CDK18 - cyclin dependent kinase 18 Gene

Also Known as PCTK3; PCTAIRE; PCTAIRE3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5129

About CDK18

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,504,669-205,532,790 (from NCBI)

This gene has 23 transcripts (splice variants), 198 orthologues and 26 paralogues. Broad expression in heart (RPKM 26.3), brain (RPKM 20.4) and 20 other tissues.

Summary

Predicted to enable ATP binding activity; cyclin-dependent protein serine/threonine kinase activity; and protein serine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CDK18 Products (3)

mRNA Protein Name
NM_002596.4 NP_002587.2 cyclin-dependent kinase 18 isoform b
NM_212502.3 NP_997667.1 cyclin-dependent kinase 18 isoform b
NM_212503.3 NP_997668.1 cyclin-dependent kinase 18 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of myelination IDA
IDA: Inferred from direct assay
31028571 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK18 Protein Structure

Pkinase

Pkinase: Protein kinase domain (174 - 455)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 18

  • PCTAIRE protein kinase 3

CDK18 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
CDK18 Q07002 CCDC102B Homo sapiens Q68D86
Y2H Prey Pooling
25416956
Intra
CDK18 Q07002 CCDC102B Homo sapiens Q68D86
Y2H Array
25416956
Intra
CDK18 Q07002 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
CDK18 Q07002 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
CDK18 Q07002 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
CDK18 Q07002 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 ZNF774 Homo sapiens Q6NX45
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 ZNF774 Homo sapiens Q6NX45
Y2H Array
32296183
Intra
CDK18 Q07002 ZNF774 Homo sapiens Q6NX45
Validated Y2H
32296183
Intra
CDK18 Q07002 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
CDK18 Q07002 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
CDK18 Q07002 HOOK2 Homo sapiens Q96ED9-2
Validated Y2H
32296183
Intra
CDK18 Q07002 HOOK2 Homo sapiens Q96ED9-2
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 HOOK2 Homo sapiens Q96ED9-2
Y2H Array
32296183
Intra
CDK18 Q07002 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra
CDK18 Q07002 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
Intra
CDK18 Q07002 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra
CDK18 Q07002 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 CBY2 Homo sapiens Q8NA61-2
Validated Y2H
32296183
Intra
CDK18 Q07002 CBY2 Homo sapiens Q8NA61-2
Y2H Array
32296183
Intra
CDK18 Q07002 CBY2 Homo sapiens Q8NA61-2
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 CDR2 Homo sapiens Q01850
Y2H Array
32296183
Intra
CDK18 Q07002 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 FCHSD2 Homo sapiens O94868-3
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 FCHSD2 Homo sapiens O94868-3
Y2H Array
32296183
Intra
CDK18 Q07002 ZNF438 Homo sapiens Q7Z4V0
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 ZNF438 Homo sapiens Q7Z4V0
Validated Y2H
32296183
Intra
CDK18 Q07002 ZNF438 Homo sapiens Q7Z4V0
Y2H Array
32296183
Intra
CDK18 Q07002 CCDC125 Homo sapiens Q86Z20
Validated Y2H
32296183
Intra
CDK18 Q07002 CCDC125 Homo sapiens Q86Z20
Y2H Array
32296183
Intra
CDK18 Q07002 CCDC125 Homo sapiens Q86Z20
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 CCNK Homo sapiens O75909-2
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 CCNK Homo sapiens O75909-2
Y2H Array
32296183
Intra
CDK18 Q07002 VPS28 Homo sapiens Q9UK41-2
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 VPS28 Homo sapiens Q9UK41-2
Y2H Array
32296183
Intra
CDK18 Q07002 VPS28 Homo sapiens Q9UK41-2
Validated Y2H
32296183
Intra
CDK18 Q07002 EYA2 Homo sapiens O00167-2
Y2H Array
32296183
Intra
CDK18 Q07002 EYA2 Homo sapiens O00167-2
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra
CDK18 Q07002 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra
CDK18 Q07002 KIFC3 Homo sapiens Q9BVG8
Y2H Prey Pooling
25416956
Intra
CDK18 Q07002 KIFC3 Homo sapiens Q9BVG8
Y2H Array
25416956
Intra
CDK18 Q07002 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
25416956
Intra
CDK18 Q07002 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
25416956
Intra
CDK18 Q07002 BLZF1 Homo sapiens Q9H2G9
Validated Y2H
32296183
Intra
CDK18 Q07002 BLZF1 Homo sapiens Q9H2G9
Y2H Array
32296183
Intra
CDK18 Q07002 BLZF1 Homo sapiens Q9H2G9
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 HMBOX1 Homo sapiens Q6NT76
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 HMBOX1 Homo sapiens Q6NT76
Y2H Array
32296183
Intra
CDK18 Q07002 HMBOX1 Homo sapiens Q6NT76
Validated Y2H
32296183
Intra
CDK18 Q07002 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 KANK2 Homo sapiens Q63ZY3
Validated Y2H
32296183
Intra
CDK18 Q07002 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
Intra
CDK18 Q07002 VPS52 Homo sapiens Q8N1B4
Validated Y2H
32296183
Intra
CDK18 Q07002 VPS52 Homo sapiens Q8N1B4
Y2H Array
32296183
Intra
CDK18 Q07002 VPS52 Homo sapiens Q8N1B4
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
CDK18 Q07002 PNMA1 Homo sapiens Q8ND90
Y2H Array
25416956
Intra
CDK18 Q07002 YWHAZ Homo sapiens P63104
Anti Tag CoIP
33961781
Intra
