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Cat. No.: HY-120115

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PARPi-FL

(Synonyms: Olaparib-bodipy FL)

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PARPi-FL (Olaparib-bodipy FL) is a small-molecule fluorescent inhibitor of PARP1 that can specifically bind to PARP1. PARPi-FL can be used as a fluorescent imaging agent for tumor detection, diagnosis, and surgical guidance.

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Pureté: 99.77%
CAS No.: 1380359-84-1
Formule: C₃₄H₃₂BF₃N₆O₃
Masse moléculaire:640.46

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

PARPi-FL Chemical Structure

CAS No.: 1380359-84-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Voir tous les produits spécifiques à Isoform PARP :

In Vitro

PARPi-FL (0.33-100 μM; 7 days) has IC₅₀ values of 23.8 and 5.5 μM for U87 and U251, respectively^[2]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetic Analysis in mice^[2]

EC₅₀	Abs_max/Em_max	CHI	logP_CHI	protein binding
12.2 nM	507 nM/525 nM	72.21	2.9	99.2%

PARPi-FL (2.5 mg/kg; intravenous injection; single dose) shows significantly higher retention levels and duration in tumor tissues than in healthy brain and muscle tissues in a mouse glioma xenograft model^[2].
PARPi-FL (75 nmol; intravenous injection; single dose) enables high-contrast imaging of tumors in a mouse model of oral squamous cell carcinoma, and the signal is specific to PARP1 expression^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1380359-84-1
Appearance Solid
Masse moléculaire 640.46
Formule C₃₄H₃₂BF₃N₆O₃
Color Yellow to orange
SMILES

O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCC4=CC=C5C=C6C(C)=CC(C)=[N]6[B+3]([F-])([N-]54)[F-])=O)=O)=C2)F)C7=C1C=CC=C7
Synonyms

Olaparib-bodipy FL
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 50 mg/mL (78.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5614 mL

7.8069 mL

15.6138 mL

5 mM

0.3123 mL

1.5614 mL

3.1228 mL

10 mM

0.1561 mL

0.7807 mL

1.5614 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (275 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ziadeh T, et al. Poly(ADP-ribose) polymerase inhibitors in prostate cancer: a cornerstone in precision oncology. Pharmacogenomics. 2021 Dec;22(18):1237-1250. [Content Brief]

[2]. Irwin CP, et al. PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014 May;16(5):432-40. doi: 10.1016/j.neo.2014.05.005. Epub 2014 Jun 23. [Content Brief]

[3]. Susanne Kossatz, et al.Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. Sci Rep. 2016; 6: 21371.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.5614 mL	7.8069 mL	15.6138 mL	39.0344 mL
	5 mM	0.3123 mL	1.5614 mL	3.1228 mL	7.8069 mL
	10 mM	0.1561 mL	0.7807 mL	1.5614 mL	3.9034 mL
	15 mM	0.1041 mL	0.5205 mL	1.0409 mL	2.6023 mL
	20 mM	0.0781 mL	0.3903 mL	0.7807 mL	1.9517 mL
	25 mM	0.0625 mL	0.3123 mL	0.6246 mL	1.5614 mL
	30 mM	0.0520 mL	0.2602 mL	0.5205 mL	1.3011 mL
	40 mM	0.0390 mL	0.1952 mL	0.3903 mL	0.9759 mL
	50 mM	0.0312 mL	0.1561 mL	0.3123 mL	0.7807 mL
	60 mM	0.0260 mL	0.1301 mL	0.2602 mL	0.6506 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

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PARPi-FL

Voir tous les produits spécifiques à Isoform PARP

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

PARPi-FL Related Classifications

HY-120115 Related Classifications