Cat. No.: HY-178211

SHY-867

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SHY-867 is a pan RAS inhibitor. SHY-867 effectively prevents the binding of K-Ras proteins and other members of the Ras superfamily of small GTPases with EC₅₀ values of 0.5-3 μM. SHY-867 effectively inhibits the phosphorylation of MEK, ERK1/2, and AKT downstream of K-Ras. SHY-867 inhibits the formation of the Ras-GTP activity complex. SHY-867 can be used to the studies of pancreatic cancer and non-small cell lung cancer.

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Pureté: 99.66%
CAS No.: 2446484-96-2
Formule: C₂₆H₂₇N₇OS
Masse moléculaire:485.60

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

SHY-867 Chemical Structure

CAS No.: 2446484-96-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

K-Ras WT

2 μM (IC₅₀)

KRas G12D

2.5 μM (IC₅₀)

KRas G12C

1.2 μM (IC₅₀)

KRas Q61H

3 μM (IC₅₀)

MEK

ERK1

ERK2

Akt

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In Vitro

SHY-867 competes with GTP binding to K-Ras WT, the G12D, G12C, and Q61H mutants, as well as Rac-1, Rho-A, Rab5, and Rab35 with IC₅₀s of 2, 2.5, 1.2, 3, 2.5, 3, 0.5 and 0.75 μM^[1].
SHY-867 (0.1-1 μM, 72 h) exhibits potent antiproliferative effects in multiple tumor cell lines, including pancreatic cancer (PANC-1, MIA PaCa-2, BxPC3) and non-small cell lung cancer (NCI-H1975, A549, NCI-H1299), with IC₅₀ values ranging from 0.3-1 μM^[1].
SHY-867 (0.3-10 μM, 6 h) significantly inhibits the phosphorylation of key signaling molecules induced by EGF in PANC-1, MIA PaCa-2 and NCI-H1975 cells^[1].
SHY-867 (1.25-10 μM, 6 h) inhibits Ras-GTP complex formation with an IC₅₀ of 1-3 μM in PANC-1, MIA PaCa-2 and NCI-H1975 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

PANC-1, MIA PaCa-2 and NCI-H1975 cells
Concentration:

0.3, 0.6, 1.25, 2.5, 5 and 10 μM
Incubation Time:

6 h
Result:

Exhibited IC₅₀s on the phosphorylation of MEK and Erk1/2 were approximately 1 μM in PANC-1 and MIA PaCa-2 and 5 μM in NCI-H1975.
Exhibited IC₅₀s of approximately 7 μM in PANC-1 and MIA PaCa-2 and 10 μM in NCI-H1975 for Akt.
Prevented Ras-GTP complex formation with IC₅₀ values in the range of 1 to 3 μM.

Chemical Information

CAS No. 2446484-96-2
Appearance Solid
Masse moléculaire 485.60
Formule C₂₆H₂₇N₇OS
Color Off-white to light yellow
SMILES

CO[C@H]1CC[C@H](C1)NC2=NC(C3=NC=CN3C)=NC4=C2C(C5=CC=CC=C5)=C(S4)C6=NN(C=C6)C
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Carta L, et al. Identification of Small-Molecule Inhibitors that Block the GTP-Binding Pocket of K-Ras and Other Members of the Ras Superfamily of Small GTPases. Mol Cancer Ther. 2025 Sep 12:OF1-OF10. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SHY-867

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

MAPK Compound Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Reprogramming Compound Library

Oxygen Sensing Compound Library

Ferroptosis Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Glutamine Metabolism Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Glucose Metabolism Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Serine/Threonine Kinase Inhibitor Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Fibrosis Compound Library

Anti-Brain Cancer Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Anti-Rheumatic Arthritis Compound Library

Lactylation Compound Library

KRAS Targeted Compound Library

Voir tous les produits spécifiques à Isoform Ras

Voir tous les produits spécifiques à Isoform MEK

Voir tous les produits spécifiques à Isoform ERK

Voir tous les produits spécifiques à Isoform Akt

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

SHY-867 Related Classifications

HY-178211 Related Classifications