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Art. -Nr.: HY-168453

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dBAZ2B

dBAZ2B is a BAZ2B PROTAC degrader, with a DC₅₀ of 19 nM. (Pink: BAZ2A/B ligand (HY-168449); Black: linker (HY-168450); Blue: VHL Ligand (HY-125905))
(Pink: ligand (HY-168449); Blue: ligand (HY-125905); Black: linker (HY-168450)).

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CAS. Nr.: 3104449-58-0
Formel: C₅₅H₆₆FN₁₁O₆S
Molecular Weight:1028.25

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

dBAZ2B Chemical Structure

CAS. Nr.: 3104449-58-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
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Biologische Aktivität

Beschreibung

dBAZ2B is a BAZ2B PROTAC degrader, with a DC₅₀ of 19 nM^[1]. (Pink: BAZ2A/B ligand (HY-168449); Black: linker (HY-168450); Blue: VHL Ligand (HY-125905)) (Pink: ligand (HY-168449); Blue: ligand (HY-125905); Black: linker (HY-168450)).

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In Vitro

dBAZ2B binds to purified BAZ2A and BAZ2B bromodomains with K_d values of 4.7 nM and 51 nM, respectively^[1].
dBAZ2B (0.25 μM; 2-72 h) selectively degrades BAZ2B in PC3 cells with a DC₅₀ of 19 nM (Dmax ≥ 95%), increases BAZ2A levels with an EC₅₀ of 35 nM, achieves substantial BAZ2B degradation within 2 h that persists for at least 72 h, and acts via a bromodomain-binding, VHL-dependent, proteasome-mediated mechanism^[1].
dBAZ2B (0.25 μM; 4 h) depletes PT117, SESD1, and BBS7 proteins (an effect linked to BAZ2A bromodomain inhibition) and does not significantly alter BAZ2A levels in this proteomic assay^[1].
dBAZ2B (0.25 μM; 4 h) selectively degrades BAZ2B and increases BAZ2A levels in MM1S cells, demonstrating its cell-line-independent selectivity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 3104449-58-0
Molecular Weight 1028.25
Formel C₅₅H₆₆FN₁₁O₆S
SMILES

CC1=C(SC=N1)C2=CC(OC[C@@H]3CC[C@H](CC3)COCC4=NC(C5=CN(N=C5)C)=C(N4CCC6=CN(N=C6)C)C7=CC=C(C=C7)C#N)=C(C=C2)CNC([C@@H]8C[C@H](CN8C([C@H](C(C)(C)C)NC(C9(CC9)F)=O)=O)O)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Palaferri L, et al. Discovery of First-in-Class BAZ2A/B and BAZ2B-Selective Degraders. ACS Medicinal Chemistry Letters, 2025.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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dBAZ2B

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