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Irinotecan

(Synonyms: (+)-Irinotecan; CPT-11; VAL-413free base)
81 Cited Publications
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Based on 81 publication(s) in Google Scholar

Irinotecan ((+)-Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex.

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  • Pureté: 99.97%
  • CAS No.: 97682-44-5
  • Formule: C33H38N4O6
  • Masse moléculaire:586.68
  • Stockage:

    4°C, protect from light

    * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

  • Irinotecan Chemical Structure
    Irinotecan Chemical Structure
  • Experimental Validation Results for Irinotecan
  • Experimental Validation Results for Irinotecan
  • Experimental Validation Results for Irinotecan
  • Experimental Validation Results for Irinotecan
  • Experimental Validation Results for Irinotecan
  • Experimental Validation Results for Irinotecan
  • Experimental Validation Results for Irinotecan
  • Experimental Validation Results for Irinotecan
  • Experimental Validation Results for Irinotecan
  • Experimental Validation Results for Irinotecan
CAS No.: 97682-44-5
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  • Irinotecan Chemical Structure
    Irinotecan Chemical Structure
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    Irinotecan purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 Jun;44(22):1678-1693. [Abstract]

    Customer Validation
     Analysis of drug sensitivity in various SW480 and HCT116 cell lines after 48 h of treatment with with Irinotecan (1 μmol/L).

  • 1/16

    Irinotecan purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 Jun;44(22):1678-1693. [Abstract]

    Customer Validation
     Irinotecan (1 μmol/L, 48 h). Western blotting assays on caspase-3 and cleaved caspase-3 in SW480-Con/CBX3 cells following chemotherapy.

  • 1/16

    Irinotecan purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 Jun;44(22):1678-1693. [Abstract]

    Customer Validation
     Irinotecan (50 mg/kg, twice a week, administered intraperitoneally). Immunohistochemical staining of tumor tissues with antibodies against Ki67, NRF2, and GPX2 (low-power view 100×, high-power view 400×, scale bar = 50 μm).

  • 1/16

    Irinotecan purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 Jun;44(22):1678-1693. [Abstract]

    Customer Validation
     Irinotecan (50 mg/kg, twice a week, administered intraperitoneally). Tumors were measured every two days, and the tumor volumes were calculated. The tumors were excised and weighed 34 days after injection, and representative images of tumors were displayed (bar = 10 mm).

  • 1/16

    Irinotecan purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 Jun;44(22):1678-1693. [Abstract]

    Customer Validation
     SW480-Con/CBX3 cells were treated with Irinotecan (1 μmol/L) for 8 h and stained with C11 BODIPY (oxidized lipid was stained green) and then detected by both flow cytometry and confocal microscopy. ERTracker Blue-White was used to detect the location of lipid oxidation by confocal microscopy (high-power view 400×, scale bar = 50 μm) (N = 3).

  • 1/16

    Irinotecan purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Apr;14(4):1677-1692. [Abstract]

    Customer Validation
     Irinotecan (25 mg/kg/day) were administered intraperitoneally from Day 0 to Day 4. Tumor volume in the control, CPT/5FU and E. copr groups were recorded daily.

  • 1/16

    Irinotecan purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2024 Apr;14(4):1677-1692. [Abstract]

    Customer Validation
     Irinotecan (25 mg/kg/day) were administered intraperitoneally from Day 0 to Day 4. Expression of PCNA was measured by IHC and quantified by ImageJ in the tumor sections. Scale bar: 100 mm.

  • 1/16

    Irinotecan purchased from MedChemExpress. Usage Cited in: J Pharm Pharmacol. 2023 Apr 7;75(4):523-532. [Abstract]

    Customer Validation
     Irinotecan (CPT11; 20 μM; 48 h) or Etoposide (VP16; 20 μM; 48 h) induces MDA-MB-231 cells cycle arrest significantly.

  • 1/16

    Irinotecan purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2021 May 28;6(1):188. [Abstract]

    Customer Validation
     Irinotecan (10 μM; 0–4 days). Cystine promoted colon cancer resistance to oxaliplatin and irinotecan (CPT-11) in vitro.

  • 1/16

    Irinotecan purchased from MedChemExpress. Usage Cited in: Apoptosis. 2016 Feb;21(2):130-42. [Abstract]

    Customer Validation
     (a) CPT-11 induces cell cycle arrest and apoptosis in RAW 264.7macrophages. a.Western blot analysis of cleaved caspase-3 and PARP levels. (b) CPT-11 induced cell cycle arrest and apoptosis in mouse peritoneal macrophages. Western blot analysis of cleaved caspase-3 and PARP levels in peritoneal macrophages isolated from vehicleand CPT-11-administered mice. (c) Caspase-3 inhibitor z-DEVD-fmk (ZD) attenuates CPT-11-induced loss of GATA6+ peritoneal macrophages in mice. Western blot analy

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