SJ-C1044
Based on 1 Customer Validation
SJ-C1044 is an orally available pan-RAF inhibitor with immunomodulatory and anti-tumor activities. SJ-C1044 inhibits wild-type BRAF, wild-type CRAF, and BRAF (V600E) with IC50 values ??of 331, 257, and 187 nM, respectively. SJ-C1044 inhibits tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. In addition, SJ-C1044 also has a certain inhibitory effect on VEGFR2, TIE2, and CSF1R, with IC50 values ??of 100, 23, and 235 nM, respectively. SJ-C1044 improves the tumor immune microenvironment by inhibiting angiogenesis and regulating macrophage function. SJ-C1044 can be used in the study of colorectal cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 98.63%
- No. CAS: 2121503-76-0
- Fòrmula: C25H14F7N7O
- Peso molecular:561.41
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Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Protocolo
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas MEK
MoreVer todos los productos específicos de isoformas VEGFR
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
VEGFR2 100 nM (IC50) |
BRAFWT 331 nM (IC50) |
BRafV600E 187 nM (IC50) |
CRAF 257 nM (IC50) |
Tie2 23 nM (IC50) |
CSF1R 235 nM (IC50) |
Chemical Information
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No. CAS 2121503-76-0
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Appearance Solid
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Peso molecular 561.41
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Fòrmula C25H14F7N7O
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Color Light yellow to green yellow
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SMILES
FC(C(NC(C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)=C2)=CC=C2NC3=NC=CC=C3C4=NC=NC5=C4N=CN5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvente y solubilidad
In Vitro:
DMSO : 5.83 mg/mL (10.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7812 mL | 8.9061 mL | 17.8123 mL | 44.5307 mL |
| 5 mM | 0.3562 mL | 1.7812 mL | 3.5625 mL | 8.9061 mL | |
| 10 mM | 0.1781 mL | 0.8906 mL | 1.7812 mL | 4.4531 mL |
SJ-C1044 Related Classifications
HY-164529 Related Classifications
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Keywords
- SJ-C1044
- 2121503-76-0
- Raf
- Ras
- MEK
- ERK
- VEGFR
- Tie
- c-Fms
- Raf kinases
- Mitogen-activated protein kinase kinase
- MAPKK
- MAP2K
- Extracellular signal regulated kinases
- Vascular endothelial growth factor receptor
- Angiopoietin receptor
- CSF-1 receptor
- colony stimulating factor 1 receptor
- CSF-1R
- CSF1R
- Inhibitors
- Immunomodulatory
- Antiproliferative
- Tumor Microenvironment
- Angiogenesis
- Macrophages
- Inhibitor
- inhibitor
- inhibit