YS-49 monohydrate
Based on 17 publication(s) in Google Scholar
YS-49 (monohydrate) is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.
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- Pureza: 99.56%
- No. CAS: 3028631-24-2
- Fòrmula: C20H22BrNO3
- Peso molecular:404.30
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) YS-49 monohydrate
More- Signal Transduct Target Ther. 2021 Jun 18;6(1):234. [Abstract]
- Sci China Life Sci. 2025 Mar;68(3):746-763. [Abstract]
- Mater Des. 2026 May 30;267:116311.
- Front Immunol. 2021 Oct 15;12:699478. [Abstract]
- Biochem Pharmacol. 2024 May:223:116112. [Abstract]
- J Ethnopharmacol. 2026 Jul 15:366:121662. [Abstract]
- Mol Ther Oncolytics. 2022 Aug 5:26:360-371. [Abstract]
- Commun Biol. 2026 Jan 23;9(1):311. [Abstract]
- Pharm Biol. 2023 Dec;61(1):541-555. [Abstract]
- Cancers (Basel). 2022 Jun 21;14(13):3039. [Abstract]
- Sci Rep. 2023 Sep 12;13(1):15036. [Abstract]
- Mol Med Rep. 2025 Apr;31(4):95. [Abstract]
- J Anim Sci. 2025 Jan 4:103:skaf266. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- BMC Musculoskelet Disord. 2025 Oct 14;26(1):961. [Abstract]
- Int J Rheum Dis. 2024 Jun 22.
- SSRN. 2026 Mar 10.
Ver todos los productos específicos de isoformas Angiotensin Receptor
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Actividad biológica
PI3K/Akt[3]
YS-49 (1-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30?μM, respectively[2].
YS-49 (10-100?μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAVSMC and RAW 264.7 cells
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Concentration:10 μΜ, 30 μΜ and 100 μΜ(RAVSMC); 1 μΜ, 10 μΜ and 100 μM (RAW 264.7)
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Incubation Time:18 hours
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Result:Inhibited the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to LPS+INF-γ, with IC50 values of 22 and 30 μM, respectively.
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Cell Line:RAVSMC and RAW 264.7 cells
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Concentration:10 μΜ, 30 μΜ and 100 μΜ
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Incubation Time:18 hours
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Result:Concentration-dependently inhibited the expression of iNOS protein induced by LPS plus IFN-γ.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats (250-300 g)[2]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; 8 hours
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Result:Serum NOx levels were significantly reduced.
Chemical Information
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No. CAS 3028631-24-2
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Appearance Solid
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Peso molecular 404.30
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Fòrmula C20H22BrNO3
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Color Off-white to gray
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SMILES
OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.O.Br
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (17)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity. [Abstract]2021 Jun 18;6(1):234. PMID: 34140465 -
Sci China Life Sci
Integrating spatial transcriptomics and single-nucleus RNA-seq revealed the specific inhibitory effects of TGF-β on intramuscular fat deposition. [Abstract]2025 Mar;68(3):746-763. PMID: 39422812 -
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Front Immunol
"γδT Cell-IL17A-Neutrophil" Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy. [Abstract]2021 Oct 15;12:699478. PMID: 34721375 -
Biochem Pharmacol
Columbianadin suppresses glioblastoma progression by inhibiting the PI3K-Akt signaling pathway. [Abstract]2024 May:223:116112. PMID: 38458331 -
J Ethnopharmacol
Huangqin Qingre Chubi Capsule modulates the lncRNA AP005432.1/PI3K/AKT axis and is associated with improved self-perception of patients and inflammation in ankylosing spondylitis. [Abstract]2026 Jul 15:366:121662. PMID: 41956229 -
Mol Ther Oncolytics
2022 Aug 5:26:360-371. PMID: 36090473 -
Commun Biol
DTX1-mediated degradation of TUBB3 in Kupffer cells mitigates hepatocellular carcinoma progression by regulating M1/M2 polarization. [Abstract]2026 Jan 23;9(1):311. PMID: 41577987 -
Pharm Biol
Chinese herbal compound Huangqin Qingrechubi capsule reduces lipid metabolism disorder and inflammatory response in gouty arthritis via the LncRNA H19/APN/PI3K/AKT cascade. [Abstract]2023 Dec;61(1):541-555. PMID: 36994890 -
Cancers (Basel)
2022 Jun 21;14(13):3039. PMID: 35804814 -
Sci Rep
The inhibition of pancreatic cancer progression by K-Ras-overexpressing mesenchymal stem cell-derived secretomes. [Abstract]2023 Sep 12;13(1):15036. PMID: 37699930 -
Mol Med Rep
Mechanism of β‑sitosterol in treating keloids: Network pharmacology, molecular docking and experimental verification. [Abstract]2025 Apr;31(4):95. PMID: 39981895 -
J Anim Sci
Roles of JNK, ERK, and PI3K/AKT signaling pathways in zinc-mediated alleviation of thermal stress-induced damage to the integrity and barrier function of primary cultured chick jejunal epithelial cells. [Abstract]2025 Jan 4:103:skaf266. PMID: 40795135 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
BMC Musculoskelet Disord
YS-49 activates the PI3K/AKT signaling pathway in MC3T3-E1 cells to enhance osteoblast differentiation and inhibits glucocorticoid-induced bone loss in vivo. [Abstract]2025 Oct 14;26(1):961. PMID: 41088103 -
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Pureza y Documentación
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Ficha de datos (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Sun JJ, et al. YS 49, 1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. Life Sci. 2008 Mar 12;82(11-12):600-7. [Content Brief]
[2]. Kang YJ, et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999 Sep;128(2):357-64. [Content Brief]
[3]. Hsu YH, et al. RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. J Cell Physiol. 2014 Oct;229(10):1455-65. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
YS-49 monohydrate Related Classifications
HY-15477A Related Classifications
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