6 is a dimeric BDR4 PROTAC degrader (DC50: < 0.1 μM). BRD4 degrader-6 promotes the ubiquitination and degradation of BDR4 and has anticancer activity.
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- CAS No.: 3055207-38-7
- 화학식: C61H71BClN9O7S2
- 분자량:1152.67
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
제품 설명
IC50 & Target
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BRD4 <0.1 μM (DC50) |
In Vitro
BRD4 degrader-6 (example 1) (1.5 nM, Pre-treatment 2h, re-treatment 24h) can effectively degrade BDR4 in BRD4 HiBiT cells (DC50: < 0.11 μM)[1].
BRD4 degrader-6 relies on the reversibility of the bond to dissociate into monomers in vitro and in vivo, allowing them to enter cells and then re-form dimers inside the cells, where they then bind to target proteins and induce ubiquitin-mediated degradation of the target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3055207-38-7
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분자량 1152.67
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화학식 C61H71BClN9O7S2
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SMILES
ClC1=CC=C(C=C1)C2=N[C@H](C3=NN=C(N3C4=C2C(C)=C(S4)C)C)CC(NCC[C@@]56[C@@H]7C[C@H](C[C@@H]5OB(O6)C8=C(C=CC=C8)CCC(N[C@H](C(N9C[C@@H](C[C@H]9C(NCC%10=CC=C(C=C%10)C%11=C(N=CS%11)C)=O)O)=O)C(C)(C)C)=O)C7(C)C)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BRD4 degrader-6 Related Classifications
HY-173327 Related Classifications
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