NVP-BBD130
NVP-BBD130 is a potent, stable, ATP-competitive and orally active dual PI3K and mTOR inhibitor. NVP-BBD130 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- CAS. Nr.: 853910-61-9
- Formel: C28H21N5O
- Molecular Weight:443.50
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Biologische Aktivität
PI3K, mTOR[1]
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Cell Line
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Type | Value | Description | References |
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| U-87MG ATCC | EC50 |
13 nM
Compound: 7
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Antiproliferative activity against human U87MG cells
Antiproliferative activity against human U87MG cells
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[PMID: 18248814] |
| U-87MG ATCC | IC50 |
33 nM
Compound: 7
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Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISA
Inhibition of phosphorylation of T308-PKB in human U87MG cells by ELISA
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[PMID: 18248814] |
NVP-BBD130 (1 μM; 72 h) blocks proliferation of melanoma cells, arrests cell cycle at G1 phase in A2058 cells but not C32 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Melanoma cells
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Concentration:1 μM
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Incubation Time:3 days
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Result:Showed a long-term effect on melanoma cell proliferation.
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Cell Line:A2058 and C32 cells
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Concentration:1 μM
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Incubation Time:0, 0.5, 1, 2, 4, 8, 12, 24, 48 and 72 h
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Result:Decreased phosphorylation of PKB/Akt, whereas the phosphorylation status of MAPK was not affected.
Down-regulated the expression of cyclin D1, induced p27Kip1 expression in A2058 cells.
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Cell Line:A2058 cells
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Concentration:1 μM
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Incubation Time:3 days
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Result:Resulted in a complete arrest of most tumor cells in G1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL6 mice, syngeneic B16BL6 mouse melanoma model[1]
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Dosage:40 mg/kg
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Administration:Oral administration, daily for 2 weeks
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Result:Reduced primary tumor size, showed a significant reduction in the size of the cervical lymph node metastasis.
Chemical Information
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CAS. Nr. 853910-61-9
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Molecular Weight 443.50
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Formel C28H21N5O
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SMILES
N#CC(C)(C)C1=CC=C(N2C(N(C)C3=CN=C4C=CC(C#CC5=CC=CN=C5)=CC4=C32)=O)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NVP-BBD130 Related Classifications
HY-150061 Related Classifications
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