dCeMM4
Based on 1 Customer Validation
dCeMM4 is a Cyclin K Molecular glue degrader. dCeMM4 mediates the direct interaction between CDK12:cyclin K and the CRL4B ligase complex, thereby driving the ubiquitination and proteasomal degradation of Cyclin K. dCeMM4 induces Apoptosis without cell cycle phase-specific arrest. dCeMM4 exhibits synergistic activity with DNA damage inducers, and a correlation exists between Cyclin K degradation and cellular sensitivity. dCeMM4 can be used in studies related to T-cell malignancies.
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- Pureté : 98.01%
- CAS No.: 1281683-44-0
- Formule: C14H15N3O3S2
- Masse moléculaire:337.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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HY-144976
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Activité biologique
Description
IC50 & Target
[1]|
CDK12/Cyclin K |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:wildtype KBM7 cells
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Concentration:3.5 μM
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Incubation Time:4 h, 8 h, 12 h
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Result:Induced profound apoptosis in wildtype KBM7 cells.
Caused no phase-specific cell-cycle arrest.
Chemical Information
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CAS No. 1281683-44-0
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Appearance Solid
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Masse moléculaire 337.42
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Formule C14H15N3O3S2
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Color Light yellow to yellow
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SMILES
CC1=CC=C(O1)C(N2CSCC2C(/N=C3NC=C(S/3)C)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
In Vitro:
DMSO : 3.33 mg/mL (9.87 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (290 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Jochem M, et al. Degradome analysis to identify direct protein substrates of small-molecule degraders. Cell chemical biology. 2025 Jan 16;32(1):192-200.e6. [Content Brief]
[2]. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling. Nature chemical biology. 2020 Nov;16(11):1199-1207. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9637 mL | 14.8183 mL | 29.6367 mL | 74.0916 mL |
| 5 mM | 0.5927 mL | 2.9637 mL | 5.9273 mL | 14.8183 mL |
dCeMM4 Related Classifications
HY-144977 Related Classifications
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