Referencia número: HY-N0153

Naringin

(Synonyms: Naringoside)

27 Cited Publications

Revisión del cliente

Based on 27 publication(s) in Google Scholar

Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin also inhibits proliferation and invasion and induces apoptosis in human osteosarcoma cells by inhibiting zinc finger E-box binding homeobox 1 (Zeb1).

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Pureza: 99.65%
No. CAS: 10236-47-2
Fòrmula: C₂₇H₃₂O₁₄
Peso molecular:580.53

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months

Naringin Chemical Structure

No. CAS: 10236-47-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- Cellular Effect
- In Vitro
- In Vivo
- Ensayo clínico
Chemical Information
Publications (27)
Solvente y solubilidad
- In Vitro
- In Vivo
Protocolo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

Ver todos los productos específicos de isoformas Cytochrome P450 :

Ver todos los productos específicos de isoformas Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
Monocyte	IC₅₀	>200 μM Compound: Naringin	Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA	[PMID: 10096854]
Oocyte	EC₅₀	>100 μM Compound: Naringin	Activation of recombinant human GIRK1/2 expressed in Xenopus oocytes by two-electrode voltage clamp method Activation of recombinant human GIRK1/2 expressed in Xenopus oocytes by two-electrode voltage clamp method	[PMID: 23916258]
Oocyte	EC₅₀	>100 μM Compound: Naringin	Activation of recombinant human GIRK1/4 expressed in Xenopus oocytes by two-electrode voltage clamp method Activation of recombinant human GIRK1/4 expressed in Xenopus oocytes by two-electrode voltage clamp method	[PMID: 23916258]

In Vitro

Naringin suppresses NF-κ B signaling pathway activation. Naringenin inhibits high glucose-induced proliferation, inflammatory reaction and oxidative stress injury in HBZY-1 cells^[1]. Naringin inhibits AGS cancer cell proliferation in a dose- and time-dependent manner. Phosphorylation of PI3K and its activated downstream targets p-Akt and p-mTOR are significantly decreased at 2 mM in Naringin-treated AGS cells. Naringin induces autophagic cell death in AGS cells. Naringin activated the autophagy related protein in AGS cells^[2]. Naringin protects PC12 cells from 3-NP neurotoxicity. The lactate dehydrogenase release is decreased upon naringin treatment in 3-NP-induced PC12 cells. Naringin treatment enhances the antioxidant defense by increasing the activities of enzymatic antioxidants and the level of reduced glutathione^[3].
Naringin (10, 20 μM, 24 h) inhibits the expression of Zeb1, proliferation and migration in osteosarcoma cells and induces apoptosis^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Treatment with naringin significantly alleviates renal injury in diabetic rats and increases diabetic rats body weight significantly. Administration of naringin effectively alleviates the collagen deposition and renal interstitial fibrosis in diabetic rats. Treatment with naringin could result in decreased levels of ROS and MDA and increased activities of SOD and GSH-Px^[1]. Oral administration of naringin significantly improves the learning and memory abilities. Naringin significantly enhances insulin signaling pathway^[3].
Naringin (5,10 mg/kg, iv, daily for 16 d) inhibits the invasion of MG63 cells in nude BALB/c mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 10236-47-2
Appearance Solid
Peso molecular 580.53
Fòrmula C₂₇H₃₂O₁₄
Color White to light yellow
SMILES

O=C1C[C@@H](C2=CC=C(O)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O[C@@]5([H])[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)=CC(O)=C13
Synonyms

Naringoside
Structure Classification
- Flavonoids
- Flavonones
Initial Source
- Endogenous metabolite
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	1 year
	-20°C	6 months

Publications (27)

All Bio/Physico-chemical AssayIn Vivo Efficacy StudyHistological Imaging/Staining

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Journal Impact Factor

Chem Eng J

2025 Jul 1.
Phytomedicine

Modified Fuzheng Yiliu Decoction chemosensitizes colorectal cancer by inhibiting cancer stem cell metabolism and stemness through CAV1/ZNF460/GRP78 signaling. [Abstract]

2026 Jul 25:157:158317. PMID: 42177885
Phytomedicine

Inhibiting VEGFC - mediated hepatocyte - macrophage regulatory axis contributes to protective effects of naringin against high - fat diet - induced hepatic fibrosis. [Abstract]

2026 Jan:150:157682. PMID: 41447848
Mater Today Bio

A nano-immuno-cruise delivery system encapsulated lipid-integrated bilayer ameliorate acute lung injury by interfering neutrophil infiltration. [Abstract]

2025 Nov 17:35:102563. PMID: 41377585

Naringin purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Nov 17:35:102563. [Abstract]

The release curves of LP@Naringin, TK-LP@Naringin, and TK-NLP@Naringin with varying concentrations of H₂O₂.

