Art. -Nr.: HY-N6687B

Calcimycin hemimagnesium

(Synonyms: A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium)

26 Cited Publications

Kundenbewertung

Based on 26 publication(s) in Google Scholar

Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca²⁺-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis and autophagy.

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CAS. Nr.: 72124-77-7
Formel: C₅₈H₇₂MgN₆O₁₂
Molecular Weight:1069.53

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (286 KB)

Calcimycin hemimagnesium Chemical Structure

CAS. Nr.: 72124-77-7

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Publications (26)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Alle Antibiotic Isoform-spezifische Produkte anzeigen :

In Vitro

Calcimycin (A-23187) hemimagnesium mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Calcimycin (A-23187) hemimagnesium (2.5 or 7.5 nM; intrapleurally) induces protein leakage^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice (ICR, 25-30 g)^[5]
Dosage:

2.5 or 7.5 nM
Administration:

Intrapleurally
Result:

Two hours after 2.5 nM, or three hours after 7.5 nM, challenge the protein levels in the pleural cavity were equivalent to about a half of their corresponding peak values.

Chemical Information

CAS. Nr. 72124-77-7
Molecular Weight 1069.53
Formel C₅₈H₇₂MgN₆O₁₂
SMILES

CNC1=CC=C2OC(C[C@@H]3[C@@H](CC[C@@]4(O3)[C@@H](C[C@H]([C@H](O4)[C@@H](C(C5=CC=CN5)=O)C)C)C)C)=NC2=C1C([O-][Mg+2][O-]C(C6=C7N=C(C[C@H]8O[C@]9(O[C@H]([C@H](C)C(C%10=CC=CN%10)=O)[C@H](C)C[C@H]9C)CC[C@H]8C)OC7=CC=C6NC)=O)=O
Synonyms

A-23187 hemimagnesium; Antibiotic A-23187 hemimagnesium
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (26)

All WBIPIFCell Proliferation/Viability Assay

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Journal Impact Factor

Cancer Commun (Lond)

Cytosolic TGM2 promotes malignant progression in gastric cancer by suppressing the TRIM21-mediated ubiquitination/degradation of STAT1 in a GTP binding-dependent modality. [Abstract]

2023 Jan;43(1):123-149. PMID: 36353796

Calcimycin hemimagnesium purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149. [Abstract]

Cells were treated with different concentrations of Calcimycin (A23187: 2 µmol/L, 4 µmol/L, 8 µmol/L, 10 µmol/L; 24 h), and the effect of A23187 on STAT1 expression was assessed by Western blotting.

Calcimycin hemimagnesium purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149. [Abstract]

Cells were treated with A23187 (4 µmol/L; 24 h) to examine the effect of A21187 on the binding ability of TRIM21 and STAT1 by Co‐IP and western blotting, and the result showed that A23187 reversed the dissociation of TRIM21 and STAT1 in the context of TGM2 and increased ubiquitination of STAT1.

Calcimycin hemimagnesium purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2023 Jan;43(1):123-149. [Abstract]

The effect of A23187 (4 µmol/L; 0-96 h) and ZM39923 (20 nmol/L) on GC cell proliferation was evaluated by CCK8 assay. The result showed that ZM39923 promoted cell proliferation while A23187 had an inhibitory role in GC cell proliferation.
Adv Sci (Weinh)

Succinate Dehydrogenase Subunit A (SDHA) Mediated Microglia Extracellular Traps Formation Participating in Cerebral Ischemic Reperfusion Injury. [Abstract]

2025 Aug 20:e11873. PMID: 40832885

Calcimycin hemimagnesium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 20:e11873. [Abstract]

A23187 (5 µM; 1–6 h) induced apoptosis in microglia in vitro. Microglia viability was assessed using the CCK-8 assay.

Calcimycin hemimagnesium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 20:e11873. [Abstract]

A23187 (5 µM; 4 h). Representative images of microglia stained with Iba1, citH3, and MPO triple staining, and colocalization analysis of MPO, citH3, and DNA in the three cell groups.
Mol Ther

mmu-lncRNA 121686/hsa-lncRNA 520657 induced by METTL3 drive the progression of AKI by targeting miR-328-5p/HtrA3 signaling axis. [Abstract]

2022 Dec 7;30(12):3694-3713. PMID: 35869629
Brain

Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours. [Abstract]

2024 Nov 4;147(11):3764-3779. PMID: 38701344
Proc Natl Acad Sci U S A

Activation of WNK1 signaling through Piezo1. [Abstract]

2025 Sep 2;122(35):e2513155122. PMID: 40880539
Int J Biol Macromol

FKBP5 inhibitor suppresses platelet activation and thrombosis by inhibiting IKBKE/PI3K/Rap1 pathway. [Abstract]

