Ac-DEVD-CHO TFA
Based on 47 publication(s) in Google Scholar
Ac-DEVD-CHO TFA is a peptide inhibitor of caspase-3 (Ki=230 pM) and caspase-7. Ac-DEVD-CHO TFA reduces caspase-3 activity and apoptosis induced by Prostaglandin E2 (HY-101952) in rat cortical neurons. Ac-DEVD-CHO TFA is promising for research of neurodegenerative diseases and cancers.
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- Formule: C22H31F3N4O13
- Masse moléculaire:616.50
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Ac-DEVD-CHO TFA
More- Cell. 2025 May 29;188(11):3013-3029.e19. [Abstract]
- Adv Mater. 2023 Jun;35(23):e2300548. [Abstract]
- Redox Biol. 2024 Jun 8:74:103225. [Abstract]
- Sci Adv. 2025 May 16;11(20):eadq3870. [Abstract]
- Biomaterials. 2022 Sep 29;290:121832. [Abstract]
- J Control Release. 2021 Jun 10:334:21-33. [Abstract]
- Cell Death Dis. 2025 Jan 26;16(1):44. [Abstract]
- Cell Death Dis. 2022 Aug 18;13(8):721. [Abstract]
- Cancer Lett. 2021 Nov 1:520:143-159. [Abstract]
- J Immunother Cancer. 2024 Mar 1;12(3):e008054. [Abstract]
- Cell Death Discov. 2024 Mar 8;10(1):122. [Abstract]
- J Colloid Interface Sci. 2022 Jan 15;606(Pt 2):1950-1965. [Abstract]
- Diabetes. 2022 Apr 1;71(4):637-652. [Abstract]
- Basic Res Cardiol. 2021 Jan 23;116(1):3. [Abstract]
- Apoptosis. 2019 Oct;24(9-10):703-717. [Abstract]
- Apoptosis. 2019 Apr;24(3-4):312-325. [Abstract]
- Int J Biol Macromol. 2025 Sep 4;327(Pt 2):147256. [Abstract]
- Int J Biol Macromol. 2025 May;306(Pt 3):141587. [Abstract]
- Int J Mol Med. 2024 Nov;54(5):96. [Abstract]
- Cell Rep. 2025 Sep 12;44(9):116286. [Abstract]
- Cell Prolif. 2019 Sep;52(5):e12663. [Abstract]
- Appl Mater Today. 2021, 101066.
- Eur J Med Chem. 2025 May 5:289:117485. [Abstract]
- J Agric Food Chem. 2023 Oct 18;71(41):15287-15295. [Abstract]
- J Agric Food Chem. 2019 Oct 23;67(42):11718-11727. [Abstract]
- Biochem Pharmacol. 2021 Jun:188:114538. [Abstract]
- Toxicology. 2024 Aug 6:153906. [Abstract]
- Chem Biol Interact. 2021 Dec 1:350:109704. [Abstract]
- Sci Rep. 2025 Apr 18;15(1):13377. [Abstract]
- Sci Rep. 2025 Jan 11;15(1):1654. [Abstract]
- Exp Neurol. 2025 Nov:393:115371. [Abstract]
- Acta Biochim Biophys Sin (Shanghai). 2022 Jan 25;54(1):64-76. [Abstract]
- J Virol. 2026 May 19;100(5):e0011726. [Abstract]
- Toxicol Appl Pharmacol. 2025 Dec 8:507:117682. [Abstract]
- Arch Pharm (Weinheim). 2025 Jul;358(7):e70031. [Abstract]
- Cell Biol Int. 2020 Apr;44(4):937-946. [Abstract]
- Biochimie. 2019 Dec;167:217-227. [Abstract]
- Vet Microbiol. 2021 Oct:261:109177. [Abstract]
- PLoS One. 2019 Dec 30;14(12):e0227278. [Abstract]
- Curr Protoc. 2026 Jan;6(1):e70288. [Abstract]
- Genet Mol Biol. 2024 Mar 4;47(1):e20220170. [Abstract]
- Biosci Biotechnol Biochem. 2020 May;84(5):989-996. [Abstract]
- J Tradit Chinese Medical Sci. 2024 Jun 5.
- Research Square Preprint. 2024 Apr 12.
- SSRN. 2023 Nov 8.
- Research Square Preprint. 2023 Oct 23.
- Universitat Politècnica de València. 2020 Sep 7.
