Linalool,98% (stabilized with MEHQ)
Based on 5 publication(s) in Google Scholar
Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.04%
- CAS. Nr.: 78-70-6
- Formel: C10H18O
- Molecular Weight:154.25
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Speicherung:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Linalool,98% (stabilized with MEHQ)
MoreAlle Endogenous Metabolite Isoform-spezifische Produkte anzeigen
MoreAlle iGluR Isoform-spezifische Produkte anzeigen
MoreAlle TNF Receptor Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
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NMDA Receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
55.44 μg/mL
Compound: Linalool
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Cytotoxicity against Homo sapiens (human) HeLa cells up to 3 days by MTT assay
Cytotoxicity against Homo sapiens (human) HeLa cells up to 3 days by MTT assay
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10.1007/s00044-012-0432-0 |
Linalool (0-2000 μM, 24-72 h) can induce apoptosis of cancer cells (U87-MG, HepG-2, SW620 and so on) through oxidative stress while protecting normal cells PC12[3].
Linalool (0-2000 mg/mL, 0-72 h) exerts antibacterial effects by damaging cell membranes[3].
Linalool (0-2 mM, 24-48 h) inhibits A549 cell proliferation by inducing G0/G1 and/or G2/M cell cycle arrest, and without affecting the cell viability of normal lung WI-38 cells. Linalool inhibits A549 cell migration[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:WI-38, A549
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Concentration:0-2 mM
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Incubation Time:24-48 h
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Result:Induced significant G0/G1 cell cycle arrest, accompanied by a strong reduction of S-phase cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sarcoma-180 Solid Tumor Mice Model[5]
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Dosage:150, 200, 250 mg/kg orally every alternate day for 21 days
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Administration:p.o.
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Result:Increased antioxidant enzyme activity in normal liver tissue and decreased liver antioxidant enzyme activity in S-180 tumor carriers.
Chemical Information
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CAS. Nr. 78-70-6
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Appearance Liquid (Density: 0.87 g/cm3)
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Molecular Weight 154.25
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Formel C10H18O
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Color Colorless to light yellow
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SMILES
C=CC(O)(C)CC/C=C(C)/C
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Structure Classification
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Rep
2024 Oct 3;43(10):114800. PMID: 39365703 -
Int Immunopharmacol
Minimolide F alleviates inflammatory diseases by specifically targeting STING and blocking IRF3 recruitment. [Abstract]2026 May 1:176:116468. PMID: 41819671 -
Int J Mol Sci
Differential Effects of the Processed and Unprocessed Garlic (Allium sativum L.) Ethanol Extracts on Neuritogenesis and Synaptogenesis in Rat Primary Hippocampal Neurons. [Abstract]2023 Aug 29;24(17):13386. PMID: 37686193 -
Cell Div
2026 May 18;21(1):15. PMID: 42151974 -
Lösungsmittel & Löslichkeit
DMSO : 100 mg/mL (648.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.21 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Oner Z1, et al. The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats. Hum Exp Toxicol. 2019 Apr 12:960327119842634. [Content Brief]
[2]. Jun HJ, et al. Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110. [Content Brief]
[3]. Jana S, et al. Antitumorigenic potential of linalool is accompanied by modulation of oxidative stress: an in vivo study in sarcoma-180 solid tumor model. Nutr Cancer. 2014;66(5):835-48. [Content Brief]
[4]. Rodenak-Kladniew B, et al. Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells. Heliyon. 2020 Dec 15;6(12):e05639. [Content Brief]
[5]. An Q, et al. Recent updates on bioactive properties of linalool. Food Funct. 2021 Nov 1;12(21):10370-10389. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 6.4830 mL | 32.4149 mL | 64.8298 mL | 162.0746 mL |
| 5 mM | 1.2966 mL | 6.4830 mL | 12.9660 mL | 32.4149 mL | |
| 10 mM | 0.6483 mL | 3.2415 mL | 6.4830 mL | 16.2075 mL | |
| 15 mM | 0.4322 mL | 2.1610 mL | 4.3220 mL | 10.8050 mL | |
| 20 mM | 0.3241 mL | 1.6207 mL | 3.2415 mL | 8.1037 mL | |
| 25 mM | 0.2593 mL | 1.2966 mL | 2.5932 mL | 6.4830 mL | |
| 30 mM | 0.2161 mL | 1.0805 mL | 2.1610 mL | 5.4025 mL | |
| 40 mM | 0.1621 mL | 0.8104 mL | 1.6207 mL | 4.0519 mL | |
| 50 mM | 0.1297 mL | 0.6483 mL | 1.2966 mL | 3.2415 mL | |
| 60 mM | 0.1080 mL | 0.5402 mL | 1.0805 mL | 2.7012 mL | |
| 80 mM | 0.0810 mL | 0.4052 mL | 0.8104 mL | 2.0259 mL | |
| 100 mM | 0.0648 mL | 0.3241 mL | 0.6483 mL | 1.6207 mL |
Linalool,98% (stabilized with MEHQ) Related Classifications
HY-N0368 Related Classifications
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- Linalool,98% (stabilized with MEHQ)
- 78-70-6
- Environmental Pollutants
- Endogenous Metabolite
- iGluR
- TNF Receptor
- Apoptosis
- Bacterial
- cardiotoxicity
- oxidative stress
- anticancer
- antibiotics
- antimicrobial
- neuroprotective
- anxiolytic
- antidepressant
- anti-stress
- hepatoprotective
- renal protective
- lung protective
- apoptosis
- Inhibitor
- inhibitor
- inhibit