FT108
FT108 is a selective HDAC6 inhibitor with an IC50 of 0.026 μM. FT108 exhibits only modest in vitro activity against HDAC3 and HDAC8 with IC50 values of 6.68 and 4.07 μM. FT108 increases acetylation of tubulin and has little to no effect on acetylated histone H3 levels. FT108 lacks activity against myeloproliferative neoplasm cell lines, and does not suppress JAK2 phosphorylation or its downstream targets pSTAT3 and pSTAT5.
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- CAS No.: 2379645-28-8
- Formule: C16H20N2O5
- Masse moléculaire:320.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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HDAC6 0.026 μM (IC50) |
HDAC8 4.07 μM (IC50) |
HDAC3 6.68 μM (IC50) |
FT108 (0.03-16 μM; 48 h) does not reduce survival of HEL92.1.7, SET-2, JAK2V617F Ba/F3, or MPLW515L Ba/F3 MPN cell lines when treated for 48 hours at concentrations up to 16 μM[1].
FT108 (0.2-1 μM; 24 h) increases ac-tubulin levles but does not alter JAK-STAT signaling pathway activity or acetylated histone H3 levels[1].
FT108 is a highly selective inhibitor of HDAC6 (IC50 = 0.026 μM) with weak cross-reactivity to HDAC3 (IC50 = 6.68 μM) and HDAC8 (IC50 = 4.07 μM) in enzymatic biochemical assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human HEL92.1.7, human SET-2, mouse JAK2V617 Ba/F3, mouse MPLW515LBa/F3 cells
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Concentration:0.03, 0.06, 0.12, 0.25, 1, 2, 4, 8,16 μM
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Incubation Time:48 h
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Result:Lacked activity in all tested MPN cell lines, with cell survival remaining near 100% across all concentrations tested.
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Cell Line:human HEL92.1.7 MPN cells
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Concentration:0.2, 0.5, 1 μM
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Incubation Time:24 h
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Result:Caused marked increases in ac-tubulin levels, consistent with effective HDAC6 suppression.
Had little to no effect on acetylated histone H3 levels.
Did not reduce levels of phosphorylated JAK2, phosphorylated STAT3, or phosphorylated STAT5, and had no impact on total JAK2, STAT3, or STAT5 levels.
Chemical Information
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CAS No. 2379645-28-8
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Masse moléculaire 320.34
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Formule C16H20N2O5
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SMILES
O=C(C1=CC=C2C(OCCN(C2)C(C3CCOCC3)=O)=C1)NO
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FT108 Related Classifications
HY-182720 Related Classifications
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