Smad2 - SMAD family member 2 Gene

Also Known as Madh2; Madr2; mMad2; Smad-2; 7120426M23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17126

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and Tau Protein binding activity. Involved in positive regulation of epithelial to mesenchymal transition and secondary palate development. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian Cancer. Orthologous to human SMAD2 (Smad Family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Smad2 Products (3)

mRNA Protein Name
NM_001252481.1 NP_001239410.1 mothers against decapentaplegic homolog 2 isoform 1
NM_001311070.1 NP_001297999.1 mothers against decapentaplegic homolog 2 isoform 2
NM_010754.5 NP_034884.2 mothers against decapentaplegic homolog 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
27336669 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IPI
IPI: Inferred from physical interaction
24964035 MGI
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
9702197 MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
11937490 MGI
enables SMAD binding IPI
IPI: Inferred from physical interaction
11160896 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
15657445 MGI
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
15282343 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
21724602 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9702197 MGI
enables tau protein binding IDA
IDA: Inferred from direct assay
24964035 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within SMAD protein signal transduction IGI
IGI: Inferred from genetic interaction
23390484 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
9529255 MGI
involved in aortic valve morphogenesis IGI
IGI: Inferred from genetic interaction
23531444 MGI
acts upstream of or within cell fate commitment IMP
IMP: Inferred from mutant phenotype
12842913 MGI
acts upstream of or within cell population proliferation IGI
IGI: Inferred from genetic interaction
19679673 MGI
acts upstream of or within developmental growth IGI
IGI: Inferred from genetic interaction
15183723 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: Inferred from genetic interaction
15183723 MGI
acts upstream of or within embryonic foregut morphogenesis IGI
IGI: Inferred from genetic interaction
15183723 MGI
acts upstream of or within embryonic pattern specification IGI
IGI: Inferred from genetic interaction
15183723 MGI
involved in endocardial cushion morphogenesis IGI
IGI: Inferred from genetic interaction
23531444 MGI
acts upstream of or within endoderm development IGI
IGI: Inferred from genetic interaction
15183723 MGI
acts upstream of or within endoderm formation IMP
IMP: Inferred from mutant phenotype
21822279 MGI
acts upstream of or within gastrulation IGI
IGI: Inferred from genetic interaction
15183723 MGI
acts upstream of or within heart development IGI
IGI: Inferred from genetic interaction
17849440 MGI
acts upstream of or within in utero embryonic development IGI
IGI: Inferred from genetic interaction
15183723 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17849440 MGI
acts upstream of or within insulin secretion IGI
IGI: Inferred from genetic interaction
17849440 MGI
acts upstream of or within intracellular signal transduction IDA
IDA: Inferred from direct assay
14749725 MGI
acts upstream of or within lung development IGI
IGI: Inferred from genetic interaction
17849440 MGI
acts upstream of or within mesoderm formation IMP
IMP: Inferred from mutant phenotype
15084457 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23152446 MGI
involved in odontoblast differentiation IMP
IMP: Inferred from mutant phenotype
33548622 MGI
acts upstream of or within organ growth IGI
IGI: Inferred from genetic interaction
17849440 MGI
acts upstream of or within pancreas development IGI
IGI: Inferred from genetic interaction
17849440 MGI
acts upstream of or within paraxial mesoderm morphogenesis IMP
IMP: Inferred from mutant phenotype
15084457 MGI
acts upstream of or within pattern specification process IGI
IGI: Inferred from genetic interaction
17849440 MGI
acts upstream of or within pericardium development IGI
IGI: Inferred from genetic interaction
15183723 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15282343 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
14691138 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
14691138 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23152446 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9702197 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17159989 MGI
acts upstream of or within post-embryonic development IGI
IGI: Inferred from genetic interaction
17849440 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
18990706 MGI
involved in pulmonary valve morphogenesis IGI
IGI: Inferred from genetic interaction
23531444 MGI
acts upstream of or within regulation of binding IDA
IDA: Inferred from direct assay
15282343 MGI
acts upstream of or within response to glucose IGI
IGI: Inferred from genetic interaction
17849440 MGI
acts upstream of or within response to transforming growth factor beta IGI
IGI: Inferred from genetic interaction
19679673 MGI
involved in secondary palate development IMP
IMP: Inferred from mutant phenotype
14691138 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
11557747 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18212064 MGI
involved in ureteric bud development IEP
IEP: Inferred from expression pattern
14656760 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14691138 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11160896 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
9702197 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 2

