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Cat. No.: HY-P3361

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IDR-1018

IDR-1018 is an innate defense regulator conjugate, with MICs of 16 μg/mL for MRSA USA300 LAC, MRSA SAP 0017 and S. epidermidis ATCC14990. IDR-1018 can be used to synthesis V-IDR1018 (vancomycin-innate defense regulator conjugate).

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CAS No.: 1453221-07-2
Formule: C₇₁H₁₂₆N₂₆O₁₂
Masse moléculaire:1535.93

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IDR-1018 Chemical Structure

CAS No.: 1453221-07-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
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Classifications
Bioz

Activité biologique

Description

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In Vitro

IDR-1018 modulates the expression of neutrophil adhesion and activation markers^[3].
IDR-1018 is the most potent inducer of chemokines to date and demonstrates anti-infective and anti-inflammatory activity in mouse models, including efficacy in treating Plasmodium berghei ANKA cerebral malaria when administered in conjunction with standard first-line antimalarials^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1453221-07-2
Masse moléculaire 1535.93
Formule C₇₁H₁₂₆N₂₆O₁₂
Sequence

Val-Arg-Leu-Ile-Val-Ala-Val-Arg-Ile-Trp-Arg-Arg-NH2
Sequence Shortening

VRLIVAVRIWRR-NH2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hashem Etayash, Multifunctional Antibiotic–Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response. J. Med. Chem. 2021, 64, 22, 16854-16863.

[2]. Hashem Etayash, et al. Correction to “Multifunctional Antibiotic–Host Defense Peptide Conjugate Kills Bacteria, Eradicates Biofilms, and Modulates the Innate Immune Response”. J. Med. Chem. 2022, 65, 3, 2710-2711.

[3]. François Niyonsaba, et al. The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions. J Leukoc Biol. 2013 Jul;94(1):159-70. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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IDR-1018

Voir tous les produits spécifiques à Isoform Parasite

Voir tous les produits spécifiques à Isoform Antibiotic

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

IDR-1018 Related Classifications

HY-P3361 Related Classifications