Art. -Nr.: HY-N4100

Trilobatin

6 Cited Publications

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Based on 6 publication(s) in Google Scholar

Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd, Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. Neuroprotective effects. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells.

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Reinheit: 98.90%
CAS. Nr.: 4192-90-9
Formel: C₂₁H₂₄O₁₀
Molecular Weight:436.41

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Trilobatin Chemical Structure

CAS. Nr.: 4192-90-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (6)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Trilobatin, a natural sweetener derived from Lithocarpus polystachyus Rehd^[1], Trilobatin is an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope^[2]. Neuroprotective effects^[1]. Trilobatin is also a SGLT1/2 inhibitor that selectively induces the proliferation of human hepatoblastoma cells^[3].

IC₅₀ & Target^[2]^[3]

HIV-1

SGLT1

SGLT2

Alle TNF Receptor Isoform-spezifische Produkte anzeigen :

Alle HIV Isoform-spezifische Produkte anzeigen :

Alle SGLT Isoform-spezifische Produkte anzeigen :

SGLT1
SGLT2

In Vitro

Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial reactive oxygen species (mtROS) homeostasis in the first time, which is, at least partly, mediated through the AMPK/Nrf2/Sirt3 signaling pathway^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 4192-90-9
Appearance Solid
Molecular Weight 436.41
Formel C₂₁H₂₄O₁₀
Color White to off-white
SMILES

OC(C=C1)=CC=C1CCC(C2=C(C=C(O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)CO)C=C2O)O)=O
Structure Classification
- Flavonoids
- Dihydrochalcones
- Quinones
- Naphthalene Quinones
Initial Source
- Plants
- Fagaceae
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (6)

All Histological Imaging/StainingELISART-PCRWBIn Vivo Efficacy Study

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Journal Impact Factor

Phytomedicine

Protective effects of E Se tea extracts against alcoholic fatty liver disease induced by high fat/alcohol diet: In vivo biological evaluation and molecular docking study. [Abstract]

2022 Jul:101:154113. PMID: 35490493
Food Chem

Effects of sun drying combined with baking processes on the flavor quality of Chongqing Tuocha raw tea. [Abstract]

2025 Dec 30:497:146992. PMID: 41285060
Food Chem

Flavonoid-mediated metabolic underpinning quality variation in red bud-sport pear mutants. [Abstract]

2025 May 31:489:144992. PMID: 40466530
Ind Crops Prod

2025 Dec 11;239:122458.
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
PLoS One

Trilobatin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice via the NF-κB pathway and alterations in gut microbiota. [Abstract]

2024 Jun 24;19(6):e0305926. PMID: 38913606

Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926. [Abstract]

Representative images of hematoxylin-eosin (HE)-stained colon tissue sections treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).

Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926. [Abstract]

Expression levels of three inflammatory cytokines (TNF-α, IL-1β, and IL-6) in the sera of mice measured by ELISA treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).

Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926. [Abstract]

Expression of mRNA levels of genes encoding tight junction proteins (ZO-1 and occludin) in colon tissue measured by qRT-PCR treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).

Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926. [Abstract]

Protein levels of tight junction proteins (ZO-1 and occludin) in colon tissue measured by western blotting analysis treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).

Trilobatin purchased from MedChemExpress. Usage Cited in: PLoS One. 2024 Jun 24;19(6):e0305926. [Abstract]

Representative images of colon and colon length treated with Trilobatin (TLB) (7.5, 15, 30 μg/g).

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (229.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.2914 mL

11.4571 mL

22.9142 mL

5 mM

0.4583 mL

2.2914 mL

4.5828 mL

10 mM

0.2291 mL

1.1457 mL

2.2914 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (4.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 25 mg/mL (57.29 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Gao J, et al. Trilobatin Protects Against Oxidative Injury in Neuronal PC12 Cells Through Regulating Mitochondrial ROS Homeostasis Mediated by AMPK/Nrf2/Sirt3 Signaling Pathway. Front Mol Neurosci. 2018 Jul 30;11:267. [Content Brief]

[2]. Yin S, et al. Trilobatin as an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. FEBS Lett. 2018 Jul;592(13):2361-2377. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.2914 mL	11.4571 mL	22.9142 mL	57.2856 mL
	5 mM	0.4583 mL	2.2914 mL	4.5828 mL	11.4571 mL
	10 mM	0.2291 mL	1.1457 mL	2.2914 mL	5.7286 mL
	15 mM	0.1528 mL	0.7638 mL	1.5276 mL	3.8190 mL
	20 mM	0.1146 mL	0.5729 mL	1.1457 mL	2.8643 mL
	25 mM	0.0917 mL	0.4583 mL	0.9166 mL	2.2914 mL
	30 mM	0.0764 mL	0.3819 mL	0.7638 mL	1.9095 mL
	40 mM	0.0573 mL	0.2864 mL	0.5729 mL	1.4321 mL
	50 mM	0.0458 mL	0.2291 mL	0.4583 mL	1.1457 mL
	60 mM	0.0382 mL	0.1910 mL	0.3819 mL	0.9548 mL
	80 mM	0.0286 mL	0.1432 mL	0.2864 mL	0.7161 mL
	100 mM	0.0229 mL	0.1146 mL	0.2291 mL	0.5729 mL

Keywords

Trilobatin

6 Cited Publications

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Trilobatin

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Publications Citing Use of MedChemExpress (MCE) Trilobatin

Alle TNF Receptor Isoform-spezifische Produkte anzeigen

Alle HIV Isoform-spezifische Produkte anzeigen

Alle SGLT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (6)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Trilobatin Related Classifications

HY-N4100 Related Classifications