Referencia número: HY-100395

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F16

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Pureza: 99.94%
No. CAS: 36098-33-6
Fòrmula: C₁₆H₁₅IN₂
Peso molecular:362.21

Almacenamiento:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

F16 Chemical Structure

No. CAS: 36098-33-6

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Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
- Ensayo clínico
Chemical Information
Solvente y solubilidad
- In Vitro
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

F16 is a potent growth inhibitor of the neu-overexpressing cells and also selectively inhibits proliferation of mammary epithelial as well as a variety of mouse mammary tumor and human breast cancer cell lines. F16 is a mitochondriotoxic compound, and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>100 μM Compound: F16	Cytotoxicity against human A549 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38169372]
A549	IC₅₀	>60 μM Compound: F16	Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38086195]
BEAS-2B	IC₅₀	>100 μM Compound: F16	Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human BEAS-2B cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38169372]
HepG2	IC₅₀	>60 μM Compound: F16	Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38086195]
L02	IC₅₀	>60 μM Compound: F16	Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HL7702 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38086195]
MCF7	IC₅₀	>100 μM Compound: F16	Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38169372]
NCI-H1975	IC₅₀	>50 μM Compound: F16	Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human NCI-H1975 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38169372]
NCI-H446	IC₅₀	>60 μM Compound: F16	Antiproliferative activity against human NCI-H446 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Antiproliferative activity against human NCI-H446 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 38086195]
NCI-H460	IC₅₀	>50 μM Compound: F16	Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as inhibition of cell viability incubated for 48 hrs by MTT assay	[PMID: 38169372]

In Vitro

F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines^[1].
F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMG
Concentration:

3 μM
Incubation Time:

3 days/7 days
Result:

Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras-transgenic mice was not affected.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 36098-33-6
Appearance Solid
Peso molecular 362.21
Fòrmula C₁₆H₁₅IN₂
Color Yellow to orange
SMILES

C[N+]1=CC=C(/C=C/C2=CNC3=C2C=CC=C3)C=C1.[I-]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad

In Vitro:

DMSO : ≥ 31 mg/mL (85.59 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 1 mg/mL (2.76 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.7608 mL

13.8041 mL

27.6083 mL

5 mM

0.5522 mL

2.7608 mL

5.5217 mL

10 mM

0.2761 mL

1.3804 mL

2.7608 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (285 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Fantin VR et al. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2002 Jul;2(1):29-42. [Content Brief]

[2]. Fantin VR et al. F16, a mitochondriotoxic compound, triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell. Cancer Res. 2004 Jan 1;64(1):329-36. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	2.7608 mL	13.8041 mL	27.6083 mL	69.0207 mL
DMSO	5 mM	0.5522 mL	2.7608 mL	5.5217 mL	13.8041 mL
	10 mM	0.2761 mL	1.3804 mL	2.7608 mL	6.9021 mL
	15 mM	0.1841 mL	0.9203 mL	1.8406 mL	4.6014 mL
	20 mM	0.1380 mL	0.6902 mL	1.3804 mL	3.4510 mL
	25 mM	0.1104 mL	0.5522 mL	1.1043 mL	2.7608 mL
	30 mM	0.0920 mL	0.4601 mL	0.9203 mL	2.3007 mL
	40 mM	0.0690 mL	0.3451 mL	0.6902 mL	1.7255 mL
	50 mM	0.0552 mL	0.2761 mL	0.5522 mL	1.3804 mL
	60 mM	0.0460 mL	0.2301 mL	0.4601 mL	1.1503 mL
	80 mM	0.0345 mL	0.1726 mL	0.3451 mL	0.8628 mL

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F16

Anti-Breast Cancer Compound Library

Targeted Diversity Library

Heterocyclic Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

F16

Anti-Breast Cancer Compound Library

Targeted Diversity Library

Heterocyclic Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

High-Throughput Bioactive Compound Library

Apoptosis Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Actividad biológica

Chemical Information

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

F16 Related Classifications

HY-100395 Related Classifications