Cys1 - cystin 1 Gene

Also Known as ck; cpk; Ccap; 2900006B19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12879

Summary

Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within animal organ development and regulation of transcription, DNA-templated. Located in several cellular components, including cytoskeleton; cytosol; and membrane raft. Is expressed in brain; heart; liver; lung; and metanephros. Used to study autosomal recessive polycystic kidney disease. Orthologous to human CYS1 (cystin 1). [provided by Alliance of Genome Resources, Apr 2022]

Cys1 Products (3)

mRNA Protein Name
NM_001004455.2 NP_001004455.2 cystin-1
NM_001161807.1 NP_001155279.1 cystin-1
NM_138686.3 NP_619627.3 cystin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
24349431 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24349431 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
24349431 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within inner ear development IMP
IMP: Inferred from mutant phenotype
1952600 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
18829740 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
24349431 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24349431 MGI
Cellular Component GO Annotation Evidence References Source
located in axoneme IDA
IDA: Inferred from direct assay
11854326 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
11854326 MGI
located in cytosol IDA
IDA: Inferred from direct assay
24349431 MGI
located in membrane IDA
IDA: Inferred from direct assay
24349431 MGI
located in nucleus IDA
IDA: Inferred from direct assay
24349431 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cystin-1

  • cilia-associated protein

  • congenital polycystic kidneys

  • cystin cilia associated protein

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0090 Calcitonin (salmon) Agonist 99.96% Unkown
HY-B1811 Vasopressin 99.65% Yes
HY-P0049 Argipressin Agonist 98.71% Unkown
HY-P0004 Lysipressin Activator 99.22% Unkown
HY-A0182 Felypressin Agonist 99.74% Unkown
HY-17584A Linaclotide acetate Agonist 98.75% Unkown
HY-P0083 Ornipressin Agonist 99.87% Unkown
HY-P0049A Argipressin diacetate / Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-W539944 Argipressin acetate 99.16% Phase 4
HY-A0182A Felypressin acetate Agonist 98.90% Phase 4
HY-P5533 CRT 99.76% Phase 4
HY-P3448 Certepetide Activator 99.80% Phase 2
HY-106302 Duramycin 99.72% Phase 2

