OUL232
Based on 2 publication(s) in Google Scholar
OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15. OUL232 is the most potent PARP10 inhibitor described to date (IC50=7.8 nM), as well as the first PARP12 inhibitor ever reported.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.86%
- CAS. Nr.: 943119-42-4
- Formel: C10H10N4O2S
- Molecular Weight:250.28
-
Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biologische Aktivität
-
Chemical Information
-
Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) OUL232
More
Biologische Aktivität
|
PARP7 83 nM (IC50) |
PARP10 7.8 nM (IC50) |
PARP14 300 nM (IC50) |
PARP15 56 nM (IC50) |
PARP1 15 μM (IC50) |
PARP2 10 μM (IC50) |
PARP3 50 μM (IC50) |
PARP4 11 μM (IC50) |
TNKS1 5.4 μM (IC50) |
TNKS2 10 μM (IC50) |
PARP11 240 nM (IC50) |
PARP12 160 nM (IC50) |
PARP16 3.4 μM (IC50) |
OUL232 (compound 27) (1 μM; 10-12 d) saves cells overexpressing PARP10 from ADP ribosylation-dependent cell death[1].
Pharmacokinetic Analysis[1]
| water solubility μg/mL | GI Papp×10-6 cm/s (RM %) | BBB Papp×10-6 cm/s (RM %) | metabolic stablity % | stab in human plasma | stab. in MeOH | stab in PBS pH 7.4 |
| 12.60 | 0.144 | 0.143 | 99.11 | >24 | >24 | >24 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS. Nr. 943119-42-4
-
Appearance Solid
-
Molecular Weight 250.28
-
Formel C10H10N4O2S
-
Color White to pink
-
SMILES
NC1=NN=C2N1C3=C(C(OC)=CC=C3OC)S2
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
-
Journal Impact Factor
-
Most Recent
-
Commun Biol
Screening assay to monitor mono-ADP-ribosylhydrolase activity of viral macrodomains in cells. [Abstract]2026 Mar 12;9(1):386. PMID: 41820535 -
Lösungsmittel & Löslichkeit
DMSO : 33.33 mg/mL (133.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 5 mg/mL (19.98 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.99 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
-
Data Sheet (293 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9955 mL | 19.9776 mL | 39.9553 mL | 99.8881 mL |
| 5 mM | 0.7991 mL | 3.9955 mL | 7.9911 mL | 19.9776 mL | |
| 10 mM | 0.3996 mL | 1.9978 mL | 3.9955 mL | 9.9888 mL | |
| 15 mM | 0.2664 mL | 1.3318 mL | 2.6637 mL | 6.6592 mL | |
| 20 mM | 0.1998 mL | 0.9989 mL | 1.9978 mL | 4.9944 mL | |
| 25 mM | 0.1598 mL | 0.7991 mL | 1.5982 mL | 3.9955 mL | |
| 30 mM | 0.1332 mL | 0.6659 mL | 1.3318 mL | 3.3296 mL | |
| 40 mM | 0.0999 mL | 0.4994 mL | 0.9989 mL | 2.4972 mL | |
| 50 mM | 0.0799 mL | 0.3996 mL | 0.7991 mL | 1.9978 mL | |
| 60 mM | 0.0666 mL | 0.3330 mL | 0.6659 mL | 1.6648 mL | |
| 80 mM | 0.0499 mL | 0.2497 mL | 0.4994 mL | 1.2486 mL | |
| 100 mM | 0.0400 mL | 0.1998 mL | 0.3996 mL | 0.9989 mL |
Powered by Bioz