SMAD2 - SMAD family member 2 Gene

Also Known as JV18; LDS6; CHTD8; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4087

About SMAD2

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:47,808,957-47,930,872 (from NCBI)

This gene has 12 transcripts (splice variants), 141 orthologues, 7 paralogues and is associated with 93 phenotypes. Ubiquitous expression in thyroid (RPKM 6.6), testis (RPKM 4.0) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, Apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with Other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

SMAD2 Products (3)

mRNA	Protein	Name
NM_001003652.4	NP_001003652.1	mothers against decapentaplegic homolog 2 isoform 1
NM_001135937.3	NP_001129409.1	mothers against decapentaplegic homolog 2 isoform 2
NM_005901.6	NP_005892.1	mothers against decapentaplegic homolog 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to DNA binding	IDA IDA: Inferred from direct assay	9389648	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	9389648	GOA
contributes to DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	17438144	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9389648	GOA
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	9702198	GOA
enables I-SMAD binding	IPI IPI: Inferred from physical interaction	9256479	GOA
enables R-SMAD binding	IPI IPI: Inferred from physical interaction	9311995	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9389648	GOA
enables SMAD binding	IPI IPI: Inferred from physical interaction	11160896	GOA
enables co-SMAD binding	IPI IPI: Inferred from physical interaction	9111321	GOA
enables disordered domain specific binding	IPI IPI: Inferred from physical interaction	15231848	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	11779503	GOA
enables phosphatase binding	IPI IPI: Inferred from physical interaction	16751101	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9389648	GOA
enables transforming growth factor beta receptor binding	IPI IPI: Inferred from physical interaction	9311995	GOA
enables type I transforming growth factor beta receptor binding	IPI IPI: Inferred from physical interaction	8980228	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19122240	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within SMAD protein signal transduction	IDA IDA: Inferred from direct assay	16806156	GOA
involved in SMAD protein signal transduction	IDA IDA: Inferred from direct assay	9111321	GOA
involved in SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	17239842	GOA
involved in activin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15150278	GOA
involved in determination of left/right asymmetry in lateral mesoderm	IMP IMP: Inferred from mutant phenotype	17239842	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	14555988	GOA
involved in nodal signaling pathway	IMP IMP: Inferred from mutant phenotype	15150278	GOA
involved in positive regulation of BMP signaling pathway	IMP IMP: Inferred from mutant phenotype	19366699	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9311995	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	14555988	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9389648	GOA
involved in regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14555988	GOA
involved in response to cholesterol	IDA IDA: Inferred from direct assay	17878231	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	8752209	GOA
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8980228	GOA
involved in zygotic specification of dorsal/ventral axis	IMP IMP: Inferred from mutant phenotype	9436979	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SMAD protein complex	IDA IDA: Inferred from direct assay	18832382	GOA
part of activin responsive factor complex	IDA IDA: Inferred from direct assay	9389648	GOA
located in chromatin	IDA IDA: Inferred from direct assay	21828274	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9311995	GOA
part of heteromeric SMAD protein complex	IDA IDA: Inferred from direct assay	21828274	GOA
part of heteromeric SMAD protein complex	IPI IPI: Inferred from physical interaction	15350224	GOA
part of homomeric SMAD protein complex	IPI IPI: Inferred from physical interaction	11779503	GOA
located in nucleus	IDA IDA: Inferred from direct assay	8980228	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	15231848	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	17438144	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mothers against decapentaplegic homolog 2	MAD homolog 2

