Cefonicid
Cefonicid is a long-acting cephalosporin antibiotic. Cefonicid also acts as a noncompetitive class I β-lactamase inhibitor with a Ki value of 0.8 μM. Cefonicid exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid can be used for research on infections.
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- CAS No.: 61270-58-4
- Formule: C18H18N6O8S3
- Masse moléculaire:542.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
In Vitro
Cefonicid (25-200 mg/L; 3-6 days) dose-dependently inhibits the proliferation of human PBMCs stimulated by FLU, XENO, ALLO, and PHA (HY-N7038)[1].
Cefonicid (0-200 mg/L; 7 days) dose-dependently inhibits IL-2 production by human PBMC stimulated with FLU, XENO and ALLO[1].
Cefonicid (0-24 h) exhibits concentration-dependent bactericidal activity against Klebsiella pneumoniae strain 2603 in vitro, with an MIC of 0.25 mg/L[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Cefonicid (40 mg/kg; single dose) exhibits excellent protective effects against S. aureus, E. coli, P. mirabilis, and K. pneumoniae infections in mice[4].
Cefonicid exerts excellent preventive protective effects against surgical wound infections in mice, with an ED50 value of ≤2.1 mg/kg against Gram-negative bacilli and an ED50 value ranging from 3.7 to 8.7 mg/kg against S. aureus[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Hartley (female, 220-250 g)[3]
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Dosage:15 mg/kg
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Administration:i.p.; 2 doses (immediately and 24 hours post-challenge)
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Result:Showed similar lung bacterial counts to infected untreated controls at 0 and 1 hour post-challenge.
Reduced lung bacterial counts significantly compared to infected untreated controls starting at 6 hours post-challenge, with significant reductions also seen at 24 and 48 hours post-challenge.
Chemical Information
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CAS No. 61270-58-4
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Masse moléculaire 542.57
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Formule C18H18N6O8S3
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SMILES
O=C(O)C(N12)=C(CSC3=NN=NN3CS(=O)(O)=O)CS[C@]2([H])[C@H](NC([C@H](O)C4=CC=CC=C4)=O)C1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Villa ML, et al. Interference of cephalosporins with immune response: effects of cefonicid on human T-helper cells. Int J Immunopharmacol. 1991;13(8):1099-1107. [Content Brief]
[4]. Saltiel E, et al. Cefonicid. A review of its antibacterial activity, pharmacological properties and therapeutic use. Drugs. 1986;32(3):222-259. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cefonicid Related Classifications
HY-B1300A Related Classifications
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