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Voir tous les produits spécifiques à Isoform Caspase
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Activité biologique
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Caspase-3 230 pM (Ki) |
Caspase-7 |
Chemical Information
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Masse moléculaire 616.50
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Formule C22H31F3N4O13
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SMILES
FC(C(O)=O)(F)F.O=C(N[C@@H](C(C)C)C(N[C@H](C=O)CC(O)=O)=O)[C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (47)
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Journal Impact Factor
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Most Recent
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Cell
2025 May 29;188(11):3013-3029.e19. PMID: 40252640 -
Adv Mater
Impairing Tumor Metabolic Plasticity via a Stable Metal-Phenolic-Based Polymeric Nanomedicine to Suppress Colorectal Cancer. [Abstract]2023 Jun;35(23):e2300548. PMID: 36917817 -
Redox Biol
FAM3A plays a key role in protecting against tubular cell pyroptosis and acute kidney injury. [Abstract]2024 Jun 8:74:103225. PMID: 38875957 -
Sci Adv
Endogenous/exogenous dual-responsive nanozyme for photothermally enhanced ferroptosis-immune reciprocal synergistic tumor therapy. [Abstract]2025 May 16;11(20):eadq3870. PMID: 40367177
Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: Sci Adv. 2025 May 16;11(20):eadq3870. [Abstract]
Ac-DEVD-CHO (DEVD) (50 μM) rescued 4T1 cells from MCMSFT-induced cell death.
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Biomaterials
Oxygen-boosted biomimetic nanoplatform for synergetic phototherapy/ferroptosis activation and reversal of immune-suppressed tumor microenvironment. [Abstract]2022 Sep 29;290:121832. PMID: 36228518 -
J Control Release
Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy. [Abstract]2021 Jun 10:334:21-33. PMID: 33872626 -
Cell Death Dis
ZBP1-mediated PANoptosis is a crucial lethal form in diverse keratinocyte death modalities in UVB-induced skin injury. [Abstract]2025 Jan 26;16(1):44. PMID: 39863598 -
Cell Death Dis
Whole transcriptome and proteome analyses identify potential targets and mechanisms underlying tumor treating fields against glioblastoma. [Abstract]2022 Aug 18;13(8):721. PMID: 35982032 -
Cancer Lett
Photodynamic therapy induces human esophageal carcinoma cell pyroptosis by targeting the PKM2/caspase-8/caspase-3/GSDME axis. [Abstract]2021 Nov 1:520:143-159. PMID: 34256094
Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2021 Nov 1:520:143-159. [Abstract]
Ac-DEVD-CHO (DEVD) (10 mM) decreased the pyroptosis ratio and the formation of pyroptotic-like cells in Eca109 and Ec9706 cells.
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J Immunother Cancer
Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer. [Abstract]2024 Mar 1;12(3):e008054. PMID: 38429070
Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Mar 1;12(3):e008054. [Abstract]
Ac-DEVD-CHO (100 µM; 4 h), a specific inhibitor of CASP3, prevented the activation of CASP3 and inhibited the cleavage of GSDME in CT26 and HCT116 cells on IR700DX-6T-PDT.
Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Mar 1;12(3):e008054. [Abstract]
Ac-DEVD-CHO (100 µM; 4 h), a specific inhibitor of CASP3, attenuated the release of LDH in CT26 and HCT116 cells on IR700DX-6T-PDT.
Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2024 Mar 1;12(3):e008054. [Abstract]
Ac-DEVD-CHO (100 µM; 4 h) markedly reduced the number of swollen pyroptotic cells in CT26 and HCT116 cells on IR700DX-6T-PDT. Red arrows represent pyroptotic cells.
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Cell Death Discov
2024 Mar 8;10(1):122. PMID: 38458999 -
J Colloid Interface Sci
Reactive oxygen species / photothermal therapy dual-triggered biomimetic gold nanocages nanoplatform for combination cancer therapy via ferroptosis and tumor-associated macrophage repolarization mechanism. [Abstract]2022 Jan 15;606(Pt 2):1950-1965. PMID: 34695762 -
Diabetes
Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue. [Abstract]2022 Apr 1;71(4):637-652. PMID: 35044451 -
Basic Res Cardiol
Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1. [Abstract]2021 Jan 23;116(1):3. PMID: 33484341 -
Apoptosis
ATP induces caspase-3/gasdermin E-mediated pyroptosis in NLRP3 pathway-blocked murine macrophages. [Abstract]2019 Oct;24(9-10):703-717. PMID: 31175486
Ac-DEVD-CHO TFA purchased from MedChemExpress. Usage Cited in: Apoptosis. 2019 Oct;24(9-10):703-717. [Abstract]
BMDMs were first primed with LPS (500 ng/ml) for 4 h, pre-treated with or without MCC950 (1 μM) and caspase-3 inhibitor Ac-DEVD-CHO (DEVD) for 1 h and followed by stimulation with ATP (5 mM) in the presence or absence of MCC950. The cell lysates are collected and western blotting is performed to assess the expression levels of indicated proteins.