SMAD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SMAD2	Q15796	SMAD4	Homo sapiens	Q13485	CoIP	12167862
Intra	SMAD2	Q15796	SMAD4	Homo sapiens	Q13485	GMS	11779503
Intra	SMAD2	Q15796	SMAD4	Homo sapiens	Q13485	Y2H	15231748
Intra	SMAD2	Q15796	SMAD4	Homo sapiens	Q13485	PLA	22442258
Intra	SMAD2	Q15796	SMAD4	Homo sapiens	Q13485	Anti Bait CoIP	19135894
Intra	SMAD2	Q15796	SMAD4	Homo sapiens	Q13485	Anti Tag CoIP	18729074
Intra	SMAD2	Q15796	SMAD4	Homo sapiens	Q13485	Y2H Array	20211142
Intra	SMAD2	Q15796	SMAD4	Homo sapiens	Q13485	TAP	18729074
Intra	SMAD2	Q15796	SMAD4	Homo sapiens	Q13485	Anti Bait CoIP	21297662
Intra	SMAD2	Q15796	SMAD4	Homo sapiens	Q13485	Anti Tag CoIP	9389648
Intra	SMAD2	Q15796	SMAD4	Homo sapiens	Q13485	Anti Tag CoIP	33961781
Intra	SMAD2	Q15796	MTMR4	Homo sapiens	Q9NYA4	Anti Tag CoIP	20061380
Intra	SMAD2	Q15796	MTMR4	Homo sapiens	Q9NYA4	Anti Bait CoIP	20061380
Intra	SMAD2	Q15796	NEFM	Homo sapiens	P07197	Display Tech	20195357
Intra	SMAD2	Q15796	FOXH1	Homo sapiens	O75593	Affinity Techniques	9702198
Intra	SMAD2	Q15796	TRIM33	Homo sapiens	Q9UPN9	Anti Bait CoIP	19135894
Intra	SMAD2	Q15796	TP63	Homo sapiens	Q9H3D4	Anti Bait CoIP	19345189
Intra	SMAD2	Q15796	ZFR	Homo sapiens	Q96KR1	Display Tech	20195357
Intra	SMAD2	Q15796	ANK3	Homo sapiens	Q12955	Y2H	15231748
Intra	SMAD2	Q15796	DOCK9	Homo sapiens	Q9BZ29	Anti Tag CoIP	18729074
Intra	SMAD2	Q15796	DOCK9	Homo sapiens	Q9BZ29	TAP	18729074
Intra	SMAD2	Q15796	SKIL	Homo sapiens	P12757	Anti Tag CoIP	33961781
Intra	SMAD2	Q15796	ZFYVE9	Homo sapiens	O95405	Y2H	15231748
Intra	SMAD2	Q15796	ZFYVE9	Homo sapiens	O95405	Anti Tag CoIP	33961781
Intra	SMAD2	Q15796	ZFYVE9	Homo sapiens	O95405	Anti Bait CoIP	18511908
Intra	SMAD2	Q15796	SMAD3	Homo sapiens	P84022	Y2H	21988832
Intra	SMAD2	Q15796	SMAD3	Homo sapiens	P84022	TAP	18729074
Intra	SMAD2	Q15796	SKI	Homo sapiens	P12755	Anti Tag CoIP	33961781
Intra	SMAD2	Q15796	SKI	Homo sapiens	P12755	TAP	18729074
Intra	SMAD2	Q15796	TP53	Homo sapiens	P04637	Anti Bait CoIP	19345189
Intra	SMAD2	Q15796	OLIG1	Homo sapiens	Q8TAK6	Anti Tag CoIP	18923419
Intra	SMAD2	Q15796	SMURF2	Homo sapiens	Q9HAU4	ITC	22045334
Intra	SMAD2	Q15796	SMURF2	Homo sapiens	Q9HAU4	Peptide Array	22045334
Intra	SMAD2	Q15796	SMURF2	Homo sapiens	Q9HAU4	TAP	18729074
Intra	SMAD2	Q15796	RHOA	Homo sapiens	P61586	TAP	20195357
Intra	SMAD2	Q15796	SNW1	Homo sapiens	Q13573	TAP	18729074
Intra	SMAD2	Q15796	CHGB	Homo sapiens	P05060	Display Tech	20195357
Intra	SMAD2	Q15796	WWP2	Homo sapiens	O00308	Anti Tag CoIP	21258410
Intra	SMAD2	Q15796	WWP2	Homo sapiens	O00308	TAP	18729074
Intra	SMAD2	Q15796	CHUK	Homo sapiens	O15111	Pull Down	18268325
Intra	SMAD2	Q15796	CHUK	Homo sapiens	O15111	Anti Tag CoIP	18268325
Intra	SMAD2	Q15796	JUN	Homo sapiens	P05412	Display Tech	20195357
Intra	SMAD2	Q15796	PPM1A	Homo sapiens	P35813	Pull Down	16751101
Intra	SMAD2	Q15796	PPM1A	Homo sapiens	P35813	Anti Tag CoIP	16751101
Intra	SMAD2	Q15796	RANBP3	Homo sapiens	Q9H6Z4	Pull Down	21960005
Cross	SMAD2	Q15796	foxh1	Crosspus laevis	P70056	Anti Tag CoIP	9389648

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SMAD2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71536	SMAD2 Protein, Human (His-SUMO)	Q15796-1 (S2-S467)	≥ 95%, as determined by reducing SDS-PAGE.