2025 May 7:144068. PMID: 40345291
Phytomedicine

Sinapine targeting PLCβ3 EF hands disrupts Gαq-PLCβ3 interaction and ameliorates cardiovascular diseases. [Abstract]

2024 Apr:126:155200. PMID: 38387273
EMBO Mol Med

Conformational change of adenine nucleotide translocase-1 mediates cisplatin resistance induced by EBV-LMP1. [Abstract]

2021 Dec 7;13(12):e14072. PMID: 34755470
ACS Appl Mater Interfaces

Disrupting Neutrophil Extracellular Traps with Targeted Cerium Oxide Nanoparticles Ameliorates Diabetic Periodontitis. [Abstract]

2026 Apr 22;18(15):21604-21621. PMID: 41972905
Chemosphere

PCB126 impairs human sperm functions by affecting post-translational modifications and mitochondrial functions. [Abstract]

2024 Jan:346:140532. PMID: 37918541
J Med Chem

Optical Control of Leukotriene A4 Hydrolase Using Photoswitchable Inhibitors. [Abstract]

2025 Oct 23;68(20):21520-21533. PMID: 41041960
Antioxidants (Basel)

Muscone and (+)-Borneol Cooperatively Strengthen CREB Induction of Claudin 5 in IL-1 β-Induced Endothelium Injury. [Abstract]

2022 Jul 26;11(8):1455. PMID: 35892657
EMBO Rep

Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance. [Abstract]

2022 Feb 3;23(3):e53373. PMID: 34994492
Ecotoxicol Environ Saf

HFPO homologues, the novel alternatives to PFOA, impair male reproduction in mice through inducing mitochondrial dysfunction. [Abstract]

2025 Jun 2:300:118435. PMID: 40460775
Virulence

Staphylococcus aureus β-hemolysin impairs oxygen transport without causing hemolysis. [Abstract]

2025 Dec;16(1):2490208. PMID: 40202859
Life Sci

MiR-6918-5p prevents renal tubular cell apoptosis by targeting MBD2 in ischemia/reperfusion-induced AKI. [Abstract]

2022 Nov 1:308:120921. PMID: 36057400
PLoS Pathog

LL-37 selectively targets Plasmodium-infected erythrocytes and exhibits antimalarial activity. [Abstract]

2026 Mar 17;22(3):e1014062. PMID: 41843625
Mbio

Calmodulin Binding Activates Chromobacterium CopC Effector to ADP-Riboxanate Host Apoptotic Caspases. [Abstract]

2022 Apr 21;e0069022. PMID: 35446120
J Proteome Res

2026 Feb 25;25(3):1584-1600.
Exp Cell Res

Septins regulate kinase-inhibitor induced micron-scale vacuolation. [Abstract]

2026 Aug 1;461(1):115103. PMID: 42276196
Life Metab

Energy stress-induced PKCζ S-glutathionylation is essential for LKB1 cytoplasmic translocation and AMPK activation. [Abstract]

2025 Jul 16;4(6):loaf027. PMID: 41070197
BMC Cancer

TRPM2 channels mediate ROS-induced actin remodeling and cell migration of prostate cancer cells. [Abstract]

2025 May 28;25(1):956. PMID: 40437388
Thromb J

Endoplasmic reticulum protein 29 negatively regulates platelet functions and thrombosis in mice. [Abstract]

2025 May 7;23(1):44. PMID: 40336049
Res Sq

2026 Feb 12.
Cell Biomater

2026 Jan 12.
bioRxiv

2025 May 05.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wu Q, et al. Characterization of the biosynthesis gene cluster for the pyrrole polyether antibiotic calcimycin(A23187) in Streptomyces chartreusis NRRL 3882. Antimicrob Agents Chemother. 2011 Mar;55(3):974-82. [Content Brief]

[2]. Elliott JI, et al. IKCa1 activity is required for cell shrinkage, phosphatidylserine translocation and death in Tlymphocyte apoptosis. EMBO Rep. 2003 Feb;4(2):189-94. [Content Brief]

[3]. Engedal N, et al. Modulation of intracellular calcium homeostasis blocks autophagosome formation. Autophagy. 2013 Oct;9(10):1475-90. [Content Brief]

[4]. Mawatwal S, et al. Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner. Biochim Biophys Acta Gen Subj. 2017 Dec;1861(12):3190-3200. [Content Brief]

[5]. Wang JP, et al. Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice. Naunyn Schmiedebergs Arch Pharmacol. 1994 Jul;350(1):90-5. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Calcimycin hemimagnesium

26 Cited Publications

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Calcimycin hemimagnesium

Publications Citing Use of MedChemExpress (MCE) Calcimycin hemimagnesium

Alle Antibiotic Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (26)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Calcimycin hemimagnesium Related Classifications

HY-N6687B Related Classifications