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Cat. No.: HY-190189

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DS22

DS22 is a CDK12-cyclin K molecular glue degrader. DS22 promotes the formation of the DDB1-CDK12-cyclin K ternary complex, with an EC₅₀ of 19 nM. DS22 can be used in research related to CDK12-mediated diseases, such as cancer.

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CAS No.: 3068547-01-0
Formule: C₂₁H₂₂Cl₂N₁₀O
Masse moléculaire:501.37

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Please store the product under the recommended conditions in the Certificate of Analysis.

DS22 Chemical Structure

CAS No.: 3068547-01-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

CDK12/Cyclin K

1316 nM (IC₅₀)

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In Vitro

Cell Cycle Regulation

DS22 (compound 67) promotes DDB1-CDK12-cyclin K ternary complex formation in vitro, with a TR-FRET EC₅₀ of 19 nM^[1].
DS22 binds CDK12-cyclin K in the Lanthascreen kinase binding assay with an IC₅₀ of 1316 nM, and shows weaker activity against CDK2-cyclin A and CDK9-cyclin T (both IC₅₀ >10000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3068547-01-0
Masse moléculaire 501.37
Formule C₂₁H₂₂Cl₂N₁₀O
SMILES

CC[C@@H](NC1=NC(NCC2=NC3=CC(Cl)=C(Cl)C=C3N2)=C4C(N(C5=CN(C)N=C5)C=N4)=N1)CO
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Kozicka Z, et al. Design principles for cyclin K molecular glue degraders. Nature chemical biology. 2024 Jan;20(1):93-102. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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DS22

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