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Z-VAD(OMe)-FMK

(Synonyms: Z-Val-Ala-Asp(OMe)-FMK)
207 Cited Publications
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Based on 207 publication(s) in Google Scholar

Z-VAD(OMe)-FMK (Z-Val-Ala-Asp(OMe)-FMK) is a cell-permeable and irreversible pan-caspase inhibitor. Z-VAD(OMe)-FMK is an ubiquitin carboxy-terminal hydrolase L1 (UCHL1) inhibitor. Z-VAD(OMe)-FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1.

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  • Pureté: 98.0%
  • CAS No.: 187389-52-2
  • Formule: C22H30FN3O7
  • Masse moléculaire:467.49
  • Stockage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • Z-VAD(OMe)-FMK Chemical Structure
    Z-VAD(OMe)-FMK Chemical Structure
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
  • Experimental Validation Results for Z-VAD(OMe)-FMK
CAS No.: 187389-52-2
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  • Z-VAD(OMe)-FMK Chemical Structure
    Z-VAD(OMe)-FMK Chemical Structure
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    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: J Biol Chem. 2019 May 17;294(20):8161-8170. [Abstract]

    Customer Validation
     HeLa cells are pretreated with or without the indicated concentrations of Z-VAD-FMK for 1 h before treatment with 3 μM T007-1 for 12, 24, or 48 h. Protein levels of cleaved PARP and caspase-3 are detected via western blot using GAPDH as a loading control.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Cell. 2018 Sep 6;174(6):1477-1491.e19. [Abstract]

    Customer Validation
     WT and Tbk1-/-MEFs are pre-incubated with 20 μM zVAD-fmk in the presence or absence of Nec-1 s for 0.5 h and then stimulated with mTNFa for indicated periods of time. Complex II is isolated by anti-FADD immunoprecipitation and RIPK1 binding is revealed by immunoblotting.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Jan 18;9(2):27. [Abstract]

    Customer Validation
     Overexpression PCDHGA9 induces GC cell apoptosis, cell cycle arrest, and autophagy. Western blot analysis determines that 10 μg/mL V-ZAD-FMK inhibits the activation of caspases.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Chem Res Toxicol. 2018 Dec 17;31(12):1418-1425. [Abstract]

    Customer Validation
     HUVEC cells are stimulated with TCBQ for 6 h, pre-treated with either 10 μM Z-VADFMK (pan-caspase inhibitor) or 10 μM AC-YVAD-CHO (caspase 1/4/5 inhibitor) for 1 h. Then caspase 1/4/5 and GSDMD expressions are detected by Western blotting analysis.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: J Immunol. 2018 Jan 1;200(1):271-285. [Abstract]

    Customer Validation
     RelA+/+ and RelA-/- MEFs are treated with TNF (20 ng/mL)/Smac Mimetics (10 nM) or TNF (20 ng/mL)/Smac Mimetics (10 nM)/Z-VAD (20 μM) at the indicated hours. Cell lysates are collected and subjected to western blot analysis using the indicated antibody.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: PLoS One. 2018 Aug 6;13(8):e0201920. [Abstract]

    Customer Validation
     The pretreatment of Z-VAD-FMK significantly reduces the levels of cleaved caspase-3 and cleaved PARP. The pretreatment of 3-MA blocks the conversion of LC3-I to LC3-II.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2018;46(5):1779-1792. [Abstract]

    Customer Validation
     Western blot and quantitative analysis of the expressions of ZO-1, Claudin-1, and Occludin. Apoptosis inhibitor Z-VAD(OMe)-FMK is used.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Onco Targets Ther. 2018 Feb 26:11:1025-1035. [Abstract]

    Customer Validation
     Reversine inhibits the expression levels of Cyclin A2, Cyclin B1, and p-Rb, but promotes p21 expression.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2017 May 1:393:22-32. [Abstract]

    Customer Validation
     Effects of p38 MAPK inhibitor (SB203580), ERK inhibitor (U0126), JNK inhibitor (SP600125), caspase inhibitor (Z-VAD-FMK) and NAC on SGC-7901 and MGC-803 treated with DOX/VCPA combination treatment. VCPA pretreatment strategy is the same as above. SB203580 (20 μM), U0126 (10 μM), SP600125 (20 μM), Z-VAD-FMK (10 μM) and NAC (5 mM) are treated 2 h before DOX (2 μg/mL) added into the culture, respectively. MAPK pathway protein levels are determined.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Sci Rep. 2017 Jun 7;7(1):2929. [Abstract]

    Customer Validation
     Caspase signaling pathway. MCF7 and MDA-MB-231 cells are pretreated with 10 µM Z-VAD-FMK and BOC-D-FMK for 1 h and then exposed to 80 μM ω3-FFAs and 20 μM ATRA for 48 h. The expression of PARP protein.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2017 Jun:90:446-454. [Abstract]

    Customer Validation
     Caspase-8, Caspase-9, Caspase-3 and PARP cleavage levels are calculated by western blotting analysis in PC-3 cells treated under various conditions as indicated for 24 h. After ZVAD combination treatment, CHI-induced high expression of cleaved Caspase-8, Caspase-9, Caspase-3 and PARP is impeded dramatically.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Elife. 2017 Dec 12;6:e30590. [Abstract]

    Customer Validation
     Cultured S2 cells are treated with DMSO or z-VAD-FMK as indicated, and then mock infected for 24 hr or infected with DCV (MOI=5) for indicated time.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Sci Rep. 2016 Dec 1;6:38267. [Abstract]

    Customer Validation
     SHK-induced splicing events that occurred in PARP, Caspase 8, 9 and 3 are also blocked by ZVAD-FMK. SHK-induced apoptosis is caspase-dependent in SGC-7901 gastric cancer cells. Detection of apoptosis-related protein PARP and caspase-3, -8, -9. GAPDH is used as a loading control.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Oncotarget. 2016 Dec 20;7(51):84810-84825. [Abstract]

    Customer Validation
     Effect of proteasome or caspase inhibition on BCR/Abl protein suppression under oxygen or glucose shortage.K562 cells are incubated at 0.1% O2 in standard medium (top panels) or 21% O2 in the absence of glucose (bottom panels) for the indicated times, treated with the pan-caspase inhibitor z-VAD-fmk (50 μM) for the indicated times and lysed. BCR/Abl protein expression is determined by Western blotting using α-Tubulin as loading control.

  • 1/16

    Z-VAD(OMe)-FMK purchased from MedChemExpress. Usage Cited in: Chinese Journal of Cell Biology. 2016, 38(10): 1232-1243.

    Customer Validation
     TNFα induces activation of caspase signaling pathway in L929-A cells but not L929-N cells.

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