Hras - Harvey rat sarcoma virus oncogene Gene

Also Known as ras; H-ras; Hras1; Kras2; Ha-ras; Hras-1; c-H-ras; c-rasHa; c-Ha-ras; Harvey-ras

Species: Mus musculus

Gene Type: protein coding
Gene ID: 15461

About Hras

Chromosome 7: 140,769,018-140,773,918 reverse strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 225 orthologues, 35 paralogues and is associated with 33 phenotypes. Ubiquitous expression in CNS E18 (RPKM 31.5), cortex adult (RPKM 31.3) and 28 other tissues.

Summary

Enables GTP binding activity. Involved in Ras protein signal transduction. Acts upstream of or within several processes, including defense response to protozoan; intracellular signal transduction; and positive regulation of interferon-gamma production. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in glutamatergic synapse and plasma membrane. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome; high grade glioma; and malignant astrocytoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Hras Products (7)

mRNA Protein Name
NM_001130443.2 NP_001123915.1 GTPase HRas isoform 1
NM_001412480.1 NP_001399409.1 GTPase HRas isoform 1
NM_008284.3 NP_032310.2 GTPase HRas isoform 1
NM_001412481.1 NP_001399410.1 GTPase HRas isoform 1
NM_001412478.1 NP_001399407.1 GTPase HRas isoform 1
NM_001130444.2 NP_001123916.1 GTPase HRas isoform 2
NM_001412479.1 NP_001399408.1 GTPase HRas isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
18604197 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8939998 MGI
enables protein-membrane adaptor activity IDA
IDA: Inferred from direct assay
16405865 MGI
Biological Process GO Annotation Evidence References Source
involved in Ras protein signal transduction IGI
IGI: Inferred from genetic interaction
11877426 MGI
involved in Schwann cell development IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21444916 MGI
acts upstream of or within T-helper 1 type immune response IMP
IMP: Inferred from mutant phenotype
21444916 MGI
involved in adipose tissue development IMP
IMP: Inferred from mutant phenotype
31408278 MGI
acts upstream of or within cellular senescence IDA
IDA: Inferred from direct assay
12878730 MGI
acts upstream of or within defense response to protozoan IMP
IMP: Inferred from mutant phenotype
21444916 MGI
acts upstream of or within endocytosis IDA
IDA: Inferred from direct assay
12446704 MGI
acts upstream of fibroblast proliferation IDA
IDA: Inferred from direct assay
16478791 MGI
involved in insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
7829473 MGI
acts upstream of or within intrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
16954213 MGI
acts upstream of or within intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
16954213 MGI
involved in myelination IMP
IMP: Inferred from mutant phenotype
10704452 MGI
acts upstream of or within negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
10845775 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10845775 MGI
acts upstream of neuron apoptotic process IDA
IDA: Inferred from direct assay
10845775 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
10845775 MGI
acts upstream of or within oncogene-induced cell senescence IDA
IDA: Inferred from direct assay
11551927 MGI
acts upstream of or within positive regulation of cell population proliferation IPI
IPI: Inferred from physical interaction
14712229 MGI
acts upstream of or within positive regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
16478791 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
21357543 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
21444916 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
12427827 MGI
acts upstream of or within small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
14712229 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hras Protein Structure

H_N_K_Ras_like

H_N_K_Ras_like: cd04138 (2 - 163)

  • 0
  • 100
  • 189 a.a.
Protein Preferred Names Protein Names

GTPase HRas

  • H-Ras-1

  • H-ras 1 protein

  • Harvey rat sarcoma virus oncogene 1

  • c-Ha-ras p21 protein

  • c-Ha-ras transgene

  • p21ras

  • transforming protein P21

Hras Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Hras Q61411 Rassf5 Mus musculus Q5EBH1
Anti Tag CoIP
9488663
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0660 Eicosapentaenoic Acid Activator 98.09% Yes
HY-15136 Lonafarnib 99.85% Yes
HY-B0984 Fendiline hydrochloride 99.78% Unkown
HY-B0984A Fendiline 99.41% Unkown
HY-B0984R Fendiline hydrochloride (Standard) 99.76% Unkown
HY-W011269 Eicosapentaenoic Acid sodium Activator 95.78% Yes

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-176785S MCB-294 98.04% Phase 4
HY-148439 Daraxonrasib Inhibitor 99.96% Phase 3
HY-16111 BMS-214662 Inhibitor 99.86% Phase 1
HY-16373 CP-609754 Inhibitor 99.49% Phase 1

Pre-clinical Phase

Bioactive Molecules (43)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156498 RMC-7977 Inhibitor 99.48% Unkown
HY-100002 ML162 99.52% Unkown
HY-173632 AMG410 Inhibitor 99.75% Unkown
HY-122862 RAS inhibitor Abd-7 Inhibitor 99.57% Unkown
HY-176786 MCB-36 98.43% Unkown
HY-113849 MLS-573151 Inhibitor 99.66% Unkown
HY-123242 FTI-2153 Inhibitor 99.77% Unkown
HY-125904 4-Hydroxyretinoic acid ≥95.0% Unkown
HY-15879 LB42708 ≥99.0% Unkown
HY-181420A BBO-11818 99.77% Unkown
HY-15873A FTI 276 TFA Inhibitor 98.31% Unkown
HY-145962A MRTX-EX185 formic Inhibitor / Unkown
HY-N10336 Notoginsenoside R4 99.90% Unkown
HY-115489A GGTI-286 TFA Inhibitor / Unkown
HY-16111A BMS-214662 hydrochloride Inhibitor 98.54% Unkown
HY-115489 GGTI-286 Inhibitor / Unkown
HY-145962 MRTX-EX185 Inhibitor / Unkown
HY-117935 GGTI-286 hydrochloride Inhibitor / Unkown
HY-123242A FTI-2153 TFA Inhibitor 99.11% Unkown
HY-RS06355 Hras Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-106603 Sulofenur / Unkown
HY-116428 L-744832 / Unkown
HY-117807 A-176120 Inhibitor / Unkown
HY-120763 LB42908 Inhibitor / Unkown
HY-122685 UC-773587 Inhibitor / Unkown
HY-128762 ML256 Inhibitor / Unkown
HY-134505 Avicin G Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 / Unkown
HY-15136B (Rac)-Lonafarnib / Unkown
HY-173632A AMG410 diTFA Inhibitor / Unkown
HY-175870A (7R)-Eras-4001 Inhibitor / Unkown
HY-176349S HRAS, Arg-13C6,15N4, Lys-13C6,15N2 / Unkown
HY-181420 (S,R,S)-BBO-11818 / Unkown
HY-182411 KRAS-IN-56 Inhibitor / Unkown
HY-183931 NPA101.3 Inhibitor / Unkown
HY-B0660S1 Eicosapentaenoic acid 1,2,3,4,5-13C5 Activator / Unkown
HY-B0660S2 Eicosapentaenoic acid-d10 / Unkown
HY-RS06354 HRAS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06356 Hras Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1126467 RAS-IN-5 Inhibitor / Unkown
HY-120271 GGTI-297 Inhibitor / Unkown
HY-B0660A Eicosapentaenoic acid metformin Activator / Unkown
HY-N10379 19-epi-Scholaricine 99.14% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hras NCBI NCBI:3265