CDK18 Q07002 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
CDK18 Q07002 CCDC88B Homo sapiens A6NC98
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 CCDC88B Homo sapiens A6NC98
Y2H Array
32296183
Intra
CDK18 Q07002 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra
CDK18 Q07002 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
CDK18 Q07002 KRT16 Homo sapiens P08779
Y2H Array
32296183
Intra
CDK18 Q07002 KRT16 Homo sapiens P08779
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
CDK18 Q07002 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 TRAF1 Homo sapiens Q13077
Validated Y2H
32296183
Intra
CDK18 Q07002 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
CDK18 Q07002 CCND3 Homo sapiens P30281
Y2H Array
32296183
Intra
CDK18 Q07002 RABEP1 Homo sapiens Q15276
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 RABEP1 Homo sapiens Q15276
Validated Y2H
32296183
Intra
CDK18 Q07002 RABEP1 Homo sapiens Q15276
Y2H Array
32296183
Intra
CDK18 Q07002 ZRANB1 Homo sapiens Q9UGI0
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 ZRANB1 Homo sapiens Q9UGI0
Y2H Array
32296183
Intra
CDK18 Q07002 ZRANB1 Homo sapiens Q9UGI0
Validated Y2H
32296183
Intra
CDK18 Q07002 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 FSD2 Homo sapiens A1L4K1
Y2H Array
32296183
Intra
CDK18 Q07002 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
CDK18 Q07002 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra
CDK18 Q07002 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra
CDK18 Q07002 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
CDK18 Q07002 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
CDK18 Q07002 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 INCA1 Homo sapiens Q0VD86
Validated Y2H
32296183
Intra
CDK18 Q07002 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
CDK18 Q07002 HAP1 Homo sapiens P54257
Y2H Array
32296183
Intra
CDK18 Q07002 HAP1 Homo sapiens P54257
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
CDK18 Q07002 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
CDK18 Q07002 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
CDK18 Q07002 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 KRT15 Homo sapiens P19012
Y2H Array
32296183
Intra
CDK18 Q07002 KRT15 Homo sapiens P19012
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 LZTS2 Homo sapiens Q9BRK4
Validated Y2H
25416956
Intra
CDK18 Q07002 LZTS2 Homo sapiens Q9BRK4
Y2H Array
25416956
Intra
CDK18 Q07002 MAD1L1 Homo sapiens Q9Y6D9
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 MAD1L1 Homo sapiens Q9Y6D9
Validated Y2H
32296183
Intra
CDK18 Q07002 MAD1L1 Homo sapiens Q9Y6D9
Y2H Array
32296183
Intra
CDK18 Q07002 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 CEP76 Homo sapiens Q8TAP6
Validated Y2H
32296183
Intra
CDK18 Q07002 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
CDK18 Q07002 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
Intra
CDK18 Q07002 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
CDK18 Q07002 ZNF426 Homo sapiens Q9BUY5
Validated Y2H
32296183
Intra
CDK18 Q07002 ZNF426 Homo sapiens Q9BUY5
Y2H Array
32296183
Intra
CDK18 Q07002 ZNF426 Homo sapiens Q9BUY5
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 PPFIA1 Homo sapiens Q13136
Validated Y2H
32296183
Intra
CDK18 Q07002 PPFIA1 Homo sapiens Q13136
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 PPFIA1 Homo sapiens Q13136
Y2H Array
32296183
Intra
CDK18 Q07002 IKZF3 Homo sapiens Q9UKT9
Y2H Array
32296183
Intra
CDK18 Q07002 IKZF3 Homo sapiens Q9UKT9
Validated Y2H
32296183
Intra
CDK18 Q07002 IKZF3 Homo sapiens Q9UKT9
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Intra
CDK18 Q07002 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra
CDK18 Q07002 CCNDBP1 Homo sapiens O95273
Y2H Array
25416956
Intra
CDK18 Q07002 CCNDBP1 Homo sapiens O95273
Validated Y2H
25416956
Intra
CDK18 Q07002 AK8 Homo sapiens Q96MA6
Validated Y2H
32296183
Intra
CDK18 Q07002 AK8 Homo sapiens Q96MA6
Y2H Array
32296183
Intra
CDK18 Q07002 AK8 Homo sapiens Q96MA6
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 TTC23 Homo sapiens Q5W5X9-3
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 TTC23 Homo sapiens Q5W5X9-3
Validated Y2H
32296183
Intra
CDK18 Q07002 TTC23 Homo sapiens Q5W5X9-3
Y2H Array
32296183
Intra
CDK18 Q07002 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
CDK18 Q07002 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra
CDK18 Q07002 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Intra
CDK18 Q07002 KRT31 Homo sapiens Q15323
Y2H Array
25416956
Intra
CDK18 Q07002 TRIM50 Homo sapiens Q86XT4
Validated Y2H
32296183
Intra
CDK18 Q07002 TRIM50 Homo sapiens Q86XT4
Y2H Prey Pooling
32296183
Intra
CDK18 Q07002 TRIM50 Homo sapiens Q86XT4
Y2H Array
32296183
Intra
CDK18 Q07002 KRT86 Homo sapiens O43790
Y2H Array
32296183
Intra
CDK18 Q07002 KRT86 Homo sapiens O43790
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS28034 Cdk18 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CDK18 VGNC VGNC:68737
Rattus norvegicus CDK18 RGD RGD:1309523
Bos taurus CDK18 VGNC VGNC:27121
Canis familiaris CDK18 VGNC VGNC:39049
Mus musculus CDK18 MGD MGI:97518
Macaca mulatta CDK18 VGNC VGNC:71162
Others CDK18 NCBI