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Oligomycin

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Oligomycin, an antifungal antibiotic, is an inhibitor of H+-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells.

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  • Oligomycin Chemical Structure
    Oligomycin Chemical Structure
  • Experimental Validation Results for Oligomycin
  • Experimental Validation Results for Oligomycin
  • Experimental Validation Results for Oligomycin
  • Experimental Validation Results for Oligomycin
  • Experimental Validation Results for Oligomycin
CAS No.: 1404-19-9
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  • Oligomycin Chemical Structure
    Oligomycin Chemical Structure
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    Oligomycin purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr 13:e2413376. [Abstract]

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     Fluorescence images of cellular ROS levels: NanoMassage ameliorate ROS generation and cell apoptosis induced by CCCP or Oligomycin (10 μM, 1 h) in neuron-like cells.

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    Oligomycin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Jan 2:S2090-1232(24)00623-4. [Abstract]

    Customer Validation
     Real-time analysis of the OCR was carried out with a Seahorse analyser with single cells from mice liver tissues following treatment with Oligomycin (1.5 μM).

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    Oligomycin purchased from MedChemExpress. Usage Cited in: Cell. 2024 Apr 25;187(9):2269-2287.e16. [Abstract]

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     Abundance of BRCA2, γH2AX protein, and MG-H1 adduct formation in HeLa Kyoto cells after treatment with Oligomycin (1 μM) for 4, 24, and 48 h.

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    Oligomycin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Oct 8;15(1):8723. [Abstract]

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     qRT-PCR analysis of Chop and Asns mRNA levels in seven-month-old C57BL/6J male and female mice treated with DMSO or Oligomycin (0.5 mg/kg, ip).

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    Oligomycin purchased from MedChemExpress. Usage Cited in: J Am Chem Soc. 2023 Oct 18;145(41):22433-22441. [Abstract]

    Customer Validation
     Typical curves showing temperature fluctuations of individual cells at different time intervals in the absence of stimulus (black) and after the addition of Oligomycin (blue) (100 μM).

  • Oligomycin