Nudol
Based on 1 Customer Validation
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits MMP-2M and MMP-9 activity (Ki: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma.
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- Pureza: 99.60%
- No. CAS: 86630-46-8
- Fòrmula: C16H14O4
- Peso molecular:270.28
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
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MMP-2 988.9 nM (Ki) |
MMP-9 1.76 μM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μM
Compound: 15
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Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 6 days by MTT assay
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[PMID: 27310249] |
| HeLa | IC50 |
>10 μM
Compound: 15
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Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability after 6 days by MTT assay
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[PMID: 27310249] |
| HSC-T6 | IC50 |
>100 μM
Compound: 13
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Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay
Antiproliferative activity against rat HSC-T6 cells after 48 hrs by MTT assay
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[PMID: 18052323] |
| MCF7 | IC50 |
>10 μM
Compound: 15
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Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 6 days by MTT assay
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[PMID: 27310249] |
| Neutrophil | IC50 |
>10 μM
Compound: 11
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Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction
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[PMID: 27525452] |
| Neutrophil | IC50 |
1.7 μM
Compound: 11
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Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal
Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal
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[PMID: 27525452] |
Nudol (0-40 μM, 24-72 h) decreases cell viability in several cancer cell lines[1].
Nudol (0-20 μM, 24/48 h) suppresses the cell migration and causes cell cycle arrest at G2/M phase in U2OS cells[1].
Nudol (20 μM, 48 h) induces cell apoptosis through the caspase-dependent pathway in U2OS cells[1].
Nudol (compound 4) inhibits MMP-2 and MMP-9 activity with Ki values of 988.9 nM and 1.76 μM respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:U2OS, MG63, MDA-MB-231, MCF-7, and A549 cells
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Concentration:0, 10, 20, 30, 40 μM
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Incubation Time:24, 48, and 72 h
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Result:Decreased the cell viability of osteosarcoma cells in dose- and time-dependent manners.
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Cell Line:U2OS cells
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Concentration:0, 5, 10, 20 μM
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Incubation Time:24, 48, and 72 h
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Result:Triggered G2/M phase arrest by decreasing cell cycle-related proteins (CDK1, CDK2, CDK4, and CDK10).
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Cell Line:U2OS cells
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Concentration:0, 5, 10, 20, 40 μM
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Incubation Time:24, 48, and 72 h
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Result:Increased the protein level of cytochrome c.
Down-regulated anti-apoptotic Bcl-2, accompanied by an increased level of pro-apoptotic Bax.
Chemical Information
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No. CAS 86630-46-8
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Appearance Solid
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Peso molecular 270.28
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Fòrmula C16H14O4
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Color Off-white to light brown
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SMILES
OC1=C(OC)C(OC)=C2C3=CC=C(O)C=C3C=CC2=C1
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Pureza y Documentación
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Ficha de datos (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nudol Related Classifications
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