SMAD2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80324	Smad2 Antibody (YA076)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
HY-P80853	Phospho-Smad2 (Ser250) Antibody (YA152)	WB	Human, Mouse, Rat, Hamster
HY-P80853A	Phospho-Smad2 (Ser250) Antibody (YA152)(PBS only)	WB	Human, Mouse, Rat, Hamster
HY-P80893	Smad2/3 Antibody	WB, ICC/IF, FC, IP, ChIP	Human, Mouse, Rat
HY-P83772	Phospho-SMad2 (S465+467)Antibody (YA3568)	WB, ICC/IF, IHC-P	Human, Mouse
HY-P86139	Phospho-Smad2/3(Thr8) Antibody (YA5831)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86500	Phospho-Smad2(Ser250) Antibody (YA6192)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Congenital Heart Defects, Multiple Types, 8, With Or Without Heterotaxy	CHTD8 Heart Defects, Congenital, Multiple Types, 8, With/Without Heterotaxy
Loeys-Dietz Syndrome 6	LDS6 Loeys-Dietz Syndrome, Type 6
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Loeys-Dietz Syndrome	Loeys-Dietz Aortic Aneurysm Syndrome Lds Aortic Aneurysm Syndrome Due To Tgf-Beta Receptors Anomalies Furlong Syndrome
Left-Sided Gallbladder
Osteopoikilosis	Osteopathia Condensans Disseminata Spotted Bones Dermatofibrosis Lenticularis Disseminata
Buschke-Ollendorff Syndrome	BOS Dermatoosteopoikilosis Dermatofibrosis Lenticularis Disseminata With Osteopoikilosis Osteopathia Condensans Disseminata Dermatofibrosis Lenticularis Disseminata Disseminated Dermatofibrosis With Osteopoikilosis Dermatofibrosis, Disseminated, With Osteopoikilosis Osteopoikilosis With Or Without Melorheostosis Dermatofibrosis, Disseminated With Osteopoikilosis Dermatofibrosis Disseminata Lenticularis Isolated Osteopoikilosis Osteopoikilosis, Isolated
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Melorheostosis	Candle Wax Disease Flowing Hyperostosis Hyperostosis, Monomelic Leri Syndrome Leri'S Disease Melorheostoses Melorheostosis Of Leri Melorheostosis, Isolated Periostitis Monomelic Rheostosis
Complete Atrioventricular Canal	Cavc Common Atrioventricular Canal Complete Atrioventricular Septal Defect Complete Atrioventricular Canal Defect Complete Avsd Complete Atrioventricular Septal Defect With Atrial And Ventricular Components
Hypertrophic Scars	Scars Hypertrophic Hypertrophic Scarring
Obstructive Nephropathy	Con Congenital Obstructive Nephropathy Nephropathy Obstructive
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Clear Cell Adenocarcinoma	Mesonephroma Water-Clear Cell Adenocarcinoma Adenocarcinoma, Clear Cell Malignant Mesonephroma Mesonephroid Clear Cell Carcinoma Mesonephroma, Malignant Water-Clear Cell Carcinoma Wolffian Duct Neoplasm Adenocarcinoma Clear Cell Mesonephric Tumor
Dextrocardia	Heart Predominantly In Right Hemithorax Heart In Right Chest Right-Sided Heart Congenital Dextrocardia Of Heart Transposition Of Heart
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Pancreatic Adenocarcinoma	Adenocarcinoma Of The Pancreas Adenocarcinoma Of Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Renal Fibrosis
