AS1604498
AS1604498 is a highly specific competitive inhibitor of human NAMPT, with an IC50 of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis. AS1604498 is applicable to research related to chronic myeloid leukemia.
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- No. CAS: 361465-74-9
- Fòrmula: C19H17N3O2
- Peso molecular:319.36
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
AS1604498 (0.032-10 μM; 48 h) inhibits THP-1 human leukemia cell growth with an IC50 of 198 nM, and this effect is reversed by 10 mM Nicotinamide (HY-B0150)[1].
AS1604498 (0.032-10 μM; 48 h) inhibits K562 human chronic myelogenous leukemia cell growth with an IC50 of 673 nM, and this effect is reversed by 10 mM Nicotinamide[1].
AS1604498 (10 μM; 48 h) induces delayed caspase 3/7 activation in THP-1 cells, and this activation is reversed by 10 mM Nicotinamide[1].
AS1604498 (0.001-10 μM; 5 h) reduces intracellular NAD levels in K562 cells in a dose-dependent manner, and this effect is reversed by 10 mM Nicotinamide[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1 human leukemia cell
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Concentration:0.032, 0.1, 0.32, 1, 3.2, 10 μM
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Incubation Time:48 h
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Result:Dose-dependently inhibited THP-1 cell proliferation, with an IC50 of 198 nM (equivalent to 198 nM).
Was completely reversed in growth inhibitory effect by the addition of 10 mM nicotinamide.
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Cell Line:K562 human chronic myelogenous leukemia cell
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Concentration:0.032, 0.1, 0.32, 1, 3.2, 10 μM
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Incubation Time:48 h
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Result:Dose-dependently inhibited K562 cell proliferation, with an IC50 of 673 nM (equivalent to 673 nM).
Was completely reversed in growth inhibitory effect by the addition of 10 mM nicotinamide.
Chemical Information
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No. CAS 361465-74-9
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Peso molecular 319.36
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Fòrmula C19H17N3O2
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SMILES
O=C(NCCCN1C=NC=C1)C=2OC(C#CC=3C=CC=CC3)=CC2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS1604498 Related Classifications
HY-119159 Related Classifications
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- AS1604498
- 361465-74-9
- AS 1604498
- AS-1604498
- NAMPT
- Caspase
- Apoptosis
- NAMPT dimer interface pocket
- cancer cells
- K562 human chronic myelogenous leukemia cell
- NAMPT enzyme activity
- caspase 3/7
- human NAMPT
- chronic myelogenous leukemia
- THP-1 human leukemia cell
- intracellular NAD levels
- nicotinamide mononucleotide
- Inhibitor
- inhibitor
- inhibit