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Apoptosis
Chemotherapeutic paclitaxel and cisplatin differentially induce pyroptosis in A549 lung cancer cells via caspase-3/GSDME activation. [Abstract]2019 Apr;24(3-4):312-325. PMID: 30710195 -
Int J Biol Macromol
Pleurotus citrinopileatus polysaccharides ameliorate DSS-induced ulcerative colitis by improving intestinal barrier and inflammation modulation via NF-κB pathway. [Abstract]2025 Sep 4;327(Pt 2):147256. PMID: 40914366 -
Int J Biol Macromol
Z-VAD(OMe)-FMK suppresses Seneca Valley Virus replication by targeting the active sites of the 3C protease. [Abstract]2025 May;306(Pt 3):141587. PMID: 40032110 -
Int J Mol Med
TREM2, a critical activator of pyroptosis, mediates the anti‑tumor effects of piceatannol in uveal melanoma cells via caspase 3/GSDME pathway. [Abstract]2024 Nov;54(5):96. PMID: 39219277 -
Cell Rep
Pathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation. [Abstract]2025 Sep 12;44(9):116286. PMID: 40944911 -
Cell Prolif
Caspase-3-mediated GSDME activation contributes to cisplatin- and doxorubicin-induced secondary necrosis in mouse macrophages. [Abstract]2019 Sep;52(5):e12663. PMID: 31347748 -
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Eur J Med Chem
Exosome/liposome hybrid nanovesicles for enhanced phototherapy and boosted anti-tumor immunity against melanoma. [Abstract]2025 May 5:289:117485. PMID: 40081104 -
J Agric Food Chem
2023 Oct 18;71(41):15287-15295. PMID: 37788342 -
J Agric Food Chem
2019 Oct 23;67(42):11718-11727. PMID: 31518118 -
Biochem Pharmacol
Homoharringtonine synergizes with quizartinib in FLT3-ITD acute myeloid leukemia by targeting FLT3-AKT-c-Myc pathway. [Abstract]2021 Jun:188:114538. PMID: 33831397 -
Toxicology
Proteasome inhibition induces apoptosis through simultaneous inactivation of MCL-1/BCL-XL by NOXA independent of CHOP and JNK pathways. [Abstract]2024 Aug 6:153906. PMID: 39117261 -
Chem Biol Interact
Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma. [Abstract]2021 Dec 1:350:109704. PMID: 34655567 -
Sci Rep
Caerin 1.1 and 1.9 peptides induce acute caspase 3/GSDME-mediated pyroptosis in epithelial cancer cells. [Abstract]2025 Apr 18;15(1):13377. PMID: 40251208 -
Sci Rep
RSL3 induces ferroptosis by activating the NF-κB signalling pathway to enhance the chemosensitivity of triple-negative breast cancer cells to paclitaxel. [Abstract]2025 Jan 11;15(1):1654. PMID: 39794456 -
Exp Neurol
KIF23 inhibition protects against perioperative neurocognitive disorders by hindering ROS/caspase-3/GSDME-mediated pyroptosis. [Abstract]2025 Nov:393:115371. PMID: 40639436 -
Acta Biochim Biophys Sin (Shanghai)
Induction of multiple subroutines of regulated necrosis in murine macrophages by natural BH3-mimetic gossypol. [Abstract]2022 Jan 25;54(1):64-76. PMID: 35130622 -
J Virol
Febrifugine dihydrochloride restricts porcine epidemic diarrhea virus replication by modulating the IGF1R-driven PI3K/AKT-apoptosis axis. [Abstract]2026 May 19;100(5):e0011726. PMID: 41983768 -
Toxicol Appl Pharmacol
2025 Dec 8:507:117682. PMID: 41371369 -
Arch Pharm (Weinheim)
2025 Jul;358(7):e70031. PMID: 40702793 -
Cell Biol Int
DJ-1 inhibits autophagy activity of prostate cancer cells by repressing JNK-Bcl2-Beclin1 signaling. [Abstract]2020 Apr;44(4):937-946. PMID: 31868268 -
Biochimie
Autophagy mediated by JNK1 resists apoptosis through TRAF3 degradation in osteoclastogenesis. [Abstract]2019 Dec;167:217-227. PMID: 31654668 -
Vet Microbiol
Lipid metabolism is a novel and practical source of potential targets for antiviral discovery against porcine parvovirus. [Abstract]2021 Oct:261:109177. PMID: 34391196 -
PLoS One
2019 Dec 30;14(12):e0227278. PMID: 31887216 -
Curr Protoc
Overcoming Low-Field Limitations: High-Quality Ex Vivo Soft Tissue Imaging with Compact MRI Systems. [Abstract]2026 Jan;6(1):e70288. PMID: 41481274 -
Genet Mol Biol
The inhibition of Beclin1-dependent autophagy sensitizes PTC cells to ABT737-induced death. [Abstract]2024 Mar 4;47(1):e20220170. PMID: 38488525 -
Biosci Biotechnol Biochem
Autophagy promotion enhances the protective effect of Morroniside on human OA chondrocyte. [Abstract]2020 May;84(5):989-996. PMID: 31983285 -
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Pureté et documentation
Références
[1]. Takadera T, et al. Prostaglandin E(2) induces caspase-dependent apoptosis in rat cortical cells. Neurosci Lett. 2002 Jan 11;317(2):61-4. [Content Brief]
[2]. Garcia-Calvo M, et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem. 1998 Dec 4;273(49):32608-13. [Content Brief]
Calculators
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Ac-DEVD-CHO TFA Related Classifications
HY-P1001A Related Classifications
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