Oral Submucous Fibrosis	Oral Submucosal Fibrosis, Including Of Tongue Osmf Oral Cavity Submucous Fibrosis Oral Submucosal Fibrosis Submucosal Fibrosis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Double Outlet Right Ventricle	Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect Taussig-Bing Syndrome Dextrotransposition Of Aorta Taussig-Bing Syndrome Or Defect Dorv Dorv With Subpulmonary Vsd Dorv-Tga Double Outlet Right Ventricle With Transposition Of The Great Arteries Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type Taussig-Bing Heart Taussig-Bing Malformation Taussig-Bing Complex Taussig-Bing Defect Taussig-Bing Double Outlet Right Ventricle With Remote Ventricular Septal Defect Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect Double Outlet Right Ventricle With Non-Committed Interventricular Communication Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis
Ureteral Disease	Ureteral Diseases Ureteral Disorders Disorder Of Ureter
Peyronie'S Disease	Induratio Penis Plastica Peyronie Disease Peyronies Disease Peyronie'S Fibromatosis Penile Induration Balanitis Xerotica Obliterans
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Aortic Aneurysm	Aortic Rupture Thoracoabdominal Aortic Aneurysm, Ruptured Ruptured Aortic Aneurysm Aortic Aneurysms Aortic Aneurysm Without Mention Of Rupture Nos Ruptured Abdominal Aortic Aneurysm Aortic Aneurysm, Ruptured Ruptured Thoracic Aortic Aneurysm
Glomerulonephritis	Bright'S Disease
Systemic Scleroderma	Scleroderma Progressive Systemic Sclerosis Systemic Sclerosis Scleroderma, Systemic Scleroderma Syndrome Dermatosclerosis Familial Progressive Scleroderma Progressive Scleroderma Scleroderma Disease Scleroderma, Localized Diffuse Scleroderma Scleroderma, Familial Progressive
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Loeys-Dietz Syndrome 5	Rienhoff Syndrome LDS5 Rnhf Reinhoff Syndrome Loeys-Dietz Syndrome, Type 5
Urinary Tract Obstruction	Obstructive Uropathy Urinary Obstruction Urologic Diseases
Holoprosencephaly	Holoprosencephaly Sequence Hpe Hpe - [Holoprosencephaly]
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Uterine Corpus Endometrial Carcinoma
Loeys-Dietz Syndrome 3	LDS3 Aneurysms-Osteoarthritis Syndrome Loeys-Dietz Syndrome With Osteoarthritis Aneurysm-Osteoarthritis Syndrome Lds1c Loeys-Dietz Syndrome, Type 3 Loeys-Dietz Syndrome, Type 1c, Formerly Lds1c, Formerly Loeys-Dietz Syndrome Type 1c Loeys-Dietz Syndrome Type 3 Aneurysm - Osteoarthritis Syndrome Loeys-Dietz Syndrome, Type 1c Aos Loeys-Dietz Syndrome 1c
Loeys-Dietz Syndrome 4	LDS4 Aneurysm, Aortic And Cerebral, With Arterial Tortuosity And Skeletal Manifestations Loeys-Dietz Syndrome Type 4 Aortic And Cerebral Aneurysm With Arterial Tortuosity And Skeletal Manifestations Loeys-Dietz Syndrome, Type 4
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Vitreous Disease	Disorder Of Vitreous Body
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Rhabdomyosarcoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Juvenile Polyposis Syndrome	JPS Juvenile Intestinal Polyposis Jip Pji Juvenile Gastrointestinal Polyposis Juvenile Polyposis Polyposis, Juvenile Intestinal Polyposis, Familial, Of Entire Gastrointestinal Tract Polyposis Familial Of Entire Gastrointestinal Tract Polyposis Juvenile Intestinal Polyposis Syndrome, Juvenile
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Aortic Valve Disease 1	Aortic Valve Disease Bicuspid Aortic Valve Aortic Valve Disorder AOVD1 Bav Bicuspid Aortic Valve Disease Familial Bicuspid Aortic Valve Aortic Valve Calcification Aovd Aortic Valve, Bicuspid Aortic Valve, Calcification Of Aortic Stenosis, Calcific Familial Bav Calcific Aortic Stenosis Calcification Of Aortic Valve Abnormality Of The Aortic Valve Aortic Valve Disease, Type 1 Aortic Valve Disease 2 Bicommissural Aortic Valve
