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Cat. No.: HY-119787

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α-Rubromycin

Name: α-Rubromycin
Brand: MedChemExpress
SKU: HY-119787
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(Synonyms: Collinomycin)

α-Rubromycin (Collinomycin) is an antibiotic isolated from the mycelia of Streptomyces collinus. α-Rubromycin also acts as a DNA polymerase inhibitor, with an IC₅₀ of 0.91 μM against bovine mammalian DNA polymerase. α-Rubromycin binds to the active region of DNA polymerase β, competes with nucleotide substrates for binding, and interferes with template-DNA interactions. α-Rubromycin inhibits the activities of telomerase, retroviral reverse transcriptase and terminal deoxynucleotidyl transferase, as well as the growth of Staphylococcus aureus. α-Rubromycin can be used in studies related to bacterial infections.

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CAS No.: 27267-69-2
Formule: C₂₇H₂₀O₁₂
Masse moléculaire:536.44

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Please store the product under the recommended conditions in the Certificate of Analysis.

α-Rubromycin Chemical Structure

CAS No.: 27267-69-2

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

IC₅₀ & Target

^[1]

DNA Polymerases

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	EC₅₀	>100 μM Compound: 6	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 31833370]
A549	EC₅₀	100 μM Compound: 6	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 31833370]
PC-3	EC₅₀	>100 μM Compound: 6	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 31833370]
PC-3	EC₅₀	100 μM Compound: 6	Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay Antiproliferative activity against human PC3 cells assessed as reduction in cell viability after 72 hrs by alamar blue assay	[PMID: 31833370]

In Vitro

α-Rubromycin potently and selectively inhibits mammalian DNA polymerase α and β, with the strongest inhibitory effect on rat DNA polymerase β (IC₅₀ = 0.45 μM). Its mechanism of action involves binding to the 31 kDa catalytic domain and competing with nucleotide substrates for binding, while it does not interfere with the binding of DNA templates^[1].
α-Rubromycin (compound 1) inhibits M-MLV RT with an IC₅₀ of 7.34 μM; it shows almost no activity against human immunodeficiency virus type 1 (HIV-1) reverse transcriptase, with an IC₅₀ > 200 μM; it also exhibits extremely weak inhibitory effect on human telomerase, with an IC₅₀ > 200 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 27267-69-2
Masse moléculaire 536.44
Formule C₂₇H₂₀O₁₂
SMILES

O=C(OC)C1=CC2=CC(CCC3=CC(C(C4=C5C(O)=C(C=C4OC)OC)=O)=C(O3)C5=O)=C(C(O)=C2C(O1)=O)O
Synonyms

Collinomycin
Structure Classification
- Quinones
- Naphthalene Quinones
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Streptomyces collinus
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Mizushina Y, et al. The biochemical mode of inhibition of DNA polymerase β by α‑rubromycin. Biochimica et Biophysica Acta, 2000, 1523:172‑181.

[2]. Atkinson DJ, et al. Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products. Natural product reports. 2015 Jun;32(6):811-40.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Chemical Information
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α-Rubromycin

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