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Art. -Nr.: HY-119159

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AS1604498

AS1604498 is a highly specific competitive inhibitor of human NAMPT, with an IC₅₀ of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis. AS1604498 is applicable to research related to chronic myeloid leukemia.

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CAS. Nr.: 361465-74-9
Formel: C₁₉H₁₇N₃O₂
Molecular Weight:319.36

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

AS1604498 Chemical Structure

CAS. Nr.: 361465-74-9

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Biologische Aktivität
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- In Vitro
Chemical Information
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Biologische Aktivität

Beschreibung

Alle Caspase Isoform-spezifische Produkte anzeigen :

In Vitro

AS1604498 (0.032-10 μM; 48 h) inhibits THP-1 human leukemia cell growth with an IC₅₀ of 198 nM, and this effect is reversed by 10 mM Nicotinamide (HY-B0150)^[1].
AS1604498 (0.032-10 μM; 48 h) inhibits K562 human chronic myelogenous leukemia cell growth with an IC₅₀ of 673 nM, and this effect is reversed by 10 mM Nicotinamide^[1].
AS1604498 (10 μM; 48 h) induces delayed caspase 3/7 activation in THP-1 cells, and this activation is reversed by 10 mM Nicotinamide^[1].
AS1604498 (0.001-10 μM; 5 h) reduces intracellular NAD levels in K562 cells in a dose-dependent manner, and this effect is reversed by 10 mM Nicotinamide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

THP-1 human leukemia cell
Concentration:

0.032, 0.1, 0.32, 1, 3.2, 10 μM
Incubation Time:

48 h
Result:

Dose-dependently inhibited THP-1 cell proliferation, with an IC₅₀ of 198 nM (equivalent to 198 nM).
Was completely reversed in growth inhibitory effect by the addition of 10 mM nicotinamide.

Cell Proliferation Assay^[1]

Cell Line:

K562 human chronic myelogenous leukemia cell
Concentration:

0.032, 0.1, 0.32, 1, 3.2, 10 μM
Incubation Time:

48 h
Result:

Dose-dependently inhibited K562 cell proliferation, with an IC₅₀ of 673 nM (equivalent to 673 nM).
Was completely reversed in growth inhibitory effect by the addition of 10 mM nicotinamide.

Chemical Information

CAS. Nr. 361465-74-9
Molecular Weight 319.36
Formel C₁₉H₁₇N₃O₂
SMILES

O=C(NCCCN1C=NC=C1)C=2OC(C#CC=3C=CC=CC3)=CC2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Takeuchi M, et al. Discovery of a novel nicotinamide phosphoribosyl transferase (NAMPT) inhibitor via in silico screening. Biol Pharm Bull. 2014;37(1):31-36. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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AS1604498

Alle Caspase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

AS1604498 Related Classifications

HY-119159 Related Classifications