Altertoxin I
Based on 1 Customer Validation
Altertoxin I (Dihydroalterperylenol; ATX-I) is a quinone mycotoxin with immunosuppressive, mutagenic and anticancer activities. Altertoxin I inhibits LPS (HY-D1056)-mediated NF-κB activation and estrogen-dependent alkaline phosphatase activity. Altertoxin I activates the AhR signaling pathway, induces the expression of CYP 1A1/1A2/1B1 and the enzymatic activity of EROD. Altertoxin I can be used in breast cancer research.
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- Pureza: 99.16%
- No. CAS: 56258-32-3
- Fòrmula: C20H16O6
- Peso molecular:352.34
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Actividad biológica
Altertoxin I (0.001-20 μM; 20 h) suppresses LPS-induced NF-κB pathway activation in THP1-Lucia™ monocytes with significant effects starting at 1 μM, and does not induce cytotoxicity at concentrations up to 20 μM[1].
Altertoxin I (0.0002-10 μM; 48 h) exerts antiestrogenic effects in Ishikawa cells by suppressing E2-induced alkaline phosphatase activity with significant effects starting at 2 μM, and does not induce cytotoxicity at concentrations up to 10 μM[1].
Altertoxin I (0.01-5 µM; 24 h) dose-dependently induces EROD enzyme activity in MCF-7 human mammary breast cancer cells, with significant activation starting at 2.5 µM[2].
Altertoxin I (0.01-5 µM; 24 h) enhances metabolic activity in MCF-7 human mammary breast cancer cells at 5 µM without reducing cell metabolic activity at lower tested concentrations[2].
Altertoxin I (20 μM; 24 h) exhibits minimal cytotoxicity in A549, HeLa, U2OS, and HepG2 cancer cell lines[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human mammary breast cancer MCF-7 cells
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Concentration:0.01 µM, 0.1 µM, 1 µM, 2.5 µM, 5 µM
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Incubation Time:24 h
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Result:Did not compromise cell metabolic activity at any tested concentration.
Induced a significant enhancement of metabolic activity at 5 µM, reaching approximately 130% of solvent control.
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Cell Line:A549, HeLa, U2OS, HepG2
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Concentration:20 μM
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Incubation Time:24 h
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Result:Maintained cell viability near control levels across all four tested cancer cell lines.
Showed no significant growth inhibition.
Chemical Information
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No. CAS 56258-32-3
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Appearance Solid
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Peso molecular 352.34
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Fòrmula C20H16O6
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Color Light yellow to yellow
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SMILES
O=C(C1=C2C3=CC=C1O)CC[C@]2([C@@]([H])(C4=C3C=CC(O)=C45)[C@H](CC5=O)O)O
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Synonyms
Dihydroalterperylenol; ATX-I
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Structure Classification
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Initial Source
Alternaria alternata
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Crudo F, et al. Discovery of the Alternaria mycotoxins alterperylenol and altertoxin I as novel immunosuppressive and antiestrogenic compounds in vitro. Archives of toxicology. 2025 Jan;99(1):407-421. [Content Brief]
[2].
Hohenbichler J, et al Alternaria alternata Toxins Synergistically Activate the Aryl Hydrocarbon Receptor Pathway In Vitro. Biomolecules. 2020 Jul 9;10(7):1018.
[Content Brief]
[3]. Xi J, et al. Alterperylenol as a Novel Thioredoxin Reductase Inhibitor Induces Liver Cancer Cell Apoptosis and Ferroptosis. Journal of agricultural and food chemistry. 2022 Dec 21;70(50):15763-15775. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Altertoxin I Related Classifications
HY-N6724 Related Classifications
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