EML631
EML631 is a SPIN1 inhibitor with a Kd of 3-7 μM. EML631 interacts with the second Tudor domain of SPIN1 and blocks its ability to read the H3K4me3 histone mark. EML631 inhibits the coactivator activity of SPIN1 in the Wnt signaling pathway and reduces the activity of Wnt response reporter genes. EML631 can be used in cancer-related research.
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- CAS. Nr.: 2101206-36-2
- Formel: C41H60N6O3
- Molecular Weight:684.97
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
EML631 (15-30 mM), like SPIN-DOC, blocks the H3K4me3 reading ability of SPIN1 in T778 cells and exerts identical effects on Wnt signaling pathway activity[1].
EML631 specifically binds to the Tudor domain of SPIN1, with a Kd value of 3-7 μM as measured by ITC[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2101206-36-2
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Molecular Weight 684.97
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Formel C41H60N6O3
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SMILES
O=C(C1=CC=C(C(=O)N2CCC(CC2)CCN3CCCC3)C(=C1)NC4=CC=C(OCN5CCCC5)C=C4)N6CCC(CC6)CCN7CCCC7
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Bae N, et al. A transcriptional coregulator, SPIN·DOC, attenuates the coactivator activity of Spindlin1. J Biol Chem. 2017;292(51):20808-20817. [Content Brief]
[2]. Uguen M, et al. Tudor-Containing Methyl-Lysine and Methyl-Arginine Reader Proteins: Disease Implications and Chemical Tool Development. ACS Chem Biol. 2025;20(1):33-47. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
EML631 Related Classifications
HY-121511 Related Classifications
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