Tnks - tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Gene

Also Known as ARTD5; TANK1; mTNKS1; 4930554K12Rik; D130072O21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21951

About Tnks

Chromosome 8: 35,293,614-35,432,844 reverse strand.GRCm39:CM001001.3

This gene has 6 transcripts (splice variants), 279 orthologues, 2 paralogues and is associated with 58 phenotypes. Ubiquitous expression in testis adult (RPKM 23.3), whole brain E14.5 (RPKM 14.7) and 28 other tissues.

Summary

Predicted to enable histone binding activity; pentosyltransferase activity; and zinc ion binding activity. Predicted to be involved in several processes, including negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric; protein ADP-ribosylation; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within peptidyl-serine phosphorylation and peptidyl-threonine phosphorylation. Located in cytosol. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human TNKS (tankyrase). [provided by Alliance of Genome Resources, Apr 2022]

Tnks Products (1)

mRNA Protein Name
NM_175091.3 NP_780300.2 poly [ADP-ribose] polymerase tankyrase-1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
23791195 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tnks Protein Structure

PTZ00322

PTZ00322: cl31426 (169 - 261)

ANK

ANK: sd00045 (210 - 238)

PHA02876

PHA02876: cl31517 (223 - 608)

ANK

ANK: sd00045 (240 - 271)

ANK

ANK: sd00045 (273 - 304)

ANK

ANK: sd00045 (363 - 391)

ANK

ANK: sd00045 (393 - 424)

ANK

ANK: sd00045 (426 - 457)

ANK

ANK: sd00045 (515 - 547)

ANK

ANK: sd00045 (549 - 580)

ANK

ANK: sd00045 (582 - 611)

PHA03095

PHA03095: cl33707 (644 - 968)

ANK

ANK: sd00045 (678 - 706)

ANK

ANK: sd00045 (708 - 739)

ANK

ANK: sd00045 (741 - 772)

ANK

ANK: sd00045 (828 - 859)

ANK

ANK: sd00045 (861 - 892)

ANK

ANK: sd00045 (894 - 925)

SAM_tankyrase1,2

SAM_tankyrase1,2: cd09524 (1016 - 1081)

tankyrase_like

tankyrase_like: cd01438 (1083 - 1305)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1320 a.a.
Protein Preferred Names Protein Names

poly [ADP-ribose] polymerase tankyrase-1

  • ADP-ribosyltransferase diphtheria toxin-like 5

  • TRF1-interacting ankyrin-related ADP-ribose polymerase 1

  • protein poly-ADP-ribosyltransferase tankyrase-1

  • tankyrase I

  • tankyrase-1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108845 Tenecteplase Inhibitor 95.00% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-12418 Stenoparib Inhibitor 98.0% Phase 2
HY-147245 Basroparib Inhibitor 98.91% Phase 1

Pre-clinical Phase

Bioactive Molecules (68)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15147 XAV-939 Inhibitor 99.91% Unkown
HY-16910 WIKI4 Inhibitor 99.93% Unkown
HY-14443 XMD8-92 Inhibitor 99.48% Unkown
HY-13990 NVP-TNKS656 99.66% Unkown
HY-12438 G007-LK Inhibitor 99.24% Unkown
HY-13968 JW 55 Inhibitor 99.83% Unkown
HY-145267 OM-153 Inhibitor 99.30% Unkown
HY-123851 MSC2504877 Inhibitor 99.25% Unkown
HY-12975 AZ6102 Inhibitor 99.53% Unkown
HY-147316 TP-5801 Inhibitor 98.55% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-15800A CZC-25146 Inhibitor 99.10% Unkown
HY-19351 MN-64 Inhibitor 99.61% Unkown
HY-15811 XMD8-87 Inhibitor 99.57% Unkown
HY-101243 XMD16-5 Inhibitor 98.20% Unkown
HY-148061 DB1113 99.86% Unkown
HY-U00422 K-756 Inhibitor 99.25% Unkown
HY-148063 DB0614 96.07% Unkown
HY-153996 CT1113 99.61% Unkown
HY-126248 Tankyrase-IN-2 99.06% Unkown
HY-147316A TP-5801 TFA Inhibitor 99.55% Unkown
HY-147886 PARP1-IN-11 Inhibitor 99.42% Unkown
HY-121719 TIQ-A Inhibitor 99.85% Unkown
HY-156332 TNKS-2-IN-2 Inhibitor 99.47% Unkown
HY-164478 G-631 Inhibitor 99.88% Unkown
HY-12577 TNKS1/2-IN-1 Inhibitor 99.24% Unkown
HY-143338 ART-IN-1 Inhibitor 98.91% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 98.66% Unkown
HY-173349 TDI-012804 Inhibitor / Unkown
HY-23338 TNKS-2-IN-1 Inhibitor 95.03% Unkown
HY-100847 AZ0108 Inhibitor / Unkown
HY-108516 TC-E 5001 Inhibitor / Unkown
HY-114943 TNKS-IN-1 Inhibitor 99.55% Unkown
HY-117700 TNKS-IN-2 Inhibitor / Unkown
HY-12601 TNKS 22 Inhibitor / Unkown
HY-12602 TNKS-IN-4 Inhibitor / Unkown
HY-13990G NVP-TNKS656 (GMP) / Unkown
HY-145111 TNK2-IN-1 Inhibitor / Unkown
HY-152197 Tankyrase-IN-3 Inhibitor / Unkown
HY-152198 Tankyrase-IN-4 Inhibitor / Unkown
HY-153259 TNKS1/2-IN-2 Inhibitor / Unkown
HY-155246 PARP1-IN-15 / Unkown
HY-167762 TNKS-2-IN-4 Inhibitor / Unkown
HY-172747 TNKS-2-IN-3 Inhibitor / Unkown
HY-180926 PARP10-IN-4 Inhibitor / Unkown
HY-181752 FGFR3-IN-12 / Unkown
HY-E70868 TNK1 Recombinant Human Active Protein Kinase / Unkown
HY-RS14837 TNK1 Human Pre-designed siRNA Set A / Unkown
HY-RS14838 TNK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14839 TNKS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14840 Tnks Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14841 Tnks Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14842 TNKS1BP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14843 TNKS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14844 Tnks2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14845 TNKS2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W294889 OUL245 Inhibitor / Unkown
HY-10893 TNK-651 Inhibitor / Unkown
HY-118731 TNK-6123 Activator / Unkown
HY-153332 Tankyrase-IN-5 Inhibitor / Unkown
HY-15800 CZC-25146 hydrochloride Inhibitor / Unkown
HY-168925 EXQ-2d Inhibitor / Unkown
HY-173480 TNKS-IN-3 Inhibitor / Unkown
HY-180867 TNKS modulator-1 / Unkown
HY-RS16928 Tnk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18502 Tnk1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS23371 Tnk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24984 Tnk1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tnks NCBI NCBI:8658