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Referencia número: HY-134914

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Fosmidomycin

2 Cited Publications

Revisión del cliente

Based on 2 publication(s) in Google Scholar

Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase). Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC₅₀s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model.

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No. CAS: 66508-53-0
Fòrmula: C₄H₁₀NO₅P
Peso molecular:183.10

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

Fosmidomycin Chemical Structure

No. CAS: 66508-53-0

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Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	IC₅₀	>62 μM Compound: 1	Cytotoxicity against human MRC5 cells Cytotoxicity against human MRC5 cells	[PMID: 21866890]

Chemical Information

No. CAS 66508-53-0
Peso molecular 183.10
Fòrmula C₄H₁₀NO₅P
SMILES

OP(O)(CCCN(C=O)O)=O
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces lavendulae
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Plant Sci

Adjusting function of camphor on primary metabolism in Cinnamomum camphora stressed by high temperature. [Abstract]

2024 Feb:339:111956. PMID: 38101618
ACS Infect Dis

Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium falciparum. [Abstract]

2024 Dec 13;10(12):4073-4086. PMID: 39631773

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Wiesner J, et al., In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin. Antimicrob Agents Chemother. 2002 Sep;46(9):2889-94. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Fosmidomycin

2 Cited Publications

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Fosmidomycin

Publications Citing Use of MedChemExpress (MCE) Fosmidomycin

Ver todos los productos específicos de isoformas Antibiotic

Ver todos los productos específicos de isoformas Parasite

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Publications (2)

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Fosmidomycin Related Classifications

HY-134914 Related Classifications