YSR734
Based on 1 Customer Validation
YSR734 (Compound 21) is a covalent HDAC inhibitor with IC50 values of 110 nM, 154 nM, and 143 nM for HDAC1, HDAC2, and HDAC3, respectively. YSR734 can induce apoptosis in leukemia cells. YSR734 can induce myoblast differentiation and is used in the study of Duchenne muscular dystrophy.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.20%
- CAS No.: 3032969-58-4
- Formule: C26H23F5N4O5S
- Masse moléculaire:598.54
-
Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
-
Apoptosis Compound Library
HY-L003
-
Cell Cycle/DNA Damage Compound Library
HY-L004
-
Epigenetics Compound Library
HY-L005
-
Histone Modification Research Compound Library
HY-L024
-
Anti-Cancer Compound Library
HY-L025
-
Anti-Aging Compound Library
HY-L034
-
Reprogramming Compound Library
HY-L039
-
Oxygen Sensing Compound Library
HY-L045
-
Anti-Breast Cancer Compound Library
HY-L074
-
Anti-Pancreatic Cancer Compound Library
HY-L077
-
Anti-Blood Cancer Compound Library
HY-L079
-
Anti-Liver Cancer Compound Library
HY-L101
-
Osteogenesis Compound Library
HY-L131
-
Cell Death Library
HY-L162
-
Anti-Hematopathy Compound Library
HY-L171
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Bioactive Compound Library
HY-L001
-
Anti-Brain Cancer Compound Library
HY-L188
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Efficiency Gene Editing Compound Library
HY-L244
-
Lactylation Compound Library
HY-L249
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| MV4-11 | IC50 |
0.53 μM
Compound: 21; YSR734
|
Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter-blue viability assay
Cytotoxicity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter-blue viability assay
|
[PMID: 38060537] |
| RS4-11 | IC50 |
1 μM
Compound: 21; YSR734
|
Cytotoxicity against human RS4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter-blue viability assay
Cytotoxicity against human RS4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by celltiter-blue viability assay
|
[PMID: 38060537] |
Chemical Information
-
CAS No. 3032969-58-4
-
Appearance Solid
-
Masse moléculaire 598.54
-
Formule C26H23F5N4O5S
-
Color White to off-white
-
SMILES
NC1=C(NC(C2=CC=C(CNC(OC3CCN(S(=O)(C4=C(F)C(F)=C(F)C(F)=C4F)=O)CC3)=O)C=C2)=O)C=CC=C1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (167.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
-
Fiche technique (274 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6707 mL | 8.3537 mL | 16.7073 mL | 41.7683 mL |
| 5 mM | 0.3341 mL | 1.6707 mL | 3.3415 mL | 8.3537 mL | |
| 10 mM | 0.1671 mL | 0.8354 mL | 1.6707 mL | 4.1768 mL | |
| 15 mM | 0.1114 mL | 0.5569 mL | 1.1138 mL | 2.7846 mL | |
| 20 mM | 0.0835 mL | 0.4177 mL | 0.8354 mL | 2.0884 mL | |
| 25 mM | 0.0668 mL | 0.3341 mL | 0.6683 mL | 1.6707 mL | |
| 30 mM | 0.0557 mL | 0.2785 mL | 0.5569 mL | 1.3923 mL | |
| 40 mM | 0.0418 mL | 0.2088 mL | 0.4177 mL | 1.0442 mL | |
| 50 mM | 0.0334 mL | 0.1671 mL | 0.3341 mL | 0.8354 mL | |
| 60 mM | 0.0278 mL | 0.1392 mL | 0.2785 mL | 0.6961 mL | |
| 80 mM | 0.0209 mL | 0.1044 mL | 0.2088 mL | 0.5221 mL | |
| 100 mM | 0.0167 mL | 0.0835 mL | 0.1671 mL | 0.4177 mL |
YSR734 Related Classifications
HY-161050 Related Classifications
Powered by Bioz