  • MAD homolog 2

  • Smad 2

  • mad-related protein 2

  • mothers against DPP homolog 2

Recombinant Smad2 Proteins

Cat. No. Product Name Accession Purity
HY-P73637 SMAD2 Protein, Mouse (sf9, His-GST) Q62432 (S2-S467) ≥ 90% as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99720 Luspatercept Inhibitor 98.92% Unkown
HY-P99590A Sotatercept (mIgG2a) Inhibitor 99.93% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-P5542 Vicatertide Inhibitor 99.24% Phase 3
HY-N2037A Higenamine hydrochloride 99.34% Phase 1
HY-183067 TAS1440 98.03% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99351 Andecaliximab Inhibitor 98.57% Phase 3

Pre-clinical Phase

Bioactive Molecules (60)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116084 Trimethylamine N-oxide Activator 98.0% Unkown
HY-126675A AS2863619 98.02% Unkown
HY-100830 NCB-0846 Inhibitor 99.61% Unkown
HY-N2037 Higenamine 99.31% Unkown
HY-108915 Trimethylamine N-oxide dihydrate Activator 99.86% Unkown
HY-116084S Trimethylamine N-oxide-d9 Activator 99.76% Unkown
HY-124447 BTYNB 98.0% Unkown
HY-N6985 Baccatin III 99.82% Unkown
HY-N6013 Aloin (mixture of A&B) 99.36% Unkown
HY-132187 Sphingosylphosphorylcholine 99.50% Unkown
HY-N3266 Methyl rosmarinate 99.89% Unkown
HY-100448A Butaprost 99.85% Unkown
HY-126675 AS2863619 free base 99.87% Unkown
HY-100444 SIS3 free base Inhibitor 98.02% Unkown
HY-144043 ALK5-IN-8 Inhibitor 98.21% Unkown
HY-18766 EW-7195 Inhibitor 98.84% Unkown
HY-122856 AZ12601011 Inhibitor 99.78% Unkown
HY-123900 AZ12799734 Inhibitor 98.67% Unkown
HY-N0363 (+)-Columbianetin 99.04% Unkown
HY-N4107 Phyllanthin Inhibitor 99.97% Unkown
HY-118528A TP0427736 hydrochloride Inhibitor 99.91% Unkown
HY-N0363A (+)-Columbianetin acetate 99.83% Unkown
HY-P10363 Tiger17 Activator 98.47% Unkown
HY-100830A NCB-0970 Control 98.81% Unkown
HY-161398 TGFβRII-IN-3 99.51% Unkown
HY-171878 BI-4659 Inhibitor 99.78% Unkown
HY-N0136B (-)-Taxifolin Inhibitor 98.98% Unkown
HY-P11223 CMF9 Inhibitor 98.65% Unkown
HY-RS13393 SMAD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117511 HJC0123 99.06% Unkown
HY-P10359A TAT-QFNP12 acetate Inhibitor 95.90% Unkown
HY-P4890A Relaxin H3 (human) TFA / Unkown
HY-RS17208 Smad2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-116084S1 Trimethylamine-N-oxide-13C3 Activator / Unkown
HY-10321G PD173074 (GMP) Inhibitor / Unkown
HY-107614G 1-Oleoyl lysophosphatidic acid sodium (GMP) Activator / Unkown
HY-120973 Butaprost free acid / Unkown
HY-126675G AS2863619 (GMP) / Unkown
HY-162404 (14S,15R)-14-Deoxyoxacyclododecindione Inhibitor / Unkown
HY-162405 STAT6-IN-12 Inhibitor / Unkown
HY-168607 ALK5-IN-83 Inhibitor / Unkown
HY-170578 SIRT2-IN-17 Inhibitor / Unkown
HY-172108 TGFβRI-IN-7 Inhibitor / Unkown
HY-181430 PXS 25 Inhibitor / Unkown
HY-181431 PXS 64 Inducer / Unkown
HY-183067A TAS1440 benzoate / Unkown
HY-P10359 TAT-QFNP12 Inhibitor / Unkown
HY-P11827 C11 peptide-1 Inhibitor / Unkown
HY-P4890 Relaxin H3 (human) / Unkown
HY-W108953 Myristoyl tetrapeptide-12 Activator / Unkown
HY-W722562 Trimethylamine oxide-15N 99.93% Unkown
HY-Y1269D Ammonium chloride, for molecular biology / Unkown
HY-118528 TP0427736 Inhibitor / Unkown
HY-12273G DMH-1 (GMP) Inhibitor / Unkown
HY-124595 MPT0B098 Inhibitor / Unkown
HY-N0363AR (+)-Columbianetin acetate (Standard) / Unkown
HY-N0363R (+)-Columbianetin (Standard) / Unkown
HY-N2037AS1 Higenamine-d4-1 hydrochloride / Unkown
HY-N6013R Aloin (mixture of A&B) (Standard) / Unkown
HY-RS23660 Smad2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P99720A Luspatercept (mIgG2a) Inhibitor 99.9% Unkown
HY-P992410 MEDI-579 Inhibitor / Unkown
HY-P992108 Efadirelaxin alfa Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad2 NCBI NCBI:4087