Naringin purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2025 Nov 17:35:102563. [Abstract]

Miniature CT images show the therapeutic effect of TK-NLP@Naringin on LPS-induced ALI mice.
J Orthop Translat

Naringin inhibits the osteoblast-osteoclast pyroptosis cascade reaction mediated by accumulated bone marrow adipose tissue in the treatment of postmenopausal osteoporosis. [Abstract]

2025 Oct 1:55:323-338. PMID: 41104349

Naringin purchased from MedChemExpress. Usage Cited in: J Orthop Translat. 2025 Oct 1:55:323-338. [Abstract]

As shown, a mice PMOP model was established by OVX, and the mice were treated with the established clinical therapy ALD or different concentrations of Naringin (10-40 mg/kg) by gavage for eight weeks to observe the changes in their bone phenotypes.

Naringin purchased from MedChemExpress. Usage Cited in: J Orthop Translat. 2025 Oct 1:55:323-338. [Abstract]

As shown, a mice PMOP model was established by OVX, and the mice were treated with the established clinical therapy ALD or different concentrations of Naringin (10-40 mg/kg) by gavage for eight weeks to observe the changes in their bone phenotypes. Representative μCT-reconstructed images of trabecular bone at the distal femur.

Naringin purchased from MedChemExpress. Usage Cited in: J Orthop Translat. 2025 Oct 1:55:323-338. [Abstract]

As shown, a mice PMOP model was established by OVX, and the mice were treated with the established clinical therapy ALD or different concentrations of Naringin (10-40 mg/kg) by gavage for eight weeks to observe the changes in their bone phenotypes. Representative images of HE staining.
Br J Pharmacol

Silibinin, a commonly used therapeutic agent for non-alcohol fatty liver disease, functions through upregulating intestinal expression of fibroblast growth factor 15/19. [Abstract]

2024 Oct;181(19):3663-3684. PMID: 38839561
J Ethnopharmacol

Duhuo Jisheng decoction alleviates intervertebral disc degeneration by inhibiting nucleus pulposus cell pyroptosis via gallic acid-mediated downregulation of HIF-1α. [Abstract]

2026 Mar 1:358:120957. PMID: 41317810
Biochem Pharmacol

Naringin affects VEGFC/TGF-β1 to mediate intercellular communication in MASH through coordinated Src and p38 MAPK pathways. [Abstract]

2026 Sep;251(Pt 1):118009. PMID: 42044813
J Zhejiang Univ Sci B

Aerobic glycolysis in colon cancer is repressed by naringin via the HIF1Α pathway. [Abstract]

2023 Mar 15;24(3):221-231. PMID: 36915998
Bone Joint Res

Naringin targets TGF-β1-mediated angiogenesis to enhance the osteogenic effect of induced membrane. [Abstract]

2026 May 22;15(5):549-565. PMID: 42172046
Front Pharmacol

Naringin Ameliorates Monocrotaline-Induced Pulmonary Arterial Hypertension Through Endothelial-To-Mesenchymal Transition Inhibition. [Abstract]

2021 Jul 15:12:696135. PMID: 34335261
Mol Med Rep

Tea seed saponin‑reduced extract ameliorates palmitic acid‑induced insulin resistance in HepG2 cells. [Abstract]

2024 Feb;29(2):26. PMID: 38099345
Mol Med Rep

Naringin induces apoptosis of gastric carcinoma cells via blocking the PI3K/AKT pathway and activating pro‑death autophagy. [Abstract]

2021 Nov;24(5):772. PMID: 34490484
Sci Rep

Naringin promotes osteoblast differentiation and ameliorates osteoporosis in ovariectomized mice. [Abstract]

2025 Apr 12;15(1):12651. PMID: 40221578
Plants

Determination of Flavonoid Glycoside Isomers Using Vision Transformer and Tandem Mass Spectrometry. [Abstract]

2024 Dec 4;13(23):3401. PMID: 39683194
Fish Shellfish Immunol

Emodin enhances host antiviral immunity against Micropterus salmoides rhabdovirus by activating RLR signaling in largemouth bass. [Abstract]

2025 Nov:166:110633. PMID: 40769268
Mol Biol Rep

Naringin mitigates liver damage in a tissue-engineered liver of metabolic dysfunction-associated steatotic liver disease model by promoting autophagy via the mTOR-ULK1 pathway. [Abstract]

2025 Oct 9;52(1):1000. PMID: 41066001
Mol Biol Rep

Mechanisms of autophagy and endoplasmic reticulum stress in the reversal of platinum resistance of epithelial ovarian cancer cells by naringin. [Abstract]

2023 Aug;50(8):6457-6468. PMID: 37326754
J Mol Neurosci

Naringin Targets NFKB1 to Alleviate Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury in PC12 Cells Via Modulating HIF-1α/AKT/mTOR-Signaling Pathway. [Abstract]

2021 Jan;71(1):101-111. PMID: 32557145
Braz J Med Biol Res

Naringin regulates mitochondrial dynamics to protect against acetaminophen-induced hepatotoxicity by activating the AMPK/Nrf2 signaling pathway in vitro. [Abstract]

