MELK
Maternal embryonic leucine zipper kinase
MELK (Maternal embryonic leucine zipper kinase) belongs to the CAMK serine/threonine protein kinase superfamily. Melk is a protein serine/threonine kinase that is maximally active during mitosis. It is involved in diverse functions such as cell cycle, cytokinesis, mRNA splicing and apoptosis. Expression MELK is expressed in cells of various tissue origins. MELK expression is strongly dependant on cell-cycle: MELK is undetectable in cells which have exited cell cycle. The exact function of MELK is currently unknown, however MELK was shown to be involved in cell cycle progression via the protein phosphatase CDC25B phosphorylation, in cytokinesis, in apoptosis via its interaction with the Bcl-2 family of proapoptotic genes and apoptosis signal-regulating kinase (ASK1) and in inhibition of mRNA splicing during mitosis via its association with NIPP1. MELK function is required for mammary tumorigenesis in vivo.
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MELK Produits associés (14)
Produits associés (14)
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Anticorps (1)
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MELK-8a hydrochloride
0 ImagesSynonyms: NVS-MELK8a hydrochlorideMELK-8a hydrochloride (NVS-MELK8a hydrochloride) is an ATP-competitive, selective MELK inhibitor with an IC50 value of 0.002 μM. MELK-8a hydrochloride inhibits NF-κB signaling. MELK-8a hydrochloride induces G2/M checkpoint activation, delayed mitotic entry, G2 phase prolongation, and delayed activation of Aurora A/B and CDK1. MELK-8a hydrochloride inhibits melanoma. MELK-8a hydrochloride can be used for research on triple-negative breast cancer.
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FMF-06-098-1
0 ImagesFMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1.
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MELK-8a
0 ImagesSynonyms: NVS-MELK8aMELK-8a (NVS-MELK8a) is an ATP-competitive, selective MELK inhibitor with an IC50 value of 0.002 μM. MELK-8a inhibits NF-κB signaling. MELK-8a induces G2/M checkpoint activation, delayed mitotic entry, G2 phase prolongation, and delayed activation of Aurora A/B and CDK1. MELK-8a inhibits melanoma. MELK-8a can be used for research on triple-negative breast cancer.
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JNJ-47117096 hydrochloride
0 ImagesSynonyms: MELK-T1 hydrochloride
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Moracin G
0 ImagesCat. No.: HY-N17632CAS No.: 73338-86-0Moracin G is a plant-derived kinase modulator and receptor ligand that forms stable bindings with multiple key proteins (AKT1, COX2 and Estrogen receptor 1) and competitively inhibits the activity of specific kinases. By binding to MELK to disrupt cell cycle regulation, Moracin G impairs the survival and proliferation of cancer cells, induces cancer cell apoptosis, and thereby exerts anti-tumor potential. Moracin G can be used in research related to periodontitis and breast cancer.
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MELK-8a hydrochloride (Standard)
0 ImagesCat. No.: HY-100368ARCAS No.: 2096992-20-8Synonyms: NVS-MELK8a hydrochloride (Standard)MELK-8a hydrochloride (Standard) (NVS-MELK8a hydrochloride (Standard)) is the analytical standard of MELK-8a hydrochloride (HY-100368A). This product is intended for research and analytical applications. MELK-8a hydrochloride (NVS-MELK8a hydrochloride) is an ATP-competitive, selective MELK inhibitor with an IC50 value of 0.002 μM. MELK-8a hydrochloride inhibits NF-κB signaling. MELK-8a hydrochloride induces G2/M checkpoint activation, delayed mitotic entry, G2 phase prolongation, and delayed activation of Aurora A/B and CDK1. MELK-8a hydrochloride inhibits melanoma. MELK-8a hydrochloride can be used for research on triple-negative breast cancer.
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JNJ-47117096
0 ImagesCat. No.: HY-12420ACAS No.: 1610586-62-3
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