Intraocular Pressure Quantitative Trait Locus	Glaucoma IOPQTL Glaucoma, Susceptibility To Postinfectious Glaucoma Glaucoma With Ocular Inflammation Glaucoma Secondary To Eye Inflammation Traumatic Glaucoma Glaucoma With Concussion Of Globe Glaucoma Due To Ocular Trauma Glaucoma Associated With Ocular Trauma Glaucoma Secondary To Drugs
Iga Glomerulonephritis	Iga Nephropathy Glomerulonephritis, Iga Berger'S Iga Or Igg Nephropathy Focal Glomerulonephritis Primary Iga Nephropathy Segmental Glomerulonephritis Berger Disease Berger'S Disease Igan Nephritis, Iga Type Nephropathy Iga Glomerulonephritis Focal Iga Nephropathy, Susceptibility To Primary Immunoglobulin A Nephropathy
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Aortic Dissection
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Dyssegmental Dysplasia, Silverman-Handmaker Type	DDSH Silverman-Handmaker Type Dyssegmental Dysplasia Dyssegmental Dysplasia Silverman-Handmaker Type Dyssegmental Dwarfism Silverman-Handmaker Type Dyssegmental Dwarfism, Silverman-Handmaker Type Anisospondylic Camptomicromelic Dwarfism, Silverman-Handmaker Type Anisospondylic Camptomicromelic Dwarfism Silverman-Handmaker Type Dysplasia, Dyssegmental, Silverman-Handmaker Type
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Hereditary Hemorrhagic Telangiectasia	Rendu-Osler-Weber Disease Hht Osler-Weber-Rendu Disease Telangiectasia, Hereditary Hemorrhagic Osler Hemorrhagic Telangiectasia Syndrome Orw Disease Osler Weber Rendu Syndrome Osler-Rendu-Weber Disease Osler-Weber-Rendu Syndrome Rendu-Osler Disease Telangiectasia Hereditary Hemorrhagic Telangiectasia Hemorrhagic, Hereditary Hht - [Hereditary Haemorrhagic Telangiectasia] Osler Haemorrhagic Telangiectasia Syndrome
Autosomal Dominant Intellectual Developmental Disorder 19	Autosomal Dominant Non-Syndromic Intellectual Disability 19 Autosomal Dominant Mental Retardation 19 Mrd19
Cowden Syndrome 6	CWS6 Cowden Syndrome, Type 6
Orthostatic Intolerance	Mitral Valve Prolapse Neurocirculatory Asthenia Mitral Valve Prolapse Syndrome Irritable Heart Systolic Click-Murmur Syndrome Soldiers Heart Cardiovascular Malfunction Arising From Mental Factors Cardiovascular Neurosis Da Costa'S Syndrome Krishaber'S Disease Barlow'S Syndrome Floppy Mitral Valve Mitral Leaflet Syndrome Myxomatous Mitral Valve Prolapse Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orthostatic Intolerance Due To Net Deficiency Pots Due To Net Deficiency OI Intolerance, Orthostatic Mitral Valve Prolapse, Familial, X-Linked Ballooning Mitral Valve Barlow Syndrome Flail Mitral Leaflet Myxomatous Mitral Valve Mitral Valve Prolapse-Click Syndrome Prolapsing Mitral Valve Leaflet Syndrome Billowing Mitral Valve Leaflet Posterior Mitral Leaflet Deformity Ballooning Posterior Leaflet Syndrome Blue Valve Syndrome Floppy Mitral Valve Syndrome Mitral Valvular Prolapse Systolic Click Syndrome
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Orofacial Cleft	Cleft, Orofacial
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99720	Luspatercept	Inhibitor	98.92%	Unkown
HY-P99590A	Sotatercept (mIgG2a)	Inhibitor	99.93%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P5542	Vicatertide	Inhibitor	99.24%	Phase 3
HY-N2037A	Higenamine hydrochloride		99.34%	Phase 1
HY-183067	TAS1440		98.03%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99351	Andecaliximab	Inhibitor	98.57%	Phase 3

