Norbixin
Norbixin is a carotenoid that has been found in B. orellana.It binds to PPARγ in a cell-free assay (Ki = 1.15 μM). Norbixin attenuates hyperglycemia, hyperinsulinemia, and insulin resistance, as well as decreases serum lipid levels and cardiac levels of thiobarbituric acid reactive substances (TBARS) and glutathione (GSH) in a rat model of cardio-metabolic syndrome.
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- No. CAS: 542-40-5
- Fòrmula: C24H28O4
- Peso molecular:380.48
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Almacenamiento:
-80°C, protect from light
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 542-40-5
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Appearance Solid
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Peso molecular 380.48
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Fòrmula C24H28O4
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Color Red to reddish brown
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SMILES
O=C(O)/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(O)=O
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Structure Classification
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Initial Source
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Envío
Shipping with dry ice.
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Almacenamiento
-80°C, protect from light
Pureza y Documentación
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Ficha de datos (263 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. A, R., Agrawal, N., Kumar, H., et al. Norbixin, an apocarotenoid derivative activates PPARγ in cardiometabolic syndrome: Validation by in silico and in vivo experimental assessment. Life Sci. 209, 69-77 (2018). [Content Brief]
[2]. Somacal, S., Quatrin, A., Ruviaro, A.R., et al. Norbixin, a natural dye that improves serum lipid profile in rabbits and prevents LDL oxidation. Food Res. Int. 159, 111522 (2022). [Content Brief]
[3]. Barcelos, G.R.M., Grotto, D., Serpeloni, J.M., et al. Bixin and norbixin protect against DNA-damage and alterations of redox status induced by methylmercury exposure in vivo. Environ. Mol. Mutagen. 53(7), 535-541 (2012). [Content Brief]
[4]. Fontaine, V., Monteiro, E., M., F., et al. Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease. Aging (Albany N.Y.) 12(7), 6151-6171 (2020). [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Norbixin Related Classifications
HY-W587784 Related Classifications
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