Acyclovir monophosphate
Acyclovir monophosphate is a potent anti-herpes simplex virus (HSV) agent. Acyclovir monophosphate blocks DNA synthesis through the inhibition of the viral DNA polymerase and terminates the chain elongation of the viral DNA. Acyclovir monophosphate shows antitumor activity.
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- CAS. Nr.: 66341-16-0
- Formel: C8H12N5O6P
- Molecular Weight:305.18
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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DNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | EC50 |
20 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
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Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
Antiviral activity against HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
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[PMID: 22954898] |
| Vero | EC50 |
41 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
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Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
Antiviral activity against acyclovir-resistant HSV1 L2 infected in Vero E6 cells assessed as inhibition of virus-induced cytopathic effect after 48 hrs
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[PMID: 22954898] |
| Vero | CC50 |
>2000 μM
Compound: 14, ACV H-phosphonate, ACV monophosphate
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Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue staining
Cytotoxicity against african green monkey Vero E6 cells after 72 hrs by trypan blue staining
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[PMID: 22954898] |
Chemical Information
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CAS. Nr. 66341-16-0
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Molecular Weight 305.18
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Formel C8H12N5O6P
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SMILES
O=C1N=C(NC2=C1N=CN2COCCOP(O)(O)=O)N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Acyclovir monophosphate Related Classifications
HY-17422B Related Classifications
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