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740 Y-P

(Synonyms: 740YPDGFR; PDGFR 740Y-P)
261 Cited Publications
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Based on 261 publication(s) in Google Scholar

740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone.

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  • Pureté: 99.64%
  • CAS No.: 1236188-16-1
  • Formule: C141H222N43O39PS3
  • Masse moléculaire:3270.70
  • Stockage:

    Sealed storage, away from moisture and light.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • 740 Y-P Chemical Structure
    740 Y-P Chemical Structure
  • Experimental Validation Results for 740 Y-P
  • Experimental Validation Results for 740 Y-P
  • Experimental Validation Results for 740 Y-P
  • Experimental Validation Results for 740 Y-P
  • Experimental Validation Results for 740 Y-P
CAS No.: 1236188-16-1
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  • 740 Y-P Chemical Structure
    740 Y-P Chemical Structure
    1/16
  • 1/16

    740 Y-P purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(13):e2410032. [Abstract]

    Customer Validation
     Protein expression and quantification of SGLT1, GLUT2, p-PI3K, p-AKT, p-S6K1, and p-eIF4B were performed. GAPDH was used to normalize the data. 740Y-P (30 μM; 24 h) was an activator of the PI3K/Akt signaling pathway.

  • 1/16

    740 Y-P purchased from MedChemExpress. Usage Cited in: Theranostics. 2024 Jul 8;14(11):4278-4296. [Abstract]

    Customer Validation
     Western blotting was used to measure p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR expression in MODE-K cells incubated with 740 Y-P (25 μg/mL; 24 h).

  • 1/16

    740 Y-P purchased from MedChemExpress. Usage Cited in: Exp Mol Med. 2023 May;55(5):939-951. [Abstract]

    Customer Validation
     Western blot showing PI3K, AKT, p-AKT, GPX4, ACSL4, TFR1, and SLC7A11 in the tissue samples of ApoE−/− mice infused with saline or Ang II, with or without 740 Y-P (10 mg/kg/d) treatment. n = 3 in each group.

  • 1/16

    740 Y-P purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2020 Jun 30;39(1):123. [Abstract]

    Customer Validation
     Protein expression levels of p-AktSer473, p-mTORSer2448 with or without 740Y-P treatment are measured by Western blotting. Pretreatment with 740Y-P (PI3K agonist) inhibits downregulation of p-AktSer473 and p-mTORSer2448 expression induced by overexpression of BDH2.

  • 1/16

    740 Y-P purchased from MedChemExpress. Usage Cited in: Acta Biomater. 2018 Nov:81:278-292. [Abstract]

    Customer Validation
     PC12 cells are pretreated with 740-YP (30 μM), or SC79 (13.7 μM), or 3BDO (100 μM) for 1 h, and for the duration of GO (50 μg/mL) incubation for 24 h. LC3 turnover is detected by western blotting.

  • 740 Y-P