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Cat. No.: HY-121511

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EML631

EML631 is a SPIN1 inhibitor with a K_d of 3-7 μM. EML631 interacts with the second Tudor domain of SPIN1 and blocks its ability to read the H3K4me3 histone mark. EML631 inhibits the coactivator activity of SPIN1 in the Wnt signaling pathway and reduces the activity of Wnt response reporter genes. EML631 can be used in cancer-related research.

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CAS No.: 2101206-36-2
Formule: C₄₁H₆₀N₆O₃
Masse moléculaire:684.97

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Please store the product under the recommended conditions in the Certificate of Analysis.

EML631 Chemical Structure

CAS No.: 2101206-36-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Epigenetic Reader Domain :

Voir tous les produits spécifiques à Isoform Wnt :

In Vitro

EML631 (15-30 mM), like SPIN-DOC, blocks the H3K4me3 reading ability of SPIN1 in T778 cells and exerts identical effects on Wnt signaling pathway activity^[1].
EML631 specifically binds to the Tudor domain of SPIN1, with a K_d value of 3-7 μM as measured by ITC^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2101206-36-2
Masse moléculaire 684.97
Formule C₄₁H₆₀N₆O₃
SMILES

O=C(C1=CC=C(C(=O)N2CCC(CC2)CCN3CCCC3)C(=C1)NC4=CC=C(OCN5CCCC5)C=C4)N6CCC(CC6)CCN7CCCC7
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Bae N, et al. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. J Biol Chem. 2017;292(51):20808-20817. [Content Brief]

[2]. Uguen M, et al. Tudor-Containing Methyl-Lysine and Methyl-Arginine Reader Proteins: Disease Implications and Chemical Tool Development. ACS Chem Biol. 2025;20(1):33-47. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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- In Vitro
Chemical Information
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EML631

Voir tous les produits spécifiques à Isoform Epigenetic Reader Domain

Voir tous les produits spécifiques à Isoform Wnt

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

EML631 Related Classifications

HY-121511 Related Classifications