Pre-clinical Phase

Bioactive Molecules (60)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116084	Trimethylamine N-oxide	Activator	98.0%	Unkown
HY-126675A	AS2863619		98.02%	Unkown
HY-100830	NCB-0846	Inhibitor	99.61%	Unkown
HY-N2037	Higenamine		99.31%	Unkown
HY-108915	Trimethylamine N-oxide dihydrate	Activator	99.86%	Unkown
HY-116084S	Trimethylamine N-oxide-d9	Activator	99.76%	Unkown
HY-124447	BTYNB		98.0%	Unkown
HY-N6985	Baccatin III		99.82%	Unkown
HY-N6013	Aloin (mixture of A&B)		99.36%	Unkown
HY-132187	Sphingosylphosphorylcholine		99.50%	Unkown
HY-N3266	Methyl rosmarinate		99.89%	Unkown
HY-100448A	Butaprost		99.85%	Unkown
HY-126675	AS2863619 free base		99.87%	Unkown
HY-100444	SIS3 free base	Inhibitor	98.02%	Unkown
HY-144043	ALK5-IN-8	Inhibitor	98.21%	Unkown
HY-18766	EW-7195	Inhibitor	98.84%	Unkown
HY-122856	AZ12601011	Inhibitor	99.78%	Unkown
HY-123900	AZ12799734	Inhibitor	98.67%	Unkown
HY-N0363	(+)-Columbianetin		99.04%	Unkown
HY-N4107	Phyllanthin	Inhibitor	99.97%	Unkown
HY-118528A	TP0427736 hydrochloride	Inhibitor	99.91%	Unkown
HY-N0363A	(+)-Columbianetin acetate		99.83%	Unkown
HY-P10363	Tiger17	Activator	98.47%	Unkown
HY-100830A	NCB-0970	Control	98.81%	Unkown
HY-161398	TGFβRII-IN-3		99.51%	Unkown
HY-171878	BI-4659	Inhibitor	99.78%	Unkown
HY-N0136B	(-)-Taxifolin	Inhibitor	98.98%	Unkown
HY-P11223	CMF9	Inhibitor	98.65%	Unkown
HY-RS13393	SMAD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-117511	HJC0123		99.06%	Unkown
HY-P10359A	TAT-QFNP12 acetate	Inhibitor	95.90%	Unkown
HY-P4890A	Relaxin H3 (human) TFA		/	Unkown
HY-RS17208	Smad2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-116084S1	Trimethylamine-N-oxide-13C3	Activator	/	Unkown
HY-10321G	PD173074 (GMP)	Inhibitor	/	Unkown
HY-107614G	1-Oleoyl lysophosphatidic acid sodium (GMP)	Activator	/	Unkown
HY-120973	Butaprost free acid		/	Unkown
HY-126675G	AS2863619 (GMP)		/	Unkown
HY-162404	(14S,15R)-14-Deoxyoxacyclododecindione	Inhibitor	/	Unkown
HY-162405	STAT6-IN-12	Inhibitor	/	Unkown
HY-168607	ALK5-IN-83	Inhibitor	/	Unkown
HY-170578	SIRT2-IN-17	Inhibitor	/	Unkown
HY-172108	TGFβRI-IN-7	Inhibitor	/	Unkown
HY-181430	PXS 25	Inhibitor	/	Unkown
HY-181431	PXS 64	Inducer	/	Unkown
HY-183067A	TAS1440 benzoate		/	Unkown
HY-P10359	TAT-QFNP12	Inhibitor	/	Unkown
HY-P11827	C11 peptide-1	Inhibitor	/	Unkown
HY-P4890	Relaxin H3 (human)		/	Unkown
HY-W108953	Myristoyl tetrapeptide-12	Activator	/	Unkown
HY-W722562	Trimethylamine oxide-15N		99.93%	Unkown
HY-Y1269D	Ammonium chloride, for molecular biology		/	Unkown
HY-118528	TP0427736	Inhibitor	/	Unkown
HY-12273G	DMH-1 (GMP)	Inhibitor	/	Unkown
HY-124595	MPT0B098	Inhibitor	/	Unkown
HY-N0363AR	(+)-Columbianetin acetate (Standard)		/	Unkown
HY-N0363R	(+)-Columbianetin (Standard)		/	Unkown
HY-N2037AS1	Higenamine-d4-1 hydrochloride		/	Unkown
HY-N6013R	Aloin (mixture of A&B) (Standard)		/	Unkown
HY-RS23660	Smad2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99720A	Luspatercept (mIgG2a)	Inhibitor	99.9%	Unkown
HY-P992410	MEDI-579	Inhibitor	/	Unkown
HY-P992108	Efadirelaxin alfa	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SMAD2	MGD	MGI:108051
Macaca mulatta	SMAD2	VGNC	VGNC:77810
Felis catus	SMAD2	VGNC	VGNC:68130
Rattus norvegicus	SMAD2	RGD	RGD:3031
Bos taurus	SMAD2	VGNC	VGNC:34975
Canis familiaris	SMAD2	VGNC	VGNC:46519
Others	SMAD2	NCBI