2022 Oct 17;55:e12040. PMID: 36259797
Lett Drug Des Discov

2025 Dec 13.
Res Sq

2025 Apr 21.
SSRN

2024 Jan 26.
Evid Based Complement Alternat Med

Naringin Prevents Cognitive Dysfunction in Aging Rats by Inhibiting Toll-Like Receptor 4 (TLR4)/NF- κ B Pathway and Endoplasmic Reticulum Stress. [Abstract]

2023 Feb 21:2023:2919811. PMID: 36865741
Environ Toxicol

Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation. [Abstract]

2022 Jun;37(6):1332-1342. PMID: 35179299
Authorea

October 20, 2021.
Universitat Politècnica de València

2020 Sep 7.

Solvente y solubilidad

In Vitro:

DMSO : 125 mg/mL (215.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.7226 mL

8.6128 mL

17.2256 mL

5 mM

0.3445 mL

1.7226 mL

3.4451 mL

10 mM

0.1723 mL

0.8613 mL

1.7226 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.08 mg/mL (3.58 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (3.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (3.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 50% PEG300 50% Saline

Solubility: 40 mg/mL (68.90 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Protocolo

Cell Assay^[1]

HBZY-1 cells are plated into 96-well plates and pretreated with various concentrations(1, 5, 10, 25, 50, 100 μM) of naringin for 2 h. Then cells are treated with 30 mM glucose for 24 h. The control group is added sterile normal saline in the same volume. After treatment, all the wells are incubated with 20 μL of 5 mg/ml MTT for 4 h at 37°C. Subsequently, 100 μL of DMSO are used to dissolve the formed formazan crystals after removal of the supernatant. The result is recorded at 490 nm on a microplate reader^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration^[1]^[4]

Rats: The rats are randomly divided into six groups: control, naringin (80 mg/kg), STZ, STZ+naringin (20 mg/kg), STZ+naringin (40 mg/kg), STZ+naringin(80 mg/kg). The rats in the STZ and STZ+naringin groups are intraperitoneally injected with STZ (65 mg/kg). The control and naringin groups are intraperitoneally injected with 0.1 M citrate buffer of same volume. After injection of STZ for 3 and 5 days, blood glucose levels are measured by tail vein puncture blood sampling^[1].

Mice: Sixty 4-week-old male mice are randomized into four groups and fed for 20 weeks with either control diet or high-fat diet chow. Mice are dosed with 100 mg/kg of naringin daily. Mice body weight and food intake are weekly measured. Following behavioral assessment, animals are deeply anesthetized with isoflurane and sacrificed by decapitation after fasting for at least 5 h. Their plasma is collected for further analysis^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (282 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Chen F, et al. Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction. PLoS One. 2015 Nov 30;10(11):e0143868. [Content Brief]

[2]. Raha S, et al. Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells. Int J Oncol. 2015 Sep;47(3):1061-9. [Content Brief]

[3]. Kulasekaran G, et al. Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells. Mol Cell Biochem. 2015 Nov;409(1-2):199-211. [Content Brief]

[4]. Wang D, et al. Naringin Improves Neuronal Insulin Signaling, Brain Mitochondrial Function, and Cognitive Function in High-Fat Diet-Induced Obese Mice. Cell Mol Neurobiol. 2015 Oct;35(7):1061-71. [Content Brief]

[5]. Ming H, et al. Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis. Aging (Albany NY). 2018 Dec 22;10(12):4141-4151. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.7226 mL	8.6128 mL	17.2256 mL	43.0641 mL
	5 mM	0.3445 mL	1.7226 mL	3.4451 mL	8.6128 mL
	10 mM	0.1723 mL	0.8613 mL	1.7226 mL	4.3064 mL
	15 mM	0.1148 mL	0.5742 mL	1.1484 mL	2.8709 mL
	20 mM	0.0861 mL	0.4306 mL	0.8613 mL	2.1532 mL
	25 mM	0.0689 mL	0.3445 mL	0.6890 mL	1.7226 mL
	30 mM	0.0574 mL	0.2871 mL	0.5742 mL	1.4355 mL
	40 mM	0.0431 mL	0.2153 mL	0.4306 mL	1.0766 mL
	50 mM	0.0345 mL	0.1723 mL	0.3445 mL	0.8613 mL
	60 mM	0.0287 mL	0.1435 mL	0.2871 mL	0.7177 mL
	80 mM	0.0215 mL	0.1077 mL	0.2153 mL	0.5383 mL
	100 mM	0.0172 mL	0.0861 mL	0.1723 mL	0.4306 mL

Keywords

Naringin

27 Cited Publications

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Naringin

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Publications Citing Use of MedChemExpress (MCE) Naringin

Ver todos los productos específicos de isoformas Cytochrome P450

Ver todos los productos específicos de isoformas Endogenous Metabolite

Actividad biológica

Chemical Information

Publications (27)

Solvente y solubilidad

Protocolo

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Naringin Related Classifications

HY-N0153 Related Classifications