Pre-clinical Phase

Bioactive Molecules (95)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0202 Endothelin 1 (swine, human) Activator 99.12% Unkown
HY-P0256 Apamin Inhibitor 99.96% Unkown
HY-P0204A Endothelin-3, human, mouse, rabbit, rat TFA 99.57% Unkown
HY-P4860 Adropin (34-76) (human, mouse, rat) 98.23% Unkown
HY-P0202A Endothelin 1 (swine, human) TFA 99.77% Unkown
HY-P5322 Thrombospondin (TSP-1)-derived CD36 binding motif 99.58% Unkown
HY-P1408 Obtustatin 99.94% Unkown
HY-P1206 CH 275 Agonist 99.52% Unkown
HY-P1408A Obtustatin triacetate Inhibitor 99.97% Unkown
HY-P3226 JB-1 99.63% Unkown
HY-P3561A Agouti-related Protein (AGRP) (83-132) Amide (human) TFA Inhibitor 96.96% Unkown
HY-P2526 LyP-1 99.68% Unkown
HY-P11474 FZ1 peptide 99.92% Unkown
HY-P0204 Endothelin-3, human, mouse, rabbit, rat 97.58% Unkown
HY-P0207A Endothelin-2 (49-69), human TFA Ligand 99.21% Unkown
HY-17571F Biotin-Oxytocin 99.95% Unkown
HY-P10235 Cyclic AC253 Antagonist 99.83% Unkown
HY-P10557 DAG peptide 99.88% Unkown
HY-P4605A (Ile8)-Oxytocin acetate 99.65% Unkown
HY-P0256A Apamin TFA Inhibitor 97.49% Unkown
HY-P11354A THR-123 TFA / Unkown
HY-P4678 (Phe2,Orn8)-Oxytocin Agonist 99.55% Unkown
HY-102029 Sarafotoxin S6c Agonist 98.19% Unkown
HY-172275A DSPE-PEG2000-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8) 95.20% Unkown
HY-P10934 LXY3 Inhibitor 98.33% Unkown
HY-P2538 Big Endothelin-1 (1-38), human Agonist 99.23% Unkown
HY-P10383 SPSB2-iNOS inhibitory cyclic peptide-1 99.81% Unkown
HY-P3215 Oxytocin parallel dimer Activator 98.29% Unkown
HY-P4605 (Ile8)-Oxytocin 99.65% Unkown
HY-P0083A Ornipressin acetate Agonist 99.63% Unkown
HY-P0207 Endothelin-2 (49-69), human Ligand 99.86% Unkown
HY-P11094 Tet1-Cys peptide 99.13% Unkown
HY-P11143 IL4RPep-1 Inhibitor / Unkown
HY-P11143A IL4RPep-1 acetate 98.61% Unkown
HY-P11610 KBP-089 Agonist / Unkown
HY-P1463 Calcitonin, eel / Unkown
HY-P1463A Calcitonin, eel TFA 99.91% Unkown
HY-P1574 [Arg8]-Vasotocin / Unkown
HY-P1574A [Arg8]-Vasotocin TFA 98.41% Unkown
HY-P1789A CTTHWGFTLC, CYCLIC TFA Inhibitor 98.52% Unkown
HY-P3215A Oxytocin parallel dimer TFA Activator 98.10% Unkown
HY-P4205 Aminopeptidase N Ligand (CD13) NGR peptide Inhibitor 99.54% Unkown
HY-P4990 Pro8-Oxytocin Activator 99.68% Unkown
HY-P4990A Pro8-Oxytocin TFA Activator 99.68% Unkown
HY-P0090S Calcitonin-13C6,15N4 (salmon) TFA Agonist / Unkown
HY-172275 DSPE-PEG1000-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8) / Unkown
HY-P0038 MK-852 Antagonist / Unkown
HY-P0090A Calcitonin (salmon) acetate Agonist / Unkown
HY-P10237 Calcitonin (chicken) Modulator / Unkown
HY-P10328 Vasoactive intestinal contractor Inhibitor / Unkown
HY-P10383A SPSB2-iNOS inhibitory cyclic peptide-1 TFA / Unkown
HY-P10693 CZEN-002 Inhibitor / Unkown
HY-P10698 VH-N412 / Unkown
HY-P10826 PD-1/PD-L1 inhibitory peptide C8 Inhibitor / Unkown
HY-P10835 LAG-3 cyclic peptide inhibitor C25 Inhibitor / Unkown
HY-P10837 LAG-3 cyclic peptide inhibitor 12 Inhibitor / Unkown
HY-P10924 Roseltide rT1 Inhibitor / Unkown
HY-P11246 A13:B7-24-GG Agonist / Unkown
HY-P11264 Cyclic peptide P1-1 / Unkown
HY-P11354 THR-123 / Unkown
HY-P11408 [D-Cys6,Asn7,D-Ala11,Cys14]-Bombesin (6-14) Agonist / Unkown
HY-P11588 KBP-042 Activator / Unkown
HY-P11612 ATS-9R / Unkown
HY-P11745 CGSPGWVRC / Unkown
HY-P11762 CKGGRAKDC (Disulfide bridge: Cys1-Cys9) / Unkown
HY-P11814 cTMTP1 / Unkown
HY-P11816 DOTA-cTMTP1 / Unkown
HY-P11823 FAPα/DPP4 flurogenic substrate-1 / Unkown
HY-P11827 C11 peptide-1 Inhibitor / Unkown
HY-P1371 Pseudo RACK1 Agonist / Unkown
HY-P1372 PKC ζ pseudosubstrate Inhibitor / Unkown
HY-P1719 Recanaclotide / Unkown
HY-P1789 CTTHWGFTLC, CYCLIC Inhibitor / Unkown
HY-P2005 Malformin C / Unkown
HY-P2496 Endothelin 1 (swine, human), Alexa Fluor 488-labeled / Unkown
HY-P2539 Big Endothelin-1 (1-39), porcine Agonist / Unkown
HY-P3171 Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) / Unkown
HY-P3433 Sarafotoxin S6b Agonist / Unkown
HY-P3561 Agouti-related Protein (AGRP) (83-132) Amide (human) Antagonist / Unkown
HY-P3563 [Lys4] Sarafotoxin S6c Agonist / Unkown
HY-P3565 Sarafotoxin S6d / Unkown
HY-P3571 [Ala2] Endothelin-3, human / Unkown
HY-P4320 Cys-Arg-Gly-Asp-Phe-Pro-Ala-Ser-Ser-Cys (Disulfide bridge: Cys1-Cys10) Antagonist / Unkown
HY-P4678A (Phe2,Orn8)-Oxytocin acetate Agonist / Unkown
HY-P4994 Val9-Oxytocin Antagonist / Unkown
HY-P5010 (D-Arg8)-Inotocin Antagonist / Unkown
HY-P5017 (Val3,Pro8)-Oxytocin Agonist / Unkown
HY-P5130 Big endothelin-1 (rat 1-39) Ligand / Unkown
HY-P5140 ω-Tbo-IT1 Inhibitor / Unkown
HY-P5568 Siamycin III Inhibitor / Unkown
HY-P5738 Palicourein Inhibitor / Unkown
HY-P5907 Helianorphin-19 Activator / Unkown
HY-RS03493 CYS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P3448S Certepetide-13C6,15N2 Activator / Unkown
HY-P3448S1 Certepetide-13C2,15N Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cys1 